TP63 and HPX

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TP63	HPX
Gene Name		tumor protein p63	hemopexin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Rough Endoplasmic Reticulum Cytosol Dendrite	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding WW Domain Binding	Protein Binding Heme Transporter Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Replicative Cell Aging Skeletal System Development Establishment Of Planar Polarity Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Development Chromatin Remodeling Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Notch Signaling Pathway Spermatogenesis Ectoderm And Mesoderm Interaction Proximal/distal Pattern Formation Response To X-ray Multicellular Organismal Aging Response To Gamma Radiation Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Embryonic Limb Morphogenesis Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Mitotic G1 DNA Damage Checkpoint Cellular Response To UV Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Neuron Apoptotic Process Keratinocyte Proliferation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Smooth Muscle Tissue Development Female Genitalia Morphogenesis Protein Homotetramerization Neuron Apoptotic Process Urinary Bladder Development Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development Negative Regulation Of Cellular Senescence Positive Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Immunoglobulin Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Heme Transport Viral Process Hemoglobin Metabolic Process Heme Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways			Scavenging of heme from plasma
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 20972438) Brain imaging ( 20100581) Lung adenocarcinoma ( 22797724 20871597) Lung cancer ( 21725308 23143601) Urinary bladder cancer ( 20348956 18794855)
Protein-Protein Interactions		32 interactors: BAG6 BTRC CCNC CDKN2A COPS6 DAXX EMX1 EP300 GCGR GNB2L1 GRB2 HIPK2 HNRNPAB HP HPX ITIH4 KAT2B MDM4 NIPSNAP3A ORM1 PINX1 PML PPP1R13B PPP2R5A RCHY1 SCAF4 SLC35A3 TP53 TP73 UBE2I WT1 YAP1	2 interactors: GLUD1 TP63
Entrez ID		8626	3263
HPRD ID		04469	00793
Ensembl ID		ENSG00000073282	ENSG00000110169
Uniprot IDs		C9D7D0 Q9H3D4	P02790 Q9BS19
PDB IDs		1RG6 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Signal Transduction By P53 Class Mediator Viral Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Signal Transduction In Response To DNA Damage Cell Cycle Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Gene Expression Cell Cycle Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Modification Process Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Regulation Of Protein Stability Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Cell Death Death Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Mitotic Cell Cycle Process Protein Stabilization Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Gamma Radiation Negative Regulation Of Growth Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction Resulting In Transcription	Ectoderm And Mesoderm Interaction Epidermal Cell Division Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Regulation Of Epidermal Cell Division Female Genitalia Morphogenesis Cloacal Septation Urinary Bladder Development Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Prostatic Bud Formation Glutamate Catabolic Process Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Glutamate Biosynthetic Process Replicative Cell Aging Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Negative Regulation Of Epidermal Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Dicarboxylic Acid Catabolic Process Negative Regulation Of Cell Aging Keratinocyte Proliferation Establishment Of Skin Barrier Establishment Of Planar Polarity Epithelial Cell Differentiation Involved In Prostate Gland Development Genitalia Morphogenesis Regulation Of Water Loss Via Skin Post-anal Tail Morphogenesis Regulation Of Fibroblast Apoptotic Process Regulation Of Keratinocyte Proliferation Female Genitalia Development Sympathetic Nervous System Development Glutamate Metabolic Process Morphogenesis Of A Polarized Epithelium Regulation Of Cellular Senescence Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Notch Signaling Pathway Regulation Of Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Smooth Muscle Tissue Development Response To X-ray Hair Follicle Morphogenesis Morphogenesis Of An Epithelial Fold Negative Regulation Of Epithelial Cell Differentiation Glutamine Metabolic Process Substantia Nigra Development Prostate Gland Epithelium Morphogenesis
Tagcloud ?		adenocarcinomas advantages ago aiding apply complexity discrepant emerge emphasize experimentally generalisations gives haematological isoform lymphomas methodologies mis np63 np73 p73 reagents sense sometimes tap63 tap73 themes translocations universally	acutely antral atresia autoradiography disconnection ewes externa follicles follicular folliculogenesis fsh gonadotropin gonadotropins granulosa greatest hpd hypophysectomy interna lh localize membrana nonspecific ovulation preantral stalk theca unless unresponsive unsuccessful
Tagcloud (Difference) ?		adenocarcinomas advantages ago aiding apply complexity discrepant emerge emphasize experimentally generalisations gives haematological isoform lymphomas methodologies mis np63 np73 p73 reagents sense sometimes tap63 tap73 themes translocations universally	acutely antral atresia autoradiography disconnection ewes externa follicles follicular folliculogenesis fsh gonadotropin gonadotropins granulosa greatest hpd hypophysectomy interna lh localize membrana nonspecific ovulation preantral stalk theca unless unresponsive unsuccessful
Tagcloud (Intersection) ?