ACVR1 and BMP2

Number of citations of the paper that reports this interaction (PubMedID 8006002)
0

Data Source:
HPRD (in vivo)

		ACVR1	BMP2
Description		activin A receptor type 1	bone morphogenetic protein 2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Part Of Cell Activin Receptor Complex BMP Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Cilium Cell Surface BMP Receptor Complex Enzyme Activator Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Peptide Hormone Binding Growth Factor Binding Protein Homodimerization Activity Cadherin Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Phosphatase Activator Activity Co-receptor Binding Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity BMP Receptor Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Outflow Tract Septum Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Formation Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Gastrulation Mesoderm Development Heart Development Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Ossification Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Pharyngeal System Development Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epithelial Tube Morphogenesis Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Circulatory System Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Determination Of Dorsal Identity Regulation Of Multicellular Organismal Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Chondrocyte Differentiation Myeloid Leukocyte Differentiation Heart Morphogenesis Heart Induction Endodermal-mesodermal Cell Signaling Aortic Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Atrium Formation Endocardial Cushion Formation Positive Regulation Of Extracellular Matrix Constituent Secretion Proteoglycan Metabolic Process Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Bacterium Animal Organ Morphogenesis Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Negative Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Protein Destabilization Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Cell Proliferation Astrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Negative Regulation Of Muscle Cell Differentiation Cartilage Development Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Bone Development Positive Regulation Of SMAD Protein Signal Transduction Lung Vasculature Development Mesenchyme Development Muscle Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Odontoblast Differentiation Positive Regulation Of MiRNA Transcription Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cortisol Biosynthetic Process Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways			Signaling by BMP Molecules associated with elastic fibres Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity
Drugs		ATP Dorsomorphin Fostamatinib
Diseases		Fibrodysplasia ossificans progressiva (FOP)
GWAS		A body shape index ( 34021172) Severe gingival inflammation ( 28459102) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult body size ( 32376654) Atrial fibrillation ( 29892015) Axial length ( 24144296) Body mass index ( 19079261 25673413 23669352 28892062) Body size at age 10 ( 32376654) Childhood ear infection ( 27182965) Colorectal cancer ( 23266556 29471430 24737748 30529582 31826910 25990418 26151821) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Height ( 31562340 25429064 25282103 23563607 18391951 20881960) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30804560 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Major depressive disorder (stressful life events interaction) ( 26845276) Mitochondrial heteroplasmy measurement ( 33731350) Nose morphology (partial least square model) ( 30174134) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QRS complex (Cornell) ( 27659466) Refractive error ( 23396134 32231278) Retinal detachment or retinal break ( 31816047) Sagittal craniosynostosis ( 23160099) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels x loop diuretics use interaction ( 31806883) Vertical cup-disc ratio ( 28073927 25241763 31798171) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		70 interacting genes: AP2B1 BAMBI BMP2 BMP6 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP CRIPTO DCAF6 DUSP13B ENG FANCL FBXO30 FBXO7 FCHO1 FGD6 FKBP4 FNTA GDF2 GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 OTUB1 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SKIC8 SMAD1 SMAD5 SMAD9 SOCS6 STIP1 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1	21 interacting genes: ACTR2 ACVR1 ACVR2A ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG RGMB SOSTDC1 TGFB1 TGFB2
Entrez ID		90	650
HPRD ID		00021	00206
Ensembl ID		ENSG00000115170	ENSG00000125845
Uniprot IDs		D3DPA4 Q04771	C8C060 P12643
PDB IDs		3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM 5OXG 5OY6 5S75 5S76 5S77 5S78 5S79 5S7A 5S7B 5S7C 5S7D 5S7E 5S7F 5S7G 5S7H 5S7I 5S7J 5S7K 5S7L 5S7M 5S7N 5S7O 5S7P 5S7Q 5S7R 5S7S 5S7T 5S7U 5S7V 5S7W 5S7X 5S7Y 5S7Z 5S80 5S81 5S82 5S83 5S84 5S85 5S86 5S87 5S88 5S89 5S8A 5S8B 5S9K 6ACR 6EIX 6GI6 6GIN 6GIP 6I1S 6JUX 6SRH 6SZM 6T6D 6T8N 6TN8 6UNQ 6UNR 6UNS 6Z36 6ZGC 7A21 7C3G 7NNS 7YRU 8C7W 8C7Z 8POD 8R7G 8UWR 9D8E 9D8F 9D8Z	1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP 4MID 4N1D 4UHY 4UHZ 4UI0 4UI1 4UI2 6OMN 7AG0 8E3G
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway GTP Binding Signal Transduction Regulation Of Signal Transduction Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus GTPase Activity Regulation Of Intracellular Signal Transduction Osteoblast Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Response To Growth Factor Cartilage Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Growth Factor Stimulus Positive Regulation Of Ossification Positive Regulation Of Cartilage Development Growth Factor Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation GDP Binding Regulation Of Bone Mineralization Nucleotide Binding Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction SMAD Protein Signal Transduction Enzyme Activator Complex Intracellular Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Heart Development Regulation Of Osteoblast Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Tricuspid Valve Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Intracellular Signaling Cassette Morphogenesis Of A Branching Structure Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway BMP Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Binding Regulation Of SMAD Protein Signal Transduction BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To BMP Stimulus Pattern Specification Process Regulation Of Ossification Response To Growth Factor Regulation Of Bone Mineralization Regulation Of Osteoblast Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Regulation Of BMP Signaling Pathway System Development Dorsal/ventral Pattern Formation Negative Regulation Of BMP Signaling Pathway Animal Organ Morphogenesis Tissue Development Positive Regulation Of Bone Mineralization Regulation Of Signal Transduction Embryonic Morphogenesis Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Animal Organ Development Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Differentiation Outflow Tract Septum Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Activin Receptor Signaling Pathway Regulation Of Developmental Process Cardiac Septum Morphogenesis Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Positive Regulation Of Developmental Process Activin Binding Pharyngeal Arch Artery Morphogenesis Ventricular Septum Morphogenesis Activin Receptor Activity, Type II
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