XPNPEP1 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XPNPEP1	POLA2
Description		X-prolyl aminopeptidase 1	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol Ciliary Basal Body
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Manganese Ion Binding Protein Homodimerization Activity Metal Ion Binding Metalloaminopeptidase Activity	DNA Binding Protein Binding
	Biological Process	Proteolysis Bradykinin Catabolic Process Negative Regulation Of Programmed Cell Death CARD8 Inflammasome Complex Assembly	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation Protein Import Into Nucleus
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs			Dacarbazine
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Biliary atresia ( 20460270) Bipolar disorder ( 28072414 31043756) Refractive error ( 32231278)	Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		12 interacting genes: DISC1 GORASP2 GSK3B HBG2 MAPK9 NUDT3 POLA2 RHOH RINT1 SUMO2 UBC UBE2D3	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		7511	23649
HPRD ID		03899	10160
Ensembl ID		ENSG00000108039	ENSG00000014138
Uniprot IDs		Q5T6H7 Q9NQW7	A0A9L9PY44 H0YDR7 Q14181
PDB IDs		3CTZ	2KEB 4E2I 4Y97 5EXR 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Cell Adhesion Presynapse Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Glutamatergic Synapse Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Cytosol Positive Regulation Of Cell-matrix Adhesion Superior Temporal Gyrus Development Ubiquitin Protein Ligase Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Protein Localization To Tricellular Tight Junction 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol Phosphate Catabolic Process Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Establishment Of Protein Localization TOR Signaling Regulation Of Axon Extension JUN Kinase Activity Diphosphoinositol Polyphosphate Metabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone	DNA Replication, Synthesis Of Primer Regulation Of Phosphorus Metabolic Process Nucleic Acid Metabolic Process Collateral Sprouting RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Macromolecule Metabolic Process Alpha DNA Polymerase:primase Complex Regulation Of Glycolytic Process
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