TP63 and UBASH3A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TP63	UBASH3A
Description		tumor protein p63	ubiquitin associated and SH3 domain containing A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Dendrite Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding WW Domain Binding MDM2/MDM4 Family Protein Binding Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Establishment Of Planar Polarity Morphogenesis Of A Polarized Epithelium Hair Follicle Development Epithelial Cell Development Chromatin Remodeling Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Notch Signaling Pathway Spermatogenesis Pattern Specification Process Ectoderm And Mesoderm Interaction Positive Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Epidermis Development Animal Organ Morphogenesis Epidermal Cell Differentiation Proximal/distal Pattern Formation Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Embryonic Limb Morphogenesis Prostate Gland Development Epithelial Cell Differentiation Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Skin Morphogenesis Keratinocyte Proliferation Positive Regulation Of Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Female Genitalia Morphogenesis Stem Cell Differentiation Protein Tetramerization Neuron Apoptotic Process Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Stem Cell Proliferation Cellular Senescence Skin Epidermis Development Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Somatic Stem Cell Population Maintenance Cranial Skeletal System Development Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Activation of PUMA and translocation to mitochondria Pyroptosis TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases		Split-hand/foot malformation (SHFM) Limb-mammary syndrome Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome) ADULT syndrome Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 24163127 20972438) Brain imaging ( 20100581) Chlamydia trachomatis PorB antibody levels ( 33204752) Circulating leptin levels in high cardiovascular risk ( 31766143) Cutaneous squamous cell carcinoma ( 32041948) EGFR mutation-positive lung adenocarcinoma ( 27501781) Lung adenocarcinoma ( 20871597 28604730 22797724) Lung cancer ( 24880342 23143601 28604730 21725308) Lung cancer in never smokers ( 31009812) Metabolite levels ( 23823483) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 26098869 29422604) Postoperative stroke after cardiac surgery ( 30678657) Psoriasis ( 25903422) Psoriasis vulgaris ( 26626624) Serum CC16 levels ( 32839289) Squamous cell carcinoma ( 26829030) Systemic lupus erythematosus ( 28714469) Urinary bladder cancer ( 20348956 18794855)	Addison's disease ( 33574239) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 18840781 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 20410501)
Interacting Genes		43 interacting genes: BAG6 BTRC CCNC CDC20 CDKN2A COPS6 CSNK2A1 CSNK2A2 CSNK2B DAXX EMX1 EP300 GCGR GRB2 HIPK2 HNRNPAB HP HPX ITIH4 KAT2B MCRS1 MDM4 NEDD4 NIPSNAP3A ORM1 PELI1 PELI2 PIN1 PINX1 PML PPP1R13B PPP2R5A RACK1 RCHY1 SCAF4 SLC35A3 STUB1 TP53 TP73 UBASH3A UBE2I WT1 YAP1	105 interacting genes: ARRDC1 ARRDC3 ATF6 BCAR3 CBLB CBS CCDC33 CD3E COPS9 CUEDC1 CXXC5 DAZAP2 DDIT4L DISC1 DLG1 DLGAP4 DNM2 DTX3 EHMT2 FADS6 FAM83A FGFR1OP2 GFAP GOLGA6L9 HSP90AA1 HSP90B1 HSPD1 IKBKG ISY1-RAB43 KCNE1 KCTD1 KIAA0408 KPRP KRT14 KRT31 KRT32 KRT35 KRT39 KRT40 LCN2 LNX1 LZTS1 LZTS2 MAP3K7 MKRN1 MTIF2 N4BP3 NEUROD2 NSMF PDE7A PFDN2 PLEKHB2 PMEPA1 PNMA5 PRDM6 PRKN PSMC1 PSMC4 REL RNF216 RNF41 SF3B4 SH3RF1 SHISA6 SLA2 SLC4A3 SNRNP48 SOS1 SOS2 SPMIP6 SPRY1 SPRY2 SPRYD7 STX11 TAOK1 TAX1BP1 TEKT1 TEKT4 TIMM44 TMCO2 TMEM239 TP53BP2 TP63 TRIM27 TRIM37 TRIM5 TRIM50 TRIM8 TUBB8 UBB UBC UBE2L3 VCP VPS37B VPS72 WAS WASL WBP11 YPEL3 ZBTB42 ZC2HC1C ZIC3 ZNF219 ZNF474 ZRANB1
Entrez ID		8626	53347
HPRD ID		04469	06904
Ensembl ID		ENSG00000073282	ENSG00000160185
Uniprot IDs		A0A0S2Z4N5 A0A0S2Z4N6 A0A141PNN3 A0A141PNN4 B7Z8X6 C9D7D0 Q9H3D4	P57075
PDB IDs		1RG6 2NB1 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z 6FGN 6RU6 6RU7 6RU8 7Z71 7Z72 7Z73 7Z7E 8P9C 8P9D 8P9E 9GFO	2CRN 5WDI
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Regulation Of Primary Metabolic Process Cellular Response To Stress DNA Damage Response Regulation Of Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Modification Process Negative Regulation Of Metabolic Process P53 Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteolysis Nucleus Regulation Of Cellular Response To Stress Apoptotic Signaling Pathway Protein Stabilization Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Protein Kinase CK2 Complex Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Stress Protein Metabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Negative Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Inclusion Body Assembly Post-translational Protein Modification Ubiquitin Protein Ligase Activity Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Identical Protein Binding Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Catabolic Process Sperm Plasma Membrane WW Domain Binding Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Keratin Filament Canonical NF-kappaB Signal Transduction Negative Regulation Of Membrane Tubulation Cytosol Cytoskeleton Organization Tissue Morphogenesis Positive Regulation Of Protein Catabolic Process Organelle Organization Modification-dependent Protein Catabolic Process Intermediate Filament Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Regulation Of Intracellular Signal Transduction SH3 Domain Binding P53 Binding Protein Localization To Mitochondrion Linear Polyubiquitin Binding Regulation Of Protein Catabolic Process Protein Polymerization Regulation Of Autophagy Regulation Of Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity
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