VCAM1 and ETFA

Data Source: HiPPIP (Novel)

		VCAM1	ETFA
Name		vascular cell adhesion molecule 1	electron transfer flavoprotein subunit alpha
Structure
GO Annotations	Cellular Component	Podosome Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane Filopodium Sarcolemma Apical Part Of Cell Extracellular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex	Mitochondrion Mitochondrial Matrix Electron Transfer Flavoprotein Complex
	Molecular Function	Integrin Binding Primary Methylamine Oxidase Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity	Protein Binding Electron Transfer Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Response To Hypoxia Chronic Inflammatory Response Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Response To Nutrient Amine Metabolic Process Response To Zinc Ion Response To Ionizing Radiation Membrane To Membrane Docking B Cell Differentiation Response To Lipopolysaccharide Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Response To Nicotine Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Response To Ethanol Leukocyte Tethering Or Rolling Cell Chemotaxis Innervation Cardiac Neuron Differentiation Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion Cellular Response To Amyloid-beta	Amino Acid Catabolic Process Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	Respiratory electron transport
Drugs		Ethanol Carvedilol Succinobucol Clove oil	None
Diseases		None	Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 21833088 24076602 31604244 ) Neutrophil percentage of white cells ( 32888494 ) Sjögren's syndrome ( 24097067 )	Diverticular disease ( 30177863 ) Glioma ( 28346443 ) Heel bone mineral density ( 30598549 ) Non-glioblastoma glioma ( 26424050 28346443 ) Response to tocilizumab in rheumatoid arthritis ( 22491018 )
Novel Interactors		2 novel interactors: ETFA EXOSC2	10 novel interactors: BNC1 CHRNA3 COX7C CSK CYP11A1 FAH LINC00597 MOV10L1 TNFRSF11A VCAM1
Interacting Genes		13 interacting genes: CCL17 CCL22 CTSG ELANE EZR IL13 ITGAD ITGB1 ITGB7 MSN TRIM54 TRIM65 USP2	7 interacting genes: CDC42 CFTR ETFB FBXL17 HSPB2 PSEN1 VHL
Entrez ID		7412	2108
HPRD ID		01888	01979
Ensembl ID		ENSG00000162692	ENSG00000140374
Uniprot IDs		P19320	A0A0S2Z3L0 P13804
PDB IDs		1IJ9 1VCA 1VSC	1EFV 1T9G 2A1T 2A1U
GO Terms Enriched among Interactors		Immune System Process Immune Response Leukocyte Cell-cell Adhesion Leukocyte Migration Cell Adhesion Molecule Binding Integrin Complex Killing Of Cells Of Another Organism Inflammatory Response Heterotypic Cell-cell Adhesion Cell Migration Defense Response Membrane To Membrane Docking Cell Motility Response To Other Organism Cell Killing Defense Response To Symbiont Positive Regulation Of Early Endosome To Late Endosome Transport Defense Response To Other Organism Positive Regulation Of Protein Localization To Early Endosome Neutrophil-mediated Killing Of Bacterium Filopodium Cell-cell Adhesion Positive Regulation Of Protein Localization To Endosome Response To External Biotic Stimulus Uropod Integrin-mediated Signaling Pathway Cell-matrix Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Mononuclear Cell Migration Regulation Of Early Endosome To Late Endosome Transport Extracellular Space Leukocyte Tethering Or Rolling Neutrophil Mediated Immunity Cell Surface Establishment Of Apical/basal Cell Polarity Leukocyte Adhesion To Vascular Endothelial Cell Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Cell Adhesion Mediated By Integrin Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell-substrate Adhesion Antimicrobial Humoral Response Killing By Host Of Symbiont Cells Cytokine-mediated Signaling Pathway Focal Adhesion T Cell Migration Biological Process Involved In Interaction With Symbiont	None