VRK2 and BABAM2

Data Source: HiPPIP (Novel)

		VRK2	BABAM2
Name		VRK serine/threonine kinase 2	BRISC and BRCA1 A complex member 2
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Organelle Envelope Protein-containing Complex	Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity	Peroxisome Targeting Sequence Binding Tumor Necrosis Factor Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Phosphorylation DNA Damage Response Signal Transduction Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Signal Transduction Response To Ionizing Radiation Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination Cellular Response To Ionizing Radiation Regulation Of DNA Damage Checkpoint
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
GWAS		A body shape index ( 34021172 ) Age at first sexual intercourse ( 34211149 ) Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30643258 ) Alcohol use disorder (consumption score) ( 30940813 ) Ambidextrousness ( 32989287 ) Appendicular lean mass ( 33097823 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 33263727 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Daytime nap ( 33568662 ) Depression ( 29700475 33859377 ) Epilepsy ( 25087078 ) Experiencing mood swings ( 29500382 ) Feeling miserable ( 29500382 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) Hip circumference adjusted for BMI ( 34021172 ) Hirschsprung disease ( 27702942 ) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566 ) Insomnia symptoms (never/rarely vs. usually) ( 30804566 ) Irritable mood ( 29500382 ) Lamb consumption ( 32066663 ) Major depressive disorder ( 27479909 ) Metabolite levels ( 23823483 ) Neurociticism ( 29500382 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Problematic alcohol use ( 32451486 ) Schizophrenia ( 19571808 30285260 29483656 28991256 27922604 25056061 ) Sleep duration ( 27992416 27494321 ) Sleep duration (oversleepers vs undersleepers) ( 27494321 ) Smoking initiation ( 33082346 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for body mass index ( 34021172 )	Blond vs. brown/black hair color ( 30531825 ) Estimated glomerular filtration rate ( 31152163 ) Intraocular pressure ( 29617998 ) Low density lipoprotein cholesterol levels ( 33339817 ) Urate levels ( 31578528 ) Uterine fibroids ( 31649266 )
Novel Interactors		6 novel interactors: ASB3 BABAM2 CNTN5 DHDDS PLD3 PTTG1	1 novel interactors: VRK2
Interacting Genes		21 interacting genes: AQP6 CCT2 CCT4 CDC42 DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 OGT PLK1 RAN RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88	7 interacting genes: BABAM1 GFI1B NCOA3 PPDPF SUMO2 UBC UBE2D1
Entrez ID		7444	9577
HPRD ID		03702	08498
Ensembl ID		ENSG00000028116	ENSG00000158019
Uniprot IDs		A8K9L2 Q86Y07	Q9NXR7
PDB IDs		2V62 5UU1 6NCG 8Q1Z 9FET	6H3C 6R8F 8PVY 8PY2
GO Terms Enriched among Interactors		ScaRNA Localization To Cajal Body Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Zona Pellucida Receptor Complex Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body JNK Cascade Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida RNA Localization Positive Regulation Of Chromosome Organization ATP-dependent Protein Folding Chaperone Homologous Chromosome Segregation Regulation Of Telomere Maintenance MAPK Cascade Sperm-egg Recognition Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Protein Kinase Binding Positive Regulation Of DNA Metabolic Process Nuclear Chromosome Segregation Regulation Of Telomere Maintenance Via Telomere Lengthening Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Cell-cell Recognition Protein Folding Chaperone JUN Kinase Binding MAP-kinase Scaffold Activity Midbody Meiotic Chromosome Segregation Intracellular Signal Transduction Cardiac Conduction System Development Regulation Of Biological Quality Regulation Of Protein Stability MAP Kinase Activity Cell Body Magnesium Ion Binding Regulation Of DNA Biosynthetic Process Regulation Of Protein Localization Protein Stabilization Positive Regulation Of Protein Localization Embryonic Heart Tube Development Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade	Protein Tag Activity TORC1 Signaling Organelle Envelope