UBE2B and UBR3

Number of citations of the paper that reports this interaction (PubMedID 25582440)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		UBE2B	UBR3
Description		ubiquitin conjugating enzyme E2 B	ubiquitin protein ligase E3 component n-recognin 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane Membrane HULC Complex	Ubiquitin Ligase Complex Cytoplasm Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spermatogenesis Sperm Axoneme Assembly Response To Xenobiotic Stimulus Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Ectopic Germ Cell Programmed Cell Death Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Negative Regulation Of Developmental Process Protein Autoubiquitination Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Reproductive Process	In Utero Embryonic Development Suckling Behavior Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Smell Embryo Development Ending In Birth Or Egg Hatching Protein Ubiquitination Olfactory Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Relative amplitude of rest-activity cycles ( 30120083)	Longitudinal change in brain amyloid plaque burden ( 26268530) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Urate levels in obese individuals ( 25811787)
Interacting Genes		29 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 H2AC20 H2BC1 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF167 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBA6 UBR1 UBR2 UBR3 UBR4 UBR5 UNC119	7 interacting genes: APEX1 DZIP3 MAGEC2 UBE2A UBE2B UBE2D2 UBE2H
Entrez ID		7320	130507
HPRD ID		01533	15887
Ensembl ID		ENSG00000119048	ENSG00000144357
Uniprot IDs		P63146	Q6ZT12
PDB IDs		1JAS 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteolysis Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Zinc Ion Binding Transferase Activity Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Protein K29-linked Ubiquitination Metal Ion Binding Cellular Response To Stress Protein Autoubiquitination Protein K63-linked Ubiquitination Ubiquitin Activating Enzyme Activity Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Ubiquitin Protein Ligase Binding Protein K6-linked Ubiquitination Response To Stress Cytoplasm Protein Quality Control Protein-containing Complex Binding HULC Complex DNA Damage Response Response To Amino Acid Positive Regulation Of Metabolic Process Placenta Development L-leucine Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Epithelial Cell Proliferation Involved In Prostate Gland Development Limb Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Ubiquitin-like Modifier Activating Enzyme Activity T Follicular Helper Cell Differentiation	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Macromolecule Catabolic Process HULC Complex Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Postreplication Repair Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification Process Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Transferase Activity Protein Autoubiquitination Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA-(abasic Site) Binding Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity Macromolecule Metabolic Process Positive Regulation Of Reciprocal Meiotic Recombination Proteasomal Protein Catabolic Process Proteolysis DNA Repair Uracil DNA N-glycosylase Activity Phosphodiesterase I Activity ATP Binding Response To UV Double-stranded DNA 3'-5' DNA Exonuclease Activity Chiasma Assembly RNA-DNA Hybrid Ribonuclease Activity BBSome DNA Metabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Double-stranded Telomeric DNA Binding Telomere Localization DNA Damage Response 3'-5'-DNA Exonuclease Activity Nucleotide Binding
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