USP38

Description		ubiquitin specific peptidase 38
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Innate Immune Response Protein K48-linked Ubiquitination Antiviral Innate Immune Response Protein K33-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31451708) Malaria ( 31844061) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258) Severity of nausea and vomiting of pregnancy ( 29563502) Systolic blood pressure ( 27841878) Urate levels ( 31578528)
Interacting Genes		3 interacting genes: HDAC1 UBC VAV2
Entrez ID		84640
HPRD ID		15635
Ensembl ID		ENSG00000170185
Uniprot IDs		A0A804HIT0 B3KSB9 Q8NB14
PDB IDs		4RXX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Myotube Differentiation Host-mediated Suppression Of Viral Transcription Hair Follicle Placode Formation Histone Deacetylase Activity Eyelid Development In Camera-type Eye Sin3-type Complex Response To Platelet-derived Growth Factor Krueppel-associated Box Domain Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Host-mediated Suppression Of Viral Proces Protein Deacetylation Protein Decrotonylase Activity NuRD Complex Protein Lysine Deacetylase Activity Histone Decrotonylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein Lysine Delactylase Activity Core Promoter Sequence-specific DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Cell Fate Specification Positive Regulation Of Oligodendrocyte Differentiation Fungiform Papilla Formation Protein Tag Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-epsilon Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation NF-kappaB Binding Nucleosomal DNA Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Endoderm Development Host-mediated Perturbation Of Viral Transcription Anatomical Structure Formation Involved In Morphogenesis Regulation Of Androgen Receptor Signaling Pathway DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Lamellipodium Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone Deacetylase Complex Regulation Of Myotube Differentiation Oligodendrocyte Differentiation
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