UHRF1 and PCNA

Number of citations of the paper that reports this interaction (PubMedID 30357346)
48

Data Source:
BioGRID (enzymatic study)

		UHRF1	PCNA
Description		ubiquitin like with PHD and ring finger domains 1	proliferating cell nuclear antigen
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Spindle Nuclear Matrix	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Chromatin Male Germ Cell Nucleus Nucleus Nuclear Lamina Nucleoplasm Replication Fork Centrosome Nuclear Body Replisome Nuclear Replication Fork PCNA Complex Extracellular Exosome PCNA-p21 Complex
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Transferase Activity Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K9me2/3 Reader Activity DNA Damage Sensor Activity Histone H3 Ubiquitin Ligase Activity	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Binding Chromatin Binding Damaged DNA Binding Protein Binding Enzyme Binding Nuclear Estrogen Receptor Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Histone Acetyltransferase Binding Identical Protein Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Response To Stress DNA Damage Response Protein Ubiquitination Heterochromatin Formation Homologous Recombination Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Protein Autoubiquitination Mitotic Spindle Assembly	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Leading Strand Elongation Regulation Of DNA Replication DNA Repair Base-excision Repair, Gap-filling Mismatch Repair Chromatin Organization DNA Damage Response Response To Oxidative Stress Heart Development Translesion Synthesis Epithelial Cell Differentiation Replication Fork Processing Positive Regulation Of Deoxyribonuclease Activity Response To Estradiol Response To Lipid Cellular Response To UV Estrous Cycle Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Response To Cadmium Ion Cellular Response To Hydrogen Peroxide Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Liver Regeneration Positive Regulation Of DNA-directed DNA Polymerase Activity Response To L-glutamate Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways		DNA methylation Chromatin modifications during the maternal to zygotic transition (MZT)	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Transcription of E2F targets under negative control by DREAM complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand SUMOylation of DNA replication proteins Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription E3 ubiquitin ligases ubiquitinate target proteins
Drugs			Liothyronine Acetylsalicylic acid
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		36 interacting genes: AKT1 ATR DNMT3A ERCC1 ERG FANCD2 FZR1 H2AC4 H2BC3 H3-3A H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 KIF11 LASP1 LIG1 MBD4 MUS81 NR3C1 PCLAF PCNA PLK1 PRKACA SAP30 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UHRF2 USP7	142 interacting genes: ALDOA APEX1 APEX2 ATAD5 ATM BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 CMTM5 CREBBP DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 ERCC6 ERRFI1 ESCO2 EXO1 FAN1 FANCD2 FANCL FBH1 FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HUS1 ING1 KCTD13 KMT5A LDHA LIG1 MCL1 MGMT MLH1 MLH3 MSH2 MSH3 MSH6 MTOR MUTYH MYBBP1A NEDD8 NIPBL NMRAL1 NSD2 NTHL1 NUTF2 PARP1 PARP10 PARPBP PCLAF PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLK POLL POLM PPP1CA PRKDC PTEN PTMA RAD18 RAD9A RBBP8 RECQL5 RFC1 RFC2 RFC3 RFC4 RFC5 RFWD3 RPA1 S100A8 SDE2 SEC23IP SIVA1 SLC30A8 SMARCAD1 SPG21 SUB1 SUMO1 TCOF1 TDG TIRAP TMEM218 TPI1 UBB UBC UBE2A UBE2B UBE2D3 UBE2I UBE3D UHRF1 UNG USP4 WDR48 WRN XPA XRCC1 XRCC5 XRCC6 YBX1 ZBTB1
Entrez ID		29128	5111
HPRD ID		06992	01456
Ensembl ID		ENSG00000276043	ENSG00000132646
Uniprot IDs		A0A087WVR3 Q96T88	P12004
PDB IDs		2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED 6VYJ 6W92 7FB7 8JIG 8WMS 8XV4 8XV6 8XV7 8XV8	1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3JA9 3P87 3TBL 3VKX 3WGW 4D2G 4RJF 4ZTD 5E0T 5E0U 5E0V 5IY4 5MAV 5MLO 5MLW 5MOM 5YCO 5YD8 6CBI 6EHT 6FCM 6FCN 6GIS 6GWS 6HVO 6K3A 6QC0 6QCG 6S1M 6S1N 6S1O 6TNY 6TNZ 6VVO 7EFA 7KQ0 7KQ1 7M5L 7M5M 7M5N 7NV0 7NV1 7QNZ 7QO1 8B8T 8COB 8E84 8F5Q 8GCJ 8GL9 8GLA 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8YJH 8YJL 8YJQ 8YJR 8YJS 8YJU 8YJV 8YJW 8YJZ 9B8S 9B8T 9CG4 9CHM 9CL7 9CMA 9EOA 9F6D 9F6E 9F6F 9GY0
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Repair Nucleosome Chromosome Structural Constituent Of Chromatin Chromatin Organization Chromatin Remodeling DNA Metabolic Process DNA Damage Response DNA Binding Nucleosome Assembly Nucleosome Organization Cellular Response To Stress Chromosome Organization Protein Heterodimerization Activity Chromosome, Telomeric Region Protein-DNA Complex Assembly Macromolecule Metabolic Process Telomere Organization Negative Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process TORC1 Signaling Response To Radiation Negative Regulation Of TORC1 Signaling Protein-containing Complex Mitotic DNA Damage Checkpoint Signaling Protein Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Mitotic DNA Integrity Checkpoint Signaling Chromatin Binding Response To Ionizing Radiation Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Ubiquitin Conjugating Enzyme Activity Response To UV TOR Signaling Cellular Response To Nutrient Levels Regulation Of Cell Cycle Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Stress Negative Regulation Of TOR Signaling	DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Nucleus Nucleoplasm Response To Stress DNA Replication DNA Recombination Macromolecule Metabolic Process Damaged DNA Binding Double-strand Break Repair DNA Biosynthetic Process Regulation Of DNA Metabolic Process Response To Radiation DNA Binding Postreplication Repair Response To UV Positive Regulation Of DNA Metabolic Process DNA Synthesis Involved In DNA Repair Recombinational Repair Base-excision Repair Chromosome Organization DNA-templated DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Mismatch Repair DNA-directed DNA Polymerase Activity Response To Light Stimulus Translesion Synthesis Somatic Hypermutation Of Immunoglobulin Genes Regulation Of DNA Recombination Negative Regulation Of Metabolic Process DNA Clamp Loader Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Somatic Diversification Of Immunoglobulins Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of DNA Metabolic Process DNA Polymerase Activity Somatic Cell DNA Recombination Ctf18 RFC-like Complex Glycolytic Process
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