UMPS and DLST

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		UMPS	DLST
Gene Name		uridine monophosphate synthetase	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Mitochondrial Matrix Membrane Oxoglutarate Dehydrogenase Complex Extracellular Vesicular Exosome
	Molecular Function	Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity	Dihydrolipoyllysine-residue Succinyltransferase Activity
	Biological Process	Pyrimidine Nucleobase Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process UMP Biosynthetic Process Female Pregnancy Lactation Cellular Response To Drug 'de Novo' UMP Biosynthetic Process Small Molecule Metabolic Process Pyrimidine Nucleoside Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle Lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Pyrimidine biosynthesis Pyrimidine metabolism Metabolism of nucleotides	Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)
Drugs
Diseases
GWAS			Non-small cell lung cancer ( 23144319)
Protein-Protein Interactions		10 interactors: A2M CALU CDC42EP3 DLST NOS3 PAXIP1 PLA2G12A PSEN1 RPS29 ZNF227	15 interactors: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UMPS ZBTB16 ZHX1
Entrez ID		7372	1743
HPRD ID		02022	00520
Ensembl ID			ENSG00000119689
Uniprot IDs		A8K5J1 B5LY70 P11172	B7Z6J1 P36957
PDB IDs		2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP
Enriched GO Terms of Interacting Partners?		Exocytosis Platelet Degranulation Cajal-Retzius Cell Differentiation Positive Regulation Of Histone H3-K36 Methylation Beta-amyloid Formation Catabolic Process Endothelial Cell Migration Intracellular Signal Transduction Blood Coagulation Hemostasis Extracellular Matrix Disassembly Epithelial Cell Migration Epithelium Migration Smooth Muscle Hyperplasia Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Complement Activation, Lectin Pathway Secretion By Cell Blood Vessel Development Cellular Amino Acid Catabolic Process Vasculature Development Cellular Nitrogen Compound Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Regulation Of Body Fluid Levels Smooth Muscle Adaptation Synaptic Vesicle Targeting Regulation Of Resting Membrane Potential Wound Healing Secretion Negative Regulation Of Muscle Hyperplasia Regulation Of Systemic Arterial Blood Pressure By Endothelin Nitrogen Compound Metabolic Process Positive Regulation Of Protein Complex Assembly Cell Activation Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Choline Transport Ameboidal-type Cell Migration Response To Wounding Platelet Activation Regulation Of Protein Ubiquitination Carboxylic Acid Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Catalytic Activity Lysine Catabolic Process Arginine Catabolic Process Chorion Development Amyloid Precursor Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Cell Migration Positive Regulation Of Guanylate Cyclase Activity
Tagcloud ?		acrofacial arch auxotrophic biallelic biosynthesis bud cad complementation dho dhodehase dhodh dihydroorotate discrepancies discrepant dysostosis exceptional genee miller mim missense novo oa orotic pharyngeal postaxial predicts pyrimidine requirement weidemann	acneiform aphtha b51 began behcet believe chorioretinopathy deteriorate eruption erythema gradual granulomas granulomatous hypopyon infliximab interstitial nephritis nodosum november occasionally prednisolone psl reportedly sarcoidosis sometimes spasmodic stated transferred uveitis
Tagcloud (Difference) ?		acrofacial arch auxotrophic biallelic biosynthesis bud cad complementation dho dhodehase dhodh dihydroorotate discrepancies discrepant dysostosis exceptional genee miller mim missense novo oa orotic pharyngeal postaxial predicts pyrimidine requirement weidemann	acneiform aphtha b51 began behcet believe chorioretinopathy deteriorate eruption erythema gradual granulomas granulomatous hypopyon infliximab interstitial nephritis nodosum november occasionally prednisolone psl reportedly sarcoidosis sometimes spasmodic stated transferred uveitis
Tagcloud (Intersection) ?