C8A and SLC10A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C8A	SLC10A1
Description		complement C8 alpha chain	solute carrier family 10 member 1
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Complement Binding Protein Binding Protein-containing Complex Binding	Virus Receptor Activity Protein Binding Bile Acid:sodium Symporter Activity Bile Acid Transmembrane Transporter Activity Symporter Activity
	Biological Process	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway	Monoatomic Ion Transport Sodium Ion Transport Lipid Transport Bile Acid And Bile Salt Transport Response To Nutrient Levels Response To Estrogen Response To Ethanol Symbiont Entry Into Host Cell Transmembrane Transport Cellular Response To Xenobiotic Stimulus
Pathways		Terminal pathway of complement Regulation of Complement cascade	Recycling of bile acids and salts
Drugs		Zinc Zinc acetate	Bulevirtide
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS			Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483) Triglyceride levels ( 30108155)
Interacting Genes		9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1	115 interacting genes: ABHD16A ACSL5 AGPAT3 APOL3 ARL6IP6 ASGR1 ATP13A1 ATP6V0B BMP10 BTN2A2 C2 C3orf52 C8A CDIPT CFHR5 CFTR CLDN19 CMTM3 COX20 CXCL9 CYB5B CYB5R3 DERL1 DGAT2L6 EMC6 EMD FA2H FAM241B FAXDC2 FCER1G FDFT1 FKBP8 FXYD3 FXYD6 FXYD6-FXYD2 GAST GDE1 GIMAP5 GOSR2 GPR151 GPR152 IFITM2 IFITM3 IFTAP INSIG2 LNPEP LRP10 LSS MAL MALL MFSD6 MS4A1 MYADML2 NEU1 NINJ2 NKG7 ORMDL1 ORMDL2 ORMDL3 OTOP3 PEDS1-UBE2V1 PEX16 PKMYT1 PMP22 RABAC1 RTP2 RUSF1 SACM1L SCAMP4 SEC22A SELENOK SERP1 SFT2D1 SFT2D2 SFXN1 SLC12A7 SLC16A13 SLC25A46 SLC29A2 SLC35E4 SLC38A1 SLC38A7 SLC41A1 SLC66A2 SLC7A3 SMPD2 STATH STX12 STX7 TAP1 TFRC TMBIM1 TMEM119 TMEM120B TMEM121 TMEM147 TMEM222 TMEM234 TMEM239 TMEM242 TMEM60 TMEM97 TMUB2 TOMM6 TRARG1 TSPO2 TVP23B UBIAD1 UNC50 UPK1B VAMP3 VAPB YIF1A YIPF4 YIPF6
Entrez ID		731	6554
HPRD ID		00409	01672
Ensembl ID		ENSG00000157131	ENSG00000100652
Uniprot IDs		P07357	B2RA41 Q14973
PDB IDs		2QOS 2QQH 2RD7 3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H	7FCI 7PQG 7PQQ 7VAD 7VAG 7WSI 7ZYI 8HRX 8HRY 8RQF
Enriched GO Terms of Interacting Partners?		Membrane Attack Complex Other Organism Cell Membrane Complement Activation Complement Activation, GZMK Pathway Transmembrane Transporter Complex Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Humoral Immune Response Immune Effector Process Killing Of Cells Of Another Organism Activation Of Immune Response Positive Regulation Of Immune System Process Cell Killing Plasma Membrane Positive Regulation Of Immune Response Membrane Regulation Of Immune System Process Virus Receptor Activity Regulation Of Immune Response Lysine Transport L-histidine Import Across Plasma Membrane Cobalt Ion Transmembrane Transporter Activity Negative Regulation Of Activation Of Membrane Attack Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity Blood Microparticle Symbiont Entry Into Host Cell Ornithine Transport L-arginine Import Across Plasma Membrane Immune Response Negative Regulation Of Complement-dependent Cytotoxicity L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Bile Acid:sodium Symporter Activity L-lysine Transmembrane Transport Biological Process Involved In Interaction With Host Ferrous Iron Transmembrane Transporter Activity Innate Immune Response Golgi Membrane Complement Binding Inorganic Cation Transmembrane Transporter Activity Cobalt Ion Transport Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity EMC Complex Aromatic Amino Acid Transport Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Defense Response To Symbiont	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Protein Binding Endomembrane System Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Negative Regulation Of Sphingolipid Biosynthetic Process Membrane Organization Serine Palmitoyltransferase Complex Establishment Of Protein Localization To Membrane Establishment Of Protein Localization Cellular Localization Plasma Membrane Steroid Biosynthetic Process Vesicle-mediated Transport Lipid Metabolic Process Membrane Docking Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Ceramide Metabolic Process Myelination Axon Ensheathment Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Golgi Membrane Protein Insertion Into Membrane Protein Transport Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Nitric-oxide Synthase Complex Transmembrane Transport Organelle Localization By Membrane Tethering Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Lysosomal Membrane Sterol Metabolic Process SNARE Complex Organelle Fusion Sphingomyelin Metabolic Process Amino Acid Transmembrane Transport Regulation Of Membrane Lipid Metabolic Process Nuclear Inner Membrane Phospholipid Metabolic Process Nitrite Reductase (NO-forming) Activity
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