UBE2B and UBA1

Number of citations of the paper that reports this interaction (PubMedID 36162503)
114

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down)

		UBE2B	UBA1
Description		ubiquitin conjugating enzyme E2 B	ubiquitin like modifier activating enzyme 1
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GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane Membrane HULC Complex	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Nucleotide Binding RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spermatogenesis Sperm Axoneme Assembly Response To Xenobiotic Stimulus Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Ectopic Germ Cell Programmed Cell Death Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Negative Regulation Of Developmental Process Protein Autoubiquitination Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Reproductive Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination
Pathways		Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Hexatantalum Dodecabromide Quercetin
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Relative amplitude of rest-activity cycles ( 30120083)
Interacting Genes		29 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 H2AC20 H2BC1 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF167 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBA6 UBR1 UBR2 UBR3 UBR4 UBR5 UNC119	51 interacting genes: ABCF1 AZGP1P2 BUB3 CDK1 CEBPA CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2
Entrez ID		7320	7317
HPRD ID		01533	02440
Ensembl ID		ENSG00000119048	ENSG00000130985
Uniprot IDs		P63146	A0A024R1A3 P22314
PDB IDs		1JAS 2Y4W 2YB6 2YBF	4P22 6DC6 7PYV
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteolysis Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Zinc Ion Binding Transferase Activity Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein K29-linked Ubiquitination Metal Ion Binding Cellular Response To Stress Protein Autoubiquitination Protein K63-linked Ubiquitination Ubiquitin Activating Enzyme Activity Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Ubiquitin Protein Ligase Binding Protein K6-linked Ubiquitination Response To Stress Cytoplasm Protein Quality Control Protein-containing Complex Binding HULC Complex DNA Damage Response Response To Amino Acid Positive Regulation Of Metabolic Process Placenta Development L-leucine Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Epithelial Cell Proliferation Involved In Prostate Gland Development Limb Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Ubiquitin-like Modifier Activating Enzyme Activity T Follicular Helper Cell Differentiation	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein Modification Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Ubiquitin-dependent Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Nucleoplasm ISG15 Transferase Activity HULC Complex DNA Damage Response ISG15-protein Conjugation Regulation Of Post-translational Protein Modification Free Ubiquitin Chain Polymerization Nucleus DNA Repair Positive Regulation Of Post-translational Protein Modification Protein K29-linked Ubiquitination Cellular Response To Stress Cell Cycle Phase Transition Ubiquitin Binding Regulation Of Protein Modification Process Protein K27-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination TORC1 Signaling DNA Metabolic Process
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