UMPS and RPS29

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		UMPS	RPS29
Description		uridine monophosphate synthetase	ribosomal protein S29
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Small Ribosomal Subunit Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Extracellular Exosome Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Ribonucleoprotein Complex
	Molecular Function	Catalytic Activity Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Lyase Activity Carboxy-lyase Activity Identical Protein Binding	Structural Constituent Of Ribosome Zinc Ion Binding Metal Ion Binding
	Biological Process	'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UMP Biosynthetic Process UDP Biosynthetic Process Pyrimidine Nucleobase Biosynthetic Process 'de Novo' UMP Biosynthetic Process	Cytoplasmic Translation Translation
Pathways		Pyrimidine biosynthesis	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		6-hydroxyuridine-5'-phosphate
Diseases		Orotic aciduria
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery disease ( 28714974 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Plateletcrit ( 32888494) Serum metabolite levels ( 33031748)	Metabolite levels ( 23823483) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Rosacea symptom severity ( 29771307) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738)
Interacting Genes		18 interacting genes: A2M CALU CASP8 CDC42EP3 DLST FOXP1 NOS3 OGT PAXIP1 PIK3CA PLA2G12A PSEN1 RAD51 RB1CC1 RPS29 SUMO2 USP7 ZNF227	9 interacting genes: ADH6 CEBPA CTBP2 ERCC6 PRMT1 SMARCD1 UBC UMPS WEE2-AS1
Entrez ID		7372	6235
HPRD ID		02022	04698
Ensembl ID		ENSG00000114491	ENSG00000213741
Uniprot IDs		A8K5J1 P11172	A0A087WTT6 P62273
PDB IDs		2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP 6YVK 6YVL 6YVM 6YVN 6YVO 6YWT 6YWU 6ZWY 6ZWZ 6ZX0 6ZX1 6ZX2 6ZX3 7AM9 7ASQ 7OQF 7OQI 7OQK 7OQM 7OQN 7OTU 7OUZ 7OV0 7Q1H	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Autophagosome Organization Autophagosome Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Vacuole Organization Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endothelial Cell Migration PML Body Negative Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Signaling Myeloid Leukocyte Differentiation Regulation Of Smooth Muscle Cell Proliferation Regulation Of TOR Signaling Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Programmed Necrotic Cell Death Organelle Assembly Rough Endoplasmic Reticulum Pyroptotic Inflammatory Response Protein-containing Complex Protein Processing Dihydrolipoyllysine-residue Succinyltransferase Activity DNA Damage Response Negative Regulation Of Core Promoter Binding Response To Glucoside Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ribophagy Cytoskeletal Regulatory Protein Binding Positive Regulation Of Gene Expression Adipose Tissue Development Positive Regulation Of Protein Metabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Signaling Cysteine-type Endopeptidase Activity	White Fat Cell Differentiation Positive Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Negative Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA Metabolic Process GATOR1 Complex Binding Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of DNA Recombination Regulation Of DNA-templated Transcription Initiation Response To Vitamin B2 C/EBP Complex Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Chromatin Binding Fat Cell Differentiation CHOP-C/EBP Complex Response To Phenylpropanoid Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Nuclear Matrix Regulation Of Hemopoiesis Response To Nutrient White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Viral Process Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress DNA Protection Transcription Elongation By RNA Polymerase I Response To Superoxide Response To Oxygen Radical Regulation Of Hemoglobin Biosynthetic Process Protein-arginine Omega-N Monomethyltransferase Activity N-methyltransferase Activity Mitogen-activated Protein Kinase P38 Binding Response To Methionine Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity
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