UMPS

Description		uridine monophosphate synthetase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Catalytic Activity Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Lyase Activity Carboxy-lyase Activity Identical Protein Binding
	Biological Process	'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UMP Biosynthetic Process UDP Biosynthetic Process Pyrimidine Nucleobase Biosynthetic Process 'de Novo' UMP Biosynthetic Process
Pathways		Pyrimidine biosynthesis
Drugs		6-hydroxyuridine-5'-phosphate
Diseases		Orotic aciduria
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery disease ( 28714974 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Plateletcrit ( 32888494) Serum metabolite levels ( 33031748)
Interacting Genes		18 interacting genes: A2M CALU CASP8 CDC42EP3 DLST FOXP1 NOS3 OGT PAXIP1 PIK3CA PLA2G12A PSEN1 RAD51 RB1CC1 RPS29 SUMO2 USP7 ZNF227
Entrez ID		7372
HPRD ID		02022
Ensembl ID		ENSG00000114491
Uniprot IDs		A8K5J1 P11172
PDB IDs		2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP 6YVK 6YVL 6YVM 6YVN 6YVO 6YWT 6YWU 6ZWY 6ZWZ 6ZX0 6ZX1 6ZX2 6ZX3 7AM9 7ASQ 7OQF 7OQI 7OQK 7OQM 7OQN 7OTU 7OUZ 7OV0 7Q1H
Enriched GO Terms of Interacting Partners?		Autophagosome Organization Autophagosome Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Vacuole Organization Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endothelial Cell Migration PML Body Negative Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Signaling Myeloid Leukocyte Differentiation Regulation Of Smooth Muscle Cell Proliferation Regulation Of TOR Signaling Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Programmed Necrotic Cell Death Organelle Assembly Rough Endoplasmic Reticulum Pyroptotic Inflammatory Response Protein-containing Complex Protein Processing Dihydrolipoyllysine-residue Succinyltransferase Activity DNA Damage Response Negative Regulation Of Core Promoter Binding Response To Glucoside Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ribophagy Cytoskeletal Regulatory Protein Binding Positive Regulation Of Gene Expression Adipose Tissue Development Positive Regulation Of Protein Metabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Signaling Cysteine-type Endopeptidase Activity
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