SF1 and YTHDF3

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SF1	YTHDF3
Description		splicing factor 1	YTH N6-methyladenosine RNA binding protein F3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome U2AF Complex	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	RNA Binding MRNA Binding Protein Binding Ribosome Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Primary Metabolic Process	Stress Granule Assembly Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Translational Initiation Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Organelle Assembly Regulation Of Trophoblast Cell Migration
Pathways		mRNA Splicing - Major Pathway
Drugs		Artenimol
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Urate levels ( 21768215)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Chronotype ( 30696823) HDL cholesterol levels ( 32203549) Myocardial infarction ( 26708285) Schizophrenia ( 33169155) Smoking behaviour (cigarettes smoked per day) ( 30679032) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549)
Interacting Genes		90 interacting genes: ALG13 APBB1 APOBEC3C ATXN1 BAG4 BCAS2 BCL2 BUD31 CDC42 CEBPA CEP55 CPSF7 CTBP1 CTTN DCN DDX17 DMRTB1 DUX4L9 EWSR1 EXOSC1 EXOSC8 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IDH3A IL7R ILF3 ITCH KHDRBS2 KPNA1 KRT31 KRTAP26-1 LINC00632 MIR106B MIR155 MIR19B2 MIR34A MIRLET7G MKRN3 NCK2 NEIL3 NFKB1 OGT OSTF1 PDAP1 PLSCR1 PRKG1 PRPF39 PRPF40A PRRC2B PSMA3 PUF60 PUS7 RBFOX2 RBM10 RBM17 RBM4 RBM7 RBMX RBPMS RPA2 RSPH1 SEC23A SF3B1 SF3B4 SFPQ SNRPA TAF15 TCERG1 TFIP11 TNPO2 TRIM23 TRIM69 TTN TXNL4B U2AF2 UBL5 USO1 WBP4 WDR77 WDR83 WWP2 YTHDF1 YTHDF3 ZNF461	17 interacting genes: ALG13 ANKHD1 CPSF7 CTTN DMRTB1 EXOSC5 FAF1 LARP4 NMD3 PRRC2B QKI RBFOX2 RBM22 RPS21 SF1 SNRPA ZDHHC17
Entrez ID		7536	253943
HPRD ID		03306	08106
Ensembl ID		ENSG00000168066	ENSG00000185728
Uniprot IDs		A0A7P0T9U7 A0A9L9PXE4 B4DX42 H7C561 Q15637	A0A024R7W5 A0A087WY31 B4DPX9 Q7Z739 Q8NA80
PDB IDs		1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX 7VH9 7VPX 8PXX	6ZOT 8BS5 8BS6
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process RNA Binding RNA Metabolic Process Nucleic Acid Binding Regulation Of RNA Splicing Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression MRNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Speck Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Identical Protein Binding Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA 3'-UTR Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Splicing	RNA Binding Nucleic Acid Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome MRNA Binding Cytosolic Small Ribosomal Subunit Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nucleic Acid Metabolic Process Spliceosomal Complex Gamma-glutamyl-peptidase Activity Regulation Of RNA Splicing Internal N(7)-methylguanine-containing RNA Reader Activity Perforant Pathway To Dendrate Granule Cell Synapse Methionine Adenosyltransferase Regulator Activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Macromolecule Metabolic Process
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