ACVR1 and UBA52

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		ACVR1	UBA52
Description		activin A receptor type 1	ubiquitin A-52 residue ribosomal protein fusion product 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Part Of Cell Activin Receptor Complex BMP Receptor Complex	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Ribosome Plasma Membrane Endosome Membrane Large Ribosomal Subunit Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Endocytic Vesicle Membrane Vesicle Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Peptide Hormone Binding Growth Factor Binding Protein Homodimerization Activity Cadherin Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Structural Constituent Of Ribosome Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Outflow Tract Septum Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Formation Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Gastrulation Mesoderm Development Heart Development Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Ossification Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Pharyngeal System Development Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epithelial Tube Morphogenesis Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Circulatory System Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Determination Of Dorsal Identity Regulation Of Multicellular Organismal Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cytoplasmic Translation Translation Protein Ubiquitination Response To Insecticide Modification-dependent Protein Catabolic Process Protein Modification Process
Pathways			Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Viral mRNA Translation Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Downstream TCR signaling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Regulation of activated PAK-2p34 by proteasome mediated degradation NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Selenocysteine synthesis Separation of Sister Chromatids Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Stimuli-sensing channels Constitutive Signaling by NOTCH1 HD Domain Mutants FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA Glycogen synthesis Autodegradation of the E3 ubiquitin ligase COP1 Deactivation of the beta-catenin transactivating complex Myoclonic epilepsy of Lafora ABC-family proteins mediated transport TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Regulation of FZD by ubiquitination PINK1-PRKN Mediated Mitophagy N-glycan trimming in the ER and Calnexin/Calreticulin cycle Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Hedgehog 'on' state Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway Negative regulation of MAPK pathway Regulation of necroptotic cell death NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAP3K8 (TPL2)-dependent MAPK1/3 activation HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases UCH proteinases Josephin domain DUBs Ub-specific processing proteases Ovarian tumor domain proteases Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Major pathway of rRNA processing in the nucleolus and cytosol Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Negative regulation of MET activity Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Cyclin D associated events in G1 G2/M Checkpoints Stabilization of p53 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling VLDLR internalisation and degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell InlA-mediated entry of Listeria monocytogenes into host cells RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN localization Regulation of PTEN stability and activity Neddylation ER Quality Control Compartment (ERQC) Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling Peroxisomal protein import Peroxisomal protein import Interferon alpha/beta signaling Regulation of signaling by CBL Endosomal Sorting Complex Required For Transport (ESCRT) Iron uptake and transport Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Negative regulation of NOTCH4 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Response of EIF2AK4 (GCN2) to amino acid deficiency Prevention of phagosomal-lysosomal fusion Modulation by Mtb of host immune system Alpha-protein kinase 1 signaling pathway Aggrephagy Aggrephagy RAS processing Pexophagy Signaling by CSF1 (M-CSF) in myeloid cells Maturation of protein E SARS-CoV-1 activates/modulates innate immune responses Maturation of protein E Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Negative regulation of FLT3 FLT3 signaling by CBL mutants Regulation of BACH1 activity Signaling by ALK fusions and activated point mutants TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation KEAP1-NFE2L2 pathway Regulation of NF-kappa B signaling Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Amyloid fiber formation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Regulation of pyruvate metabolism GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PD-L1(CD274) glycosylation and translocation to plasma membrane Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		ATP Dorsomorphin Fostamatinib
Diseases		Fibrodysplasia ossificans progressiva (FOP)
GWAS		A body shape index ( 34021172) Severe gingival inflammation ( 28459102) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		70 interacting genes: AP2B1 BAMBI BMP2 BMP6 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP CRIPTO DCAF6 DUSP13B ENG FANCL FBXO30 FBXO7 FCHO1 FGD6 FKBP4 FNTA GDF2 GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 OTUB1 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SKIC8 SMAD1 SMAD5 SMAD9 SOCS6 STIP1 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1	44 interacting genes: ACVR1 ARRDC3 BMPR1B DAZAP2 DESI1 DNAJB2 EPN2 EPN3 FAM168A FILNC1 FNDC3B FSHR GRB2 HERC3 HGS KHDRBS1 LAPTM5 LITAF MAPK6 MTURN NCK1 PLEKHB2 PLSCR4 POLI RABGEF1 RAD23A RNF11 SEC23B SLC2A4 SMAD1 SMAD2 SMAD4 SMURF1 SNCA SQSTM1 TAX1BP1 TGFBR1 TSG101 UBQLN1 UBQLN2 USP46 USP7 VPS28 WBP2
Entrez ID		90	7311
HPRD ID		00021	08931
Ensembl ID		ENSG00000115170	ENSG00000221983
Uniprot IDs		D3DPA4 Q04771	P62987 Q3MIH3 Q7Z4P3
PDB IDs		3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM 5OXG 5OY6 5S75 5S76 5S77 5S78 5S79 5S7A 5S7B 5S7C 5S7D 5S7E 5S7F 5S7G 5S7H 5S7I 5S7J 5S7K 5S7L 5S7M 5S7N 5S7O 5S7P 5S7Q 5S7R 5S7S 5S7T 5S7U 5S7V 5S7W 5S7X 5S7Y 5S7Z 5S80 5S81 5S82 5S83 5S84 5S85 5S86 5S87 5S88 5S89 5S8A 5S8B 5S9K 6ACR 6EIX 6GI6 6GIN 6GIP 6I1S 6JUX 6SRH 6SZM 6T6D 6T8N 6TN8 6UNQ 6UNR 6UNS 6Z36 6ZGC 7A21 7C3G 7NNS 7YRU 8C7W 8C7Z 8POD 8R7G 8UWR 9D8E 9D8F 9D8Z	2LJ5 2MBH 2MJB 2MUR 2N3U 2N3V 2N3W 2NBD 2NBE 2RSU 4HJK 4JIO 4P4H 4PIG 4PIH 4PIJ 4RF0 4RF1 4S1Z 4UG0 4V6X 4XKL 5AJ0 5GO7 5GO8 5GOB 5GOC 5GOD 5GOG 5GOH 5GOI 5GOJ 5GOK 5HPK 5HPL 5HPS 5HPT 5J26 5J8P 5JBV 5JBY 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7AY1 7BHP 7F5S 7M3Q 7OWC 7UN3 7WFC 7XD0 7XNX 7XNY 7ZF1 7ZH3 7ZH4 8A3D 8IFD 8IFE 8IK6 8IKM 8IKT 8IKV 8IPJ 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway GTP Binding Signal Transduction Regulation Of Signal Transduction Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus GTPase Activity Regulation Of Intracellular Signal Transduction Osteoblast Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Response To Growth Factor Cartilage Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Growth Factor Stimulus Positive Regulation Of Ossification Positive Regulation Of Cartilage Development Growth Factor Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation GDP Binding Regulation Of Bone Mineralization Nucleotide Binding Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction SMAD Protein Signal Transduction Enzyme Activator Complex Intracellular Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Heart Development Regulation Of Osteoblast Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Tricuspid Valve Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Intracellular Signaling Cassette Morphogenesis Of A Branching Structure Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation	Endosome I-SMAD Binding SMAD Binding Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Protein Localization To Vacuole Transforming Growth Factor Beta Receptor Activity, Type I Ubiquitin Binding Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Complex Regulation Of Protein Ubiquitination Heteromeric SMAD Protein Complex Ubiquitin Protein Ligase Binding Cytoplasm Activin Receptor Signaling Pathway Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process Modification-dependent Protein Catabolic Process BMP Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Regulation Of Post-translational Protein Modification Transmembrane Receptor Protein Serine/threonine Kinase Activity Vacuolar Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Sequestering Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Proteolysis Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Homomeric SMAD Protein Complex Positive Regulation Of Ubiquitin-dependent Endocytosis Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Targeting To Vacuole
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