VRK2 and LNX1

Number of citations of the paper that reports this interaction (PMID 22889411)
1

Data Source:
BioGRID (two hybrid)

		VRK2	LNX1
Gene Name		vaccinia related kinase 2	ligand of numb-protein X 1, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane	Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity PDZ Domain Binding
	Biological Process	Protein Phosphorylation Endocytosis Regulation Of Cell Shape Viral Process Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Schizophrenia ( 19571808)	DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		10 interactors: CCT2 CCT4 CDC42 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 RBX1 TCP1	218 interactors: ABCA1 ABCB1 ABR ACAT2 ACY3 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L APIP APOL4 APP ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKC BCR BLVRA BPIFA1 C1QTNF1 CA8 CALCOCO2 CAMK2N2 CATSPERD CCDC101 CCDC102B CCDC114 CCDC85B CDA CDC42EP4 CEP72 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK2 COIL CPNE2 CTBP1 CTNND2 CTSO CUTC CXADR DAB1 DAPK1 DCTD DCUN1D5 DDX17 DEPTOR DNPEP DOCK9 DPF2 DVL3 EBF4 EHMT2 EIF4H ENOX1 EPHB3 EXOC8 FAM118A FAM124A FAM212B FAM9B FBP1 FBXL12 FHL3 GAS2L2 GDI1 GIPR GJD4 GOLPH3L GPR142 GRB2 GRIN1 HMBOX1 HOMEZ HSBP1 HTR2B HUNK IGSF5 IL3RA ILF3 INSC ISCU JOSD1 KALRN KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KHDRBS3 KIAA1598 KLHL12 KRT15 KRTAP4-12 KRTAP4-2 KRTAP9-2 KXD1 LCLAT1 LDOC1 LGALS14 LGR6 LNX2 LRRC3B LSM2 MAGEA11 MAGEB18 MAPK9 MEMO1 METTL21A MRFAP1L1 MRPS24 MTMR9 MTUS2 MUSTN1 MVB12B NADK NAGK NCK2 NECAB2 NEK6 NKD2 NME7 NOTCH2NL NRCAM NUDT14 NUMB NUP37 NXT2 ORMDL3 OSBP2 OSGIN1 PAFAH1B3 PAICS PBK PBLD PCBD1 PDZRN3 PDZRN4 PKDREJ PKM PKP4 POMGNT1 PPIA PPID PQBP1 PRR13 PTGIR PTS RABAC1 RAD51D RAD54B RBMX RBMY1A1 RFPL3 ROBO3 ROPN1 RPIA RUFY4 RUVBL2 SAPCD1 SAT1 SCLT1 SDK1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPF SPHKAP SRSF1 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 TBCEL THAP7 TIFA TMEM14C TNFRSF18 TPM4 TRAF2 TRIM23 TRIM39 TRIM54 TRIP13 TRMT12 TSC2 TSC22D4 TSSK3 TYRO3 UBE2D2 ULK2 VCP VRK2 WAC WNT8A WWP1 ZADH2 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZNF581 ZNF593
Entrez ID		7444	84708
HPRD ID		03702	17287
Ensembl ID		ENSG00000028116	ENSG00000072201
Uniprot IDs		Q86Y07	Q8TBB1
PDB IDs		2V62	3B76
Enriched GO Terms of Interacting Partners?		Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Toxin Transport Binding Of Sperm To Zona Pellucida Sperm-egg Recognition 'de Novo' Posttranslational Protein Folding MAPK Cascade 'de Novo' Protein Folding Cell-cell Recognition Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JUN Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cell Recognition Positive Regulation Of JNK Cascade Single Fertilization Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Fertilization Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Protein Folding Cellular Response To Stress Regulation Of MAP Kinase Activity Sexual Reproduction Regulation Of Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway	Cellular Component Assembly Protein Homooligomerization Protein Oligomerization Protein Complex Assembly Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Regulation Of Cellular Component Organization Cellular Aromatic Compound Metabolic Process Regulation Of Rho Protein Signal Transduction Response To Stimulus Developmental Process Cellular Metabolic Process Peptidyl-lysine Dimethylation Heterocycle Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Degranulation Cellular Response To Stimulus Viral Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Protein Tetramerization Cell Death Apoptotic Process Death Neuron Recognition Cell Communication Signaling Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Viral Release From Host Cell Regulation Of Rho GTPase Activity Cell-cell Junction Organization Protein Autophosphorylation Response To Abiotic Stimulus Organelle Organization Regulation Of Cell Morphogenesis Nitrogen Compound Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Homodimerization Activity Regulation Of Ras Protein Signal Transduction Protein Heterooligomerization Biosynthetic Process
Tagcloud ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified
Tagcloud (Difference) ?		2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified
Tagcloud (Intersection) ?