ETFA and ETFB

Number of citations: 172 (PubMedID 40437099)
Data Source: BioGRID (affinity chromatography technology, biochemical, cross-linking study, biochemical), HPRD (in vivo)

		ETFA	ETFB
Name		electron transfer flavoprotein subunit alpha	electron transfer flavoprotein subunit beta
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Electron Transfer Flavoprotein Complex	Mitochondrion Mitochondrial Matrix Electron Transfer Flavoprotein Complex
	Molecular Function	Protein Binding Electron Transfer Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Protein Binding Electron Transfer Activity
	Biological Process	Amino Acid Catabolic Process Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase	Amino Acid Catabolic Process Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		Respiratory electron transport	Respiratory electron transport Protein methylation
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Diverticular disease ( 30177863 ) Glioma ( 28346443 ) Heel bone mineral density ( 30598549 ) Non-glioblastoma glioma ( 26424050 28346443 ) Response to tocilizumab in rheumatoid arthritis ( 22491018 )	No GWAS studies recorded
Novel Interactors		10 novel interactors: BNC1 CHRNA3 COX7C CSK CYP11A1 FAH LINC00597 MOV10L1 TNFRSF11A VCAM1	None recorded
Interacting Genes		7 interacting genes: CDC42 CFTR ETFB FBXL17 HSPB2 PSEN1 VHL	3 interacting genes: APP CRYAA ETFA
Entrez ID		2108	2109
HPRD ID		01979	00557
Ensembl ID		ENSG00000140374	ENSG00000105379
Uniprot IDs		A0A0S2Z3L0 P13804	P38117
PDB IDs		1EFV 1T9G 2A1T 2A1U	1EFV 1T9G 2A1T 2A1U
GO Terms Enriched among Interactors		None	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Electron Transfer Flavoprotein Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission Response To Light Stimulus NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Lens Fiber Cell Morphogenesis Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Regulation Of Growth Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel