SF1 and TNPO2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SF1	TNPO2
Description		splicing factor 1	transportin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome U2AF Complex	Nucleus Cytoplasm
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Primary Metabolic Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Negative Regulation Of Muscle Cell Differentiation
Pathways		mRNA Splicing - Major Pathway
Drugs		Artenimol
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Urate levels ( 21768215)	Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)
Interacting Genes		90 interacting genes: ALG13 APBB1 APOBEC3C ATXN1 BAG4 BCAS2 BCL2 BUD31 CDC42 CEBPA CEP55 CPSF7 CTBP1 CTTN DCN DDX17 DMRTB1 DUX4L9 EWSR1 EXOSC1 EXOSC8 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IDH3A IL7R ILF3 ITCH KHDRBS2 KPNA1 KRT31 KRTAP26-1 LINC00632 MIR106B MIR155 MIR19B2 MIR34A MIRLET7G MKRN3 NCK2 NEIL3 NFKB1 OGT OSTF1 PDAP1 PLSCR1 PRKG1 PRPF39 PRPF40A PRRC2B PSMA3 PUF60 PUS7 RBFOX2 RBM10 RBM17 RBM4 RBM7 RBMX RBPMS RPA2 RSPH1 SEC23A SF3B1 SF3B4 SFPQ SNRPA TAF15 TCERG1 TFIP11 TNPO2 TRIM23 TRIM69 TTN TXNL4B U2AF2 UBL5 USO1 WBP4 WDR77 WDR83 WWP2 YTHDF1 YTHDF3 ZNF461	54 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CEBPA CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RBM45 REDIC1 RIPK4 RNF10 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 ZBTB32 ZC2HC1C
Entrez ID		7536	30000
HPRD ID		03306	04301
Ensembl ID		ENSG00000168066	ENSG00000105576
Uniprot IDs		A0A7P0T9U7 A0A9L9PXE4 B4DX42 H7C561 Q15637	O14787 Q05D48
PDB IDs		1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX 7VH9 7VPX 8PXX
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process RNA Binding RNA Metabolic Process Nucleic Acid Binding Regulation Of RNA Splicing Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression MRNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Speck Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Identical Protein Binding Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA 3'-UTR Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Splicing	Identical Protein Binding Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Binding Calcium/calmodulin-dependent Protein Kinase Activity Protein Homodimerization Activity
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