UHRF1 and HIST1H2BB

Number of citations of the paper that reports this interaction (PMID 14993289)
51

Data Source:
HPRD (in vitro, in vivo)

		UHRF1	HIST1H2BB
Gene Name		ubiquitin-like with PHD and ring finger domains 1	histone cluster 1, H2bb
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Euchromatin Heterochromatin Nucleus Replication Fork Nuclear Matrix	Nucleosome Nucleus Nucleoplasm
	Molecular Function	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Ligase Activity Nucleosomal Histone Binding Methylated Histone Binding Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Transcription, DNA-templated Cell Cycle Cell Proliferation Maintenance Of DNA Methylation Histone Monoubiquitination Gene Expression Histone Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Chromatin Organization Nucleosome Assembly
Pathways		Epigenetic regulation of gene expression DNA methylation	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: BTRC DNMT1 DNMT3A H3F3A H3F3B HIST1H2AB HIST1H2BB HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST3H3 KAT5 MBD4 PARP1 PRKACA	12 interactors: APP CDK1 CDK2 CREBBP DYRK1A EID1 EP300 ERCC6 KAT2B RNF20 UHRF1 USP16
Entrez ID		29128	3018
HPRD ID		06992	07536
Ensembl ID			ENSG00000196226
Uniprot IDs		Q96T88	P33778
PDB IDs		2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA DNA Modification Chromatin Silencing DNA Methylation Negative Regulation Of Gene Expression, Epigenetic Gene Silencing Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Methylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated DNA Replication-dependent Nucleosome Assembly Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleosome Assembly Chromosome Organization Negative Regulation Of Gene Expression Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Organization Protein-DNA Complex Assembly DNA Packaging Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Regulation Of Body Fluid Levels DNA Conformation Change Wound Healing Regulation Of Gene Silencing Response To Wounding Gene Expression Cellular Macromolecular Complex Assembly Organelle Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Complex Assembly Nitrogen Compound Metabolic Process Response To Stress Regulation Of Gene Expression Cellular Component Assembly Regulation Of Metabolic Process	Histone Modification Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Positive Regulation Of Gene Expression N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Chromatin Organization Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process N-terminal Protein Amino Acid Acetylation Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process N-terminal Protein Amino Acid Modification Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Protein Metabolic Process Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Protein Catabolic Process Rhythmic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Mitotic Cell Cycle Histone Acetylation G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation
Tagcloud ?		24hrs acetyl acetylated aptx caco cdkn1a characterised cyanotoxin cylindrospermopsin cyn dimethylated ehmt2 emerging h2a highlighted histones initiating kat5 lys4 lys5 methyltransferases modifying myst1 nucleosomal pms2 recognised recombination remodelling transcriptomic
Tagcloud (Difference) ?		24hrs acetyl acetylated aptx caco cdkn1a characterised cyanotoxin cylindrospermopsin cyn dimethylated ehmt2 emerging h2a highlighted histones initiating kat5 lys4 lys5 methyltransferases modifying myst1 nucleosomal pms2 recognised recombination remodelling transcriptomic
Tagcloud (Intersection) ?