VRK2 and PTTG1

Data Source: HiPPIP (Novel)

		VRK2	PTTG1
Name		VRK serine/threonine kinase 2	PTTG1 regulator of sister chromatid separation, securin
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Organelle Envelope Protein-containing Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding Molecular Function Activator Activity
	Biological Process	Protein Phosphorylation DNA Damage Response Signal Transduction Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	DNA Repair DNA Damage Response Chromosome Segregation Spermatogenesis Homologous Chromosome Segregation Chromosome Organization Cell Division
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids
GWAS		A body shape index ( 34021172 ) Age at first sexual intercourse ( 34211149 ) Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30643258 ) Alcohol use disorder (consumption score) ( 30940813 ) Ambidextrousness ( 32989287 ) Appendicular lean mass ( 33097823 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 33263727 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Daytime nap ( 33568662 ) Depression ( 29700475 33859377 ) Epilepsy ( 25087078 ) Experiencing mood swings ( 29500382 ) Feeling miserable ( 29500382 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) Hip circumference adjusted for BMI ( 34021172 ) Hirschsprung disease ( 27702942 ) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566 ) Insomnia symptoms (never/rarely vs. usually) ( 30804566 ) Irritable mood ( 29500382 ) Lamb consumption ( 32066663 ) Major depressive disorder ( 27479909 ) Metabolite levels ( 23823483 ) Neurociticism ( 29500382 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Problematic alcohol use ( 32451486 ) Schizophrenia ( 19571808 30285260 29483656 28991256 27922604 25056061 ) Sleep duration ( 27992416 27494321 ) Sleep duration (oversleepers vs undersleepers) ( 27494321 ) Smoking initiation ( 33082346 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for body mass index ( 34021172 )	Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Insulin-related traits ( 22791750 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 19838195 21408207 28714469 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 )
Novel Interactors		6 novel interactors: ASB3 BABAM2 CNTN5 DHDDS PLD3 PTTG1	1 novel interactors: VRK2
Interacting Genes		21 interacting genes: AQP6 CCT2 CCT4 CDC42 DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 OGT PLK1 RAN RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88	29 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC4 AURKA CAMK2A CDC20 CDC27 CDC34 CDH1 CDK1 CFTR CRK CUL1 DNAJA1 FZR1 KEAP1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2N UBE4A UBR5 XRCC6 ZFAND5
Entrez ID		7444	9232
HPRD ID		03702	04998
Ensembl ID		ENSG00000028116	ENSG00000164611
Uniprot IDs		A8K9L2 Q86Y07	O95997 Q6IAL9
PDB IDs		2V62 5UU1 6NCG 8Q1Z 9FET	7NJ0 7NJ1
GO Terms Enriched among Interactors		ScaRNA Localization To Cajal Body Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Zona Pellucida Receptor Complex Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body JNK Cascade Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida RNA Localization Positive Regulation Of Chromosome Organization ATP-dependent Protein Folding Chaperone Homologous Chromosome Segregation Regulation Of Telomere Maintenance MAPK Cascade Sperm-egg Recognition Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Protein Kinase Binding Positive Regulation Of DNA Metabolic Process Nuclear Chromosome Segregation Regulation Of Telomere Maintenance Via Telomere Lengthening Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Cell-cell Recognition Protein Folding Chaperone JUN Kinase Binding MAP-kinase Scaffold Activity Midbody Meiotic Chromosome Segregation Intracellular Signal Transduction Cardiac Conduction System Development Regulation Of Biological Quality Regulation Of Protein Stability MAP Kinase Activity Cell Body Magnesium Ion Binding Regulation Of DNA Biosynthetic Process Regulation Of Protein Localization Protein Stabilization Positive Regulation Of Protein Localization Embryonic Heart Tube Development Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade	Proteasomal Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Anaphase-promoting Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Protein Ubiquitination Protein Branched Polyubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Meiotic Cell Cycle Macromolecule Catabolic Process Regulation Of Chromosome Segregation Proteolysis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Regulation Of Cell Cycle Process Catabolic Process Cell Division Cytosol Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Protein Metabolic Process Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Response To Oxidative Stress Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Protein-containing Complex Ubiquitin-protein Transferase Activator Activity Regulation Of Cell Cycle Phase Transition Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Cullin-RING Ubiquitin Ligase Complex