ACVR1 and FGD6

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		ACVR1	FGD6
Description		activin A receptor type 1	FYVE, RhoGEF and PH domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Part Of Cell Activin Receptor Complex BMP Receptor Complex	Ruffle Cytoplasm Golgi Apparatus Cytoskeleton Lamellipodium
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Peptide Hormone Binding Growth Factor Binding Protein Homodimerization Activity Cadherin Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Outflow Tract Septum Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Formation Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Gastrulation Mesoderm Development Heart Development Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Ossification Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Pharyngeal System Development Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epithelial Tube Morphogenesis Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Circulatory System Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Determination Of Dorsal Identity Regulation Of Multicellular Organismal Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly
Pathways
Drugs		ATP Dorsomorphin Fostamatinib
Diseases		Fibrodysplasia ossificans progressiva (FOP)
GWAS		A body shape index ( 34021172) Severe gingival inflammation ( 28459102) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 29212778 33020668) Exudative age-related macular degeneration ( 25629512) Hip circumference ( 28552196) Intracranial aneurysm ( 33199917) Lung function (FEV1/FVC) ( 28166213 30804560) Platelet count ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30224653) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		70 interacting genes: AP2B1 BAMBI BMP2 BMP6 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP CRIPTO DCAF6 DUSP13B ENG FANCL FBXO30 FBXO7 FCHO1 FGD6 FKBP4 FNTA GDF2 GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 OTUB1 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SKIC8 SMAD1 SMAD5 SMAD9 SOCS6 STIP1 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1	2 interacting genes: ACVR1 YWHAG
Entrez ID		90	55785
HPRD ID		00021	16892
Ensembl ID		ENSG00000115170	ENSG00000180263
Uniprot IDs		D3DPA4 Q04771	Q6ZV73
PDB IDs		3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM 5OXG 5OY6 5S75 5S76 5S77 5S78 5S79 5S7A 5S7B 5S7C 5S7D 5S7E 5S7F 5S7G 5S7H 5S7I 5S7J 5S7K 5S7L 5S7M 5S7N 5S7O 5S7P 5S7Q 5S7R 5S7S 5S7T 5S7U 5S7V 5S7W 5S7X 5S7Y 5S7Z 5S80 5S81 5S82 5S83 5S84 5S85 5S86 5S87 5S88 5S89 5S8A 5S8B 5S9K 6ACR 6EIX 6GI6 6GIN 6GIP 6I1S 6JUX 6SRH 6SZM 6T6D 6T8N 6TN8 6UNQ 6UNR 6UNS 6Z36 6ZGC 7A21 7C3G 7NNS 7YRU 8C7W 8C7Z 8POD 8R7G 8UWR 9D8E 9D8F 9D8Z
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway GTP Binding Signal Transduction Regulation Of Signal Transduction Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus GTPase Activity Regulation Of Intracellular Signal Transduction Osteoblast Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Response To Growth Factor Cartilage Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Growth Factor Stimulus Positive Regulation Of Ossification Positive Regulation Of Cartilage Development Growth Factor Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation GDP Binding Regulation Of Bone Mineralization Nucleotide Binding Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction SMAD Protein Signal Transduction Enzyme Activator Complex Intracellular Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Heart Development Regulation Of Osteoblast Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Tricuspid Valve Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Intracellular Signaling Cassette Morphogenesis Of A Branching Structure Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation	Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Endocardial Cushion Cell Fate Commitment Endocardial Cushion Formation Atrial Septum Primum Morphogenesis Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Endocardial Cushion Fusion Activin Binding BMP Receptor Activity Cardiac Muscle Cell Fate Commitment Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Epithelial Cell Fate Commitment Mitral Valve Morphogenesis BMP Receptor Complex Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Kinase C Inhibitor Activity Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding Muscle Cell Fate Commitment Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Activin Receptor Signaling Pathway Atrial Septum Morphogenesis Regulation Of T Cell Mediated Immune Response To Tumor Cell Insulin-like Growth Factor Receptor Binding Gastrulation With Mouth Forming Second Pharyngeal System Development Positive Regulation Of Immune Response To Tumor Cell Transforming Growth Factor Beta Binding Atrioventricular Valve Morphogenesis Circulatory System Development Regulation Of Activin Receptor Signaling Pathway Protein K6-linked Ubiquitination Smooth Muscle Cell Differentiation Outflow Tract Septum Morphogenesis Endothelial Cell Differentiation Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Response To Tumor Cell Branching Involved In Blood Vessel Morphogenesis Positive Regulation Of Intracellular Signal Transduction Peptide Hormone Binding Negative Regulation Of T Cell Mediated Immunity Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Protein Tyrosine Kinase Binding Positive Regulation Of Bone Mineralization Protein Sequestering Activity
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