ETFA and TNFRSF11A

Data Source: HiPPIP (Novel)

		ETFA	TNFRSF11A
Name		electron transfer flavoprotein subunit alpha	TNF receptor superfamily member 11a
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Electron Transfer Flavoprotein Complex	Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft
	Molecular Function	Protein Binding Electron Transfer Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Amino Acid Catabolic Process Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase	Ossification Adaptive Immune Response Immune System Process Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Osteoclast Differentiation Response To Lipopolysaccharide Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Zinc Ion Starvation Response To Tumor Necrosis Factor Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Ethanol Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of JNK Cascade Lymph Node Development Circadian Temperature Homeostasis Mammary Gland Alveolus Development Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Multinuclear Osteoclast Differentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Respiratory electron transport	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		None	ENMD-1198
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Diverticular disease ( 30177863 ) Glioma ( 28346443 ) Heel bone mineral density ( 30598549 ) Non-glioblastoma glioma ( 26424050 28346443 ) Response to tocilizumab in rheumatoid arthritis ( 22491018 )	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma ( 32296059 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Blood protein levels ( 30072576 ) Bone mineral density (paediatric, skull) ( 24945404 ) Bone mineral density (spine) ( 19801982 ) Femoral neck bone mineral density ( 29499414 ) Heel bone mineral density ( 28869591 30598549 ) Lumbar spine bone mineral density ( 29499414 22504420 ) Myasthenia gravis ( 25643325 ) Paget's disease ( 20436471 21623375 ) Response to antipsychotic treatment ( 23241943 ) Serum albumin levels ( 23022100 ) Serum alkaline phosphatase levels ( 29403010 33339817 33547301 ) Vitiligo ( 27723757 )
Novel Interactors		10 novel interactors: BNC1 CHRNA3 COX7C CSK CYP11A1 FAH LINC00597 MOV10L1 TNFRSF11A VCAM1	1 novel interactors: ETFA
Interacting Genes		7 interacting genes: CDC42 CFTR ETFB FBXL17 HSPB2 PSEN1 VHL	13 interacting genes: CBL CBLB FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		2108	8792
HPRD ID		01979	04609
Ensembl ID		ENSG00000140374	ENSG00000141655
Uniprot IDs		A0A0S2Z3L0 P13804	Q9Y6Q6
PDB IDs		1EFV 1T9G 2A1T 2A1U	1LB5
GO Terms Enriched among Interactors		None	Tumor Necrosis Factor Receptor Binding Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Toll-like Receptor 3 Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Raft Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Bone Resorption Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Cytoplasmic Side Of Plasma Membrane Positive Regulation Of T Cell Cytokine Production Positive Regulation Of DNA-binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin Protein Ligase Binding