ENO2 and SIGIRR

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ENO2	SIGIRR
Description		enolase 2	single Ig and TIR domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell Cortex Cell Surface Membrane Growth Cone Neuronal Cell Body Perikaryon Membrane Raft Extracellular Exosome Synaptic Membrane	Plasma Membrane Cell Surface Membrane
	Molecular Function	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Enzyme Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding	Protein Binding
	Biological Process	Gluconeogenesis Glycolytic Process Response To Xenobiotic Stimulus Response To Estradiol Canonical Glycolysis	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Glycolysis Gluconeogenesis	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling
Drugs		2-Phosphoglycolic Acid
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Lymphocyte count ( 32888494)
Interacting Genes		27 interacting genes: A2M ACD AKT1 ANXA11 BMERB1 C6orf47 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 MTNR1A NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C UBE3A USP2-AS1	9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6
Entrez ID		2026	59307
HPRD ID		00573	12018
Ensembl ID		ENSG00000111674	ENSG00000185187
Uniprot IDs		P09104 Q6FHV6	C9JFX4 H0YDF8 H0YDR5 Q6IA17
PDB IDs		1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ 5TD9 5TIJ 7MBH
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Translation Elongation Factor Binding Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Negative Regulation Of Cellular Component Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Positive Regulation Of Chromosome Organization Maintenance Of Protein Location In Mitochondrion Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomere Organization Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Organelle Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Regulation Of DNA Metabolic Process Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Establishment Of Protein Localization To Organelle Organelle Organization DNA Biosynthetic Process Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cilium Assembly Cell Division Microtubule Cytoskeleton Ubiquitin-like Protein Ligase Binding Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Mitotic Cell Cycle Regulation Of TRNA Methylation	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of Innate Immune Response Regulation Of Cytokine Production Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Activation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Response To Interleukin-1 Positive Regulation Of Immune System Process Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Innate Immune Response Response To Lipopolysaccharide Positive Regulation Of Innate Immune Response Immune Response Regulation Of Type II Interferon Production Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Interleukin-1-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Regulation Of Cytokine Production Involved In Immune Response Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Immune Response-activating Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Defense Response Regulation Of JNK Cascade Response To Lipid Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Lipopolysaccharide-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response
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