VRK2 and DHDDS

		VRK2	DHDDS
Description		VRK serine/threonine kinase 2	dehydrodolichyl diphosphate synthase subunit
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Organelle Envelope Protein-containing Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dehydrodolichyl Diphosphate Synthase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity	Prenyltransferase Activity Protein Binding Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation DNA Damage Response Signal Transduction Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Protein Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Polyprenol Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Synthesis of dolichyl-phosphate Defective DHDDS causes RP59
Drugs
Diseases
GWAS		A body shape index ( 34021172) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Ambidextrousness ( 32989287) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Depression ( 29700475 33859377) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hip circumference adjusted for BMI ( 34021172) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Problematic alcohol use ( 32451486) Schizophrenia ( 19571808 30285260 29483656 28991256 27922604 25056061) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321) Smoking initiation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Caffeine consumption from tea ( 33287642) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		21 interacting genes: AQP6 CCT2 CCT4 CDC42 DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 OGT PLK1 RAN RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88	3 interacting genes: LOX MT-ND1 NPC2
Entrez ID		7444	79947
HPRD ID		03702	12183
Ensembl ID		ENSG00000028116	ENSG00000117682
Uniprot IDs		A8K9L2 Q86Y07	Q86SQ9
PDB IDs		2V62 5UU1 6NCG 8Q1Z 9FET	6W2L 6Z1N 7PAX 7PAY 7PB0 7PB1
Enriched GO Terms of Interacting Partners?		ScaRNA Localization To Cajal Body Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Zona Pellucida Receptor Complex Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body JNK Cascade Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida RNA Localization Positive Regulation Of Chromosome Organization ATP-dependent Protein Folding Chaperone Homologous Chromosome Segregation Regulation Of Telomere Maintenance MAPK Cascade Sperm-egg Recognition Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Protein Kinase Binding Positive Regulation Of DNA Metabolic Process Nuclear Chromosome Segregation Regulation Of Telomere Maintenance Via Telomere Lengthening Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Cell-cell Recognition Protein Folding Chaperone JUN Kinase Binding MAP-kinase Scaffold Activity Midbody Meiotic Chromosome Segregation Intracellular Signal Transduction Cardiac Conduction System Development Regulation Of Biological Quality Regulation Of Protein Stability MAP Kinase Activity Cell Body Magnesium Ion Binding Regulation Of DNA Biosynthetic Process Regulation Of Protein Localization Protein Stabilization Positive Regulation Of Protein Localization Embryonic Heart Tube Development Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade	Descending Aorta Development Ascending Aorta Development Organelle Envelope Peptidyl-lysine Oxidation Response To Xenobiotic Stimulus Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Mitochondrial Membrane Cholesterol Storage Glycolipid Transport Sterol Binding Regulation Of Isoprenoid Metabolic Process Regulation Of Bone Development Elastic Fiber Assembly NADH Dehydrogenase Activity Response To Oxidative Stress Regulation Of Interleukin-1-mediated Signaling Pathway Cellular Response To Chemokine
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