C8A and C8B

Number of citations: 0 (PubMedID 10387094)
Data Source: HPRD (in vitro, in vivo)

		C8A	C8B
Name		complement C8 alpha chain	complement C8 beta chain
Structure
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex Extracellular Vesicle
	Molecular Function	Complement Binding Protein Binding Protein-containing Complex Binding	Protein-containing Complex Binding
	Biological Process	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways		Terminal pathway of complement Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Zinc Zinc acetate	Zinc Copper Zinc acetate
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		No GWAS studies recorded	Logical memory (delayed recall) in normal cognition ( 29274321 )
Interacting Genes		9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1	3 interacting genes: C5 C8A CLU
Entrez ID		731	732
HPRD ID		00409	00410
Ensembl ID		ENSG00000157131	ENSG00000021852
Uniprot IDs		P07357	A0A8Q3WL56 B7Z550 B7Z555 P07358
PDB IDs		2QOS 2QQH 2RD7 3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H	3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H
GO Terms Enriched among Interactors		Membrane Attack Complex Other Organism Cell Membrane Complement Activation Complement Activation, GZMK Pathway Transmembrane Transporter Complex Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Humoral Immune Response Immune Effector Process Killing Of Cells Of Another Organism Activation Of Immune Response Positive Regulation Of Immune System Process Cell Killing Plasma Membrane Positive Regulation Of Immune Response Membrane Regulation Of Immune System Process Virus Receptor Activity Regulation Of Immune Response Lysine Transport L-histidine Import Across Plasma Membrane Cobalt Ion Transmembrane Transporter Activity Negative Regulation Of Activation Of Membrane Attack Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity Blood Microparticle Symbiont Entry Into Host Cell Ornithine Transport L-arginine Import Across Plasma Membrane Immune Response Negative Regulation Of Complement-dependent Cytotoxicity L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Bile Acid:sodium Symporter Activity L-lysine Transmembrane Transport Biological Process Involved In Interaction With Host Ferrous Iron Transmembrane Transporter Activity Innate Immune Response Golgi Membrane Complement Binding Inorganic Cation Transmembrane Transporter Activity Cobalt Ion Transport Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity EMC Complex Aromatic Amino Acid Transport Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Defense Response To Symbiont	Complement Activation, Classical Pathway Complement Activation Other Organism Cell Membrane Membrane Attack Complex Transmembrane Transporter Complex Complement Activation, GZMK Pathway Complement Activation, Alternative Pathway Humoral Immune Response Immune Effector Process Activation Of Immune Response Innate Immune Response Positive Regulation Of Immune Response Defense Response To Other Organism Defense Response To Symbiont Regulation Of Immune Response Receptor Ligand Activity Killing Of Cells Of Another Organism Blood Microparticle Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Positive Regulation Of Immune System Process Response To Other Organism Immune Response Cell Killing Positive Regulation Of Neurofibrillary Tangle Assembly Response To External Biotic Stimulus Defense Response Negative Regulation Of Activation Of Membrane Attack Complex Central Nervous System Myelin Maintenance Immune Complex Clearance Extracellular Space Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Regulation Of Immune System Process Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Complement-dependent Cytotoxicity Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Macrophage Chemotaxis Complement Binding Protein Import Protein-containing Complex Binding Immune System Process Spherical High-density Lipoprotein Particle Signaling Receptor Binding Microglial Cell Proliferation Extracellular Exosome Protein Carrier Chaperone Extracellular Region