ARPC1B and ARPC2

Number of citations of the paper that reports this interaction (PMID 11721045)
137

Data Source:
BioGRID (affinity chromatography technology, biochemical, biochemical)
HPRD (in vitro, in vivo)

		ARPC1B	ARPC2
Gene Name		actin related protein 2/3 complex, subunit 1B, 41kDa	actin related protein 2/3 complex, subunit 2, 34kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Extracellular Vesicular Exosome	Cytoplasm Endosome Golgi Apparatus Cytosol Arp2/3 Protein Complex Plasma Membrane Focal Adhesion Actin Cytoskeleton Cell Leading Edge Neuron Projection Synapse Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Kinesin Binding AP-1 Adaptor Complex Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Movement Of Cell Or Subcellular Component Arp2/3 Complex-mediated Actin Nucleation	Movement Of Cell Or Subcellular Component Axon Guidance Positive Regulation Of Lamellipodium Assembly Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: ACTB ACTR2 APP ARPC2 ARPC4 ARPC5 AURKA PAK1 SRPK2 WAS	6 interactors: ACTR3 ARPC1B ARPC4 AURKA CORO1B WAS
Entrez ID		10095	10109
HPRD ID		10366	10367
Ensembl ID		ENSG00000130429	ENSG00000163466
Uniprot IDs		A4D275 O15143	O15144 Q53R19
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Innate Immune Response Ephrin Receptor Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Projection Morphogenesis Endocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Positive Regulation Of Organelle Organization Immune Response Defense Response Positive Regulation Of Cytoskeleton Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Neuron Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Chemotaxis Arp2/3 Complex-mediated Actin Nucleation Neuron Differentiation Positive Regulation Of Immune Response Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Actin Filament-based Process Immune System Process Actin Nucleation Vesicle-mediated Transport Regulation Of Immune Response Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Positive Regulation Of Immune System Process Regulation Of Organelle Organization Generation Of Neurons Neurogenesis Cell Development Actin Cytoskeleton Organization Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Actin Filament-based Process Actin Filament Organization	Regulation Of Cytoskeleton Organization Actin Filament Organization Regulation Of Organelle Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Nucleation Regulation Of Cellular Component Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Movement Of Cell Or Subcellular Component Organelle Organization Fc-gamma Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Nucleation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Actin Filament Polymerization Regulation Of Protein Complex Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Projection Organization Immune Response-regulating Signaling Pathway Actin Polymerization Or Depolymerization Ephrin Receptor Signaling Pathway Negative Regulation Of Spindle Checkpoint Protein Polymerization Chemotaxis Neuron Projection Morphogenesis Positive Regulation Of Immune Response Endocytosis Protein Localization To Cell Leading Edge Spindle Assembly Involved In Female Meiosis I Cellular Component Assembly Negative Regulation Of Cytoskeleton Organization Meiotic Nuclear Division
Tagcloud ?		5q cd14 conjunction crtap cxcr4 damaged del exact exactly exert explain help ie impact lenalidomide microarray monocytes myelodysplastic necrosis niche profiling remission repressed restore stability stroma suppress tnf upregulated	10q26 alleles carrying colitis constructed contribution dra dutch ecm1 flagged gas7 genotyped gwas hla il10 il23r loci make replicated replication s100z snps susceptibility tagging ten top trend uc ulcerative
Tagcloud (Difference) ?		5q cd14 conjunction crtap cxcr4 damaged del exact exactly exert explain help ie impact lenalidomide microarray monocytes myelodysplastic necrosis niche profiling remission repressed restore stability stroma suppress tnf upregulated	10q26 alleles carrying colitis constructed contribution dra dutch ecm1 flagged gas7 genotyped gwas hla il10 il23r loci make replicated replication s100z snps susceptibility tagging ten top trend uc ulcerative
Tagcloud (Intersection) ?