TP63 and GCGR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TP63	GCGR
Gene Name		tumor protein p63	glucagon receptor
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Rough Endoplasmic Reticulum Cytosol Dendrite	Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding WW Domain Binding	Glucagon Receptor Activity Guanyl-nucleotide Exchange Factor Activity Peptide Hormone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Replicative Cell Aging Skeletal System Development Establishment Of Planar Polarity Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Development Chromatin Remodeling Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Notch Signaling Pathway Spermatogenesis Ectoderm And Mesoderm Interaction Proximal/distal Pattern Formation Response To X-ray Multicellular Organismal Aging Response To Gamma Radiation Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Embryonic Limb Morphogenesis Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Mitotic G1 DNA Damage Checkpoint Cellular Response To UV Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Neuron Apoptotic Process Keratinocyte Proliferation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Smooth Muscle Tissue Development Female Genitalia Morphogenesis Protein Homotetramerization Neuron Apoptotic Process Urinary Bladder Development Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development Negative Regulation Of Cellular Senescence Positive Regulation Of Apoptotic Signaling Pathway	Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Exocytosis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Nutrient Regulation Of Blood Pressure Hormone-mediated Signaling Pathway Glucose Homeostasis Response To Starvation Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Regulation Of Glycogen Metabolic Process Cellular Response To Glucagon Stimulus
Pathways			G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class B/2 (Secretin family receptors) Glucagon signaling in metabolic regulation
Drugs			Glucagon recombinant
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 20972438) Brain imaging ( 20100581) Lung adenocarcinoma ( 22797724 20871597) Lung cancer ( 21725308 23143601) Urinary bladder cancer ( 20348956 18794855)
Protein-Protein Interactions		32 interactors: BAG6 BTRC CCNC CDKN2A COPS6 DAXX EMX1 EP300 GCGR GNB2L1 GRB2 HIPK2 HNRNPAB HP HPX ITIH4 KAT2B MDM4 NIPSNAP3A ORM1 PINX1 PML PPP1R13B PPP2R5A RCHY1 SCAF4 SLC35A3 TP53 TP73 UBE2I WT1 YAP1	4 interactors: GCG GNAS TGM2 TP63
Entrez ID		8626	2642
HPRD ID		04469	00678
Ensembl ID		ENSG00000073282	ENSG00000215644
Uniprot IDs		C9D7D0 Q9H3D4	P47871
PDB IDs		1RG6 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z	3CZF 4ERS 4L6R
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Signal Transduction By P53 Class Mediator Viral Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Signal Transduction In Response To DNA Damage Cell Cycle Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Gene Expression Cell Cycle Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Modification Process Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Regulation Of Protein Stability Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Cell Death Death Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Mitotic Cell Cycle Process Protein Stabilization Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Gamma Radiation Negative Regulation Of Growth Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction Resulting In Transcription	Positive Regulation Of Signal Transduction Cellular Response To Glucagon Stimulus Multicellular Organismal Water Homeostasis Response To Glucagon Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Hair Follicle Development Hair Cycle Process Positive Regulation Of Ossification Regulation Of CAMP Metabolic Process Hair Cycle Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Epidermal Cell Division Post-embryonic Body Morphogenesis Ectoderm And Mesoderm Interaction Regulation Of Osteoblast Differentiation Chemical Homeostasis Energy Reserve Metabolic Process Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Gland Morphogenesis Embryonic Limb Morphogenesis Organ Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Anatomical Structure Formation Involved In Morphogenesis Limb Morphogenesis Epithelium Development Regulation Of Ossification Regulation Of Insulin Secretion Limb Development G-protein Coupled Receptor Signaling Pathway Regulation Of Epidermal Cell Division Regulation Of Peptide Hormone Secretion Skin Development Morphogenesis Of A Branching Epithelium Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Female Genitalia Morphogenesis Morphogenesis Of A Branching Structure Protein Homooligomerization Regulation Of Hormone Secretion Epidermis Development Homeostatic Process
Tagcloud ?		adenocarcinomas advantages ago aiding apply complexity discrepant emerge emphasize experimentally generalisations gives haematological isoform lymphomas methodologies mis np63 np73 p73 reagents sense sometimes tap63 tap73 themes translocations universally	atp6v0d2 ctsk gpnmb granuloma instillation intratracheal lilrb4 lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts tnfsf4 toxicological trem2 upregulated
Tagcloud (Difference) ?		adenocarcinomas advantages ago aiding apply complexity discrepant emerge emphasize experimentally generalisations gives haematological isoform lymphomas methodologies mis np63 np73 p73 reagents sense sometimes tap63 tap73 themes translocations universally	atp6v0d2 ctsk gpnmb granuloma instillation intratracheal lilrb4 lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts tnfsf4 toxicological trem2 upregulated
Tagcloud (Intersection) ?