VRK2 and PLD3

		VRK2	PLD3
Description		VRK serine/threonine kinase 2	phospholipase D family member 3
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Organelle Envelope Protein-containing Complex	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endosome Membrane Endomembrane System Membrane Early Endosome Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity	Catalytic Activity Nuclease Activity Exonuclease Activity Phospholipase D Activity Protein Binding Hydrolase Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity
	Biological Process	Protein Phosphorylation DNA Damage Response Signal Transduction Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Immune System Process DNA Metabolic Process Lipid Metabolic Process Inflammatory Response Myotube Differentiation Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Synthesis of PG Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Ambidextrousness ( 32989287) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Depression ( 29700475 33859377) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hip circumference adjusted for BMI ( 34021172) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Problematic alcohol use ( 32451486) Schizophrenia ( 19571808 30285260 29483656 28991256 27922604 25056061) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321) Smoking initiation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)
Interacting Genes		21 interacting genes: AQP6 CCT2 CCT4 CDC42 DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 OGT PLK1 RAN RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88	13 interacting genes: ANXA7 BCL2L1 CNIH3 GPR35 HGS NFKB1 OGT OPRM1 SMCO4 SOX4 SPP1 STK11 TK1
Entrez ID		7444	23646
HPRD ID		03702	07148
Ensembl ID		ENSG00000028116	ENSG00000105223
Uniprot IDs		A8K9L2 Q86Y07	Q8IV08
PDB IDs		2V62 5UU1 6NCG 8Q1Z 9FET	8Q1K 8Q1X 8S86 8V5T
Enriched GO Terms of Interacting Partners?		ScaRNA Localization To Cajal Body Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Zona Pellucida Receptor Complex Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body JNK Cascade Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida RNA Localization Positive Regulation Of Chromosome Organization ATP-dependent Protein Folding Chaperone Homologous Chromosome Segregation Regulation Of Telomere Maintenance MAPK Cascade Sperm-egg Recognition Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Protein Kinase Binding Positive Regulation Of DNA Metabolic Process Nuclear Chromosome Segregation Regulation Of Telomere Maintenance Via Telomere Lengthening Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Cell-cell Recognition Protein Folding Chaperone JUN Kinase Binding MAP-kinase Scaffold Activity Midbody Meiotic Chromosome Segregation Intracellular Signal Transduction Cardiac Conduction System Development Regulation Of Biological Quality Regulation Of Protein Stability MAP Kinase Activity Cell Body Magnesium Ion Binding Regulation Of DNA Biosynthetic Process Regulation Of Protein Localization Protein Stabilization Positive Regulation Of Protein Localization Embryonic Heart Tube Development Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade	Regulation Of Transport Autophagy Negative Regulation Of Developmental Process Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Process Regulation Of Neurotransmitter Receptor Activity Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Alkaloid Mitochondrial Membrane Regulation Of Signal Transduction Apoptotic Process In Bone Marrow Cell Positive Regulation Of Transport Regulation Of Signaling Receptor Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Cell Growth Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macroautophagy Vacuole-isolation Membrane Contact Site Response To Ketone Regulation Of Protein Localization Negative Regulation Of Growth Synapse Regulation Of Cellular Response To Stress Protein Localization To Lysosome Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Reproductive Process Regulation Of Canonical Wnt Signaling Pathway NF-kappaB P50/p65 Complex Regulation Of Secretion By Cell Cellular Response To Glucose Stimulus Positive Regulation Of Estradiol Secretion Thymidine Kinase Activity C-terminal Protein Lipidation Regulation Of Growth Mitochondrion Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Positive Regulation Of Lipid Transport Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex
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