ETFA and COX7C

Data Source: HiPPIP (Novel)

		ETFA	COX7C
Name		electron transfer flavoprotein subunit alpha	cytochrome c oxidase subunit 7C
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Electron Transfer Flavoprotein Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	Protein Binding Electron Transfer Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Protein Binding
	Biological Process	Amino Acid Catabolic Process Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration
Pathways		Respiratory electron transport	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly
Drugs		None	Cholic Acid N-Formylmethionine
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	None
GWAS		Diverticular disease ( 30177863 ) Glioma ( 28346443 ) Heel bone mineral density ( 30598549 ) Non-glioblastoma glioma ( 26424050 28346443 ) Response to tocilizumab in rheumatoid arthritis ( 22491018 )	Blood trace element (Cu levels) ( 23720494 ) Uterine fibroid size (maximum dimension) ( 30196971 )
Novel Interactors		10 novel interactors: BNC1 CHRNA3 COX7C CSK CYP11A1 FAH LINC00597 MOV10L1 TNFRSF11A VCAM1	2 novel interactors: ETFA MEF2C
Interacting Genes		7 interacting genes: CDC42 CFTR ETFB FBXL17 HSPB2 PSEN1 VHL	3 interacting genes: CIDEB MAGEA2 MAGEA2B
Entrez ID		2108	1350
HPRD ID		01979	04800
Ensembl ID		ENSG00000140374	ENSG00000127184
Uniprot IDs		A0A0S2Z3L0 P13804	P15954
PDB IDs		1EFV 1T9G 2A1T 2A1U	5Z62
GO Terms Enriched among Interactors		None	Negative Regulation Of Protein Acetylation Negative Regulation Of Protein Sumoylation Histone Deacetylase Binding Positive Regulation Of Ubiquitin-protein Transferase Activity DNA-binding Transcription Factor Binding Regulation Of Protein Sumoylation Regulation Of Ubiquitin-protein Transferase Activity Cellular Senescence Negative Regulation Of Post-translational Protein Modification Sinoatrial Valve Morphogenesis Electron Transfer Flavoprotein Complex Signal Transduction By P53 Class Mediator Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction PML Body Muscle Cell Fate Determination Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Positive Regulation Of Macrophage Apoptotic Process Primary Heart Field Specification Glomerulus Morphogenesis Regulation Of Synaptic Activity Regulation Of Protein Ubiquitination Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis AMPA Selective Glutamate Receptor Signaling Pathway Lipid Droplet Fusion Negative Regulation Of Transcription By RNA Polymerase II NMDA Selective Glutamate Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Regulation Of Post-translational Protein Modification Positive Regulation Of Behavioral Fear Response Positive Regulation Of Fear Response Cardiac Ventricle Formation Regulation Of Germinal Center Formation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Ubiquitin Protein Ligase Binding Cellular Response To Parathyroid Hormone Stimulus Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Skeletal Muscle Cell Differentiation Cellular Response To Antibiotic Cardiac Chamber Formation Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Myeloid Cell Apoptotic Process Germinal Center Formation Regulation Of Behavioral Fear Response Secondary Heart Field Specification Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Catalytic Activity Negative Regulation Of Vascular Endothelial Cell Proliferation