TP63 and HNRNPAB

Number of citations of the paper that reports this interaction (PMID 12692135)
13

Data Source:
HPRD (two hybrid, in vitro)

		TP63	HNRNPAB
Gene Name		tumor protein p63	heterogeneous nuclear ribonucleoprotein A/B
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Rough Endoplasmic Reticulum Cytosol Dendrite	Nucleus Nucleoplasm Cytoplasm Ribonucleoprotein Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding WW Domain Binding	Nucleotide Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding MRNA Binding Sequence-specific DNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Replicative Cell Aging Skeletal System Development Establishment Of Planar Polarity Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Development Chromatin Remodeling Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Notch Signaling Pathway Spermatogenesis Ectoderm And Mesoderm Interaction Proximal/distal Pattern Formation Response To X-ray Multicellular Organismal Aging Response To Gamma Radiation Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Embryonic Limb Morphogenesis Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Mitotic G1 DNA Damage Checkpoint Cellular Response To UV Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Neuron Apoptotic Process Keratinocyte Proliferation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Smooth Muscle Tissue Development Female Genitalia Morphogenesis Protein Homotetramerization Neuron Apoptotic Process Urinary Bladder Development Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development Negative Regulation Of Cellular Senescence Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 20972438) Brain imaging ( 20100581) Lung adenocarcinoma ( 22797724 20871597) Lung cancer ( 21725308 23143601) Urinary bladder cancer ( 20348956 18794855)
Protein-Protein Interactions		32 interactors: BAG6 BTRC CCNC CDKN2A COPS6 DAXX EMX1 EP300 GCGR GNB2L1 GRB2 HIPK2 HNRNPAB HP HPX ITIH4 KAT2B MDM4 NIPSNAP3A ORM1 PINX1 PML PPP1R13B PPP2R5A RCHY1 SCAF4 SLC35A3 TP53 TP73 UBE2I WT1 YAP1	16 interactors: ACTB DEDD2 ELAVL2 ERG HIST3H3 HMGA1 HOXC13 HOXD4 IL7R POLR3D PTBP1 PTBP2 RBFOX2 TP63 USP19 YWHAG
Entrez ID		8626	3182
HPRD ID		04469	04067
Ensembl ID		ENSG00000073282	ENSG00000197451
Uniprot IDs		C9D7D0 Q9H3D4	Q99729
PDB IDs		1RG6 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z	3S7R
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Signal Transduction By P53 Class Mediator Viral Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Signal Transduction In Response To DNA Damage Cell Cycle Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Gene Expression Cell Cycle Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Modification Process Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Regulation Of Protein Stability Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Cell Death Death Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Mitotic Cell Cycle Process Protein Stabilization Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Gamma Radiation Negative Regulation Of Growth Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction Resulting In Transcription	Regulation Of Gene Expression RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Regulation Of Cellular Senescence Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Homeostatic Process Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Positive Regulation Of Apoptotic Signaling Pathway Transcription, DNA-templated RNA Processing RNA Biosynthetic Process Epidermal Cell Division Ectoderm And Mesoderm Interaction Negative Regulation Of Potassium Ion Export Regulation Of MRNA Splicing, Via Spliceosome Cell Aging Regulation Of Heart Rate By Hormone Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Interleukin-7-mediated Signaling Pathway Oncogene-induced Cell Senescence RNA Splicing Apoptotic Signaling Pathway Regulation Of MRNA Processing Cellular Metabolic Process Hair Follicle Development Hair Cycle Process Regulation Of Epidermal Cell Division Senescence-associated Heterochromatin Focus Assembly Regulation Of Cellular Process Hair Cycle MRNA Processing Positive Regulation Of Cellular Senescence Female Genitalia Morphogenesis Regulation Of Cell Differentiation Radial Glia Guided Migration Of Purkinje Cell Regulation Of Cellular Response To Hypoxia Regulation Of Definitive Erythrocyte Differentiation Cloacal Septation
Tagcloud ?		adenocarcinomas advantages ago aiding apply complexity discrepant emerge emphasize experimentally generalisations gives haematological isoform lymphomas methodologies mis np63 np73 p73 reagents sense sometimes tap63 tap73 themes translocations universally
Tagcloud (Difference) ?		adenocarcinomas advantages ago aiding apply complexity discrepant emerge emphasize experimentally generalisations gives haematological isoform lymphomas methodologies mis np63 np73 p73 reagents sense sometimes tap63 tap73 themes translocations universally
Tagcloud (Intersection) ?