C8A and CD59

Number of citations of the paper that reports this interaction (PMID 7544344)
7

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		C8A	CD59
Gene Name		complement component 8, alpha polypeptide	CD59 molecule, complement regulatory protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Membrane Anchored Component Of External Side Of Plasma Membrane Vesicle Sarcolemma Compact Myelin Extracellular Vesicular Exosome
	Molecular Function	Complement Binding Protein Complex Binding	Complement Binding Protein Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response	Cell Activation Negative Regulation Of Activation Of Membrane Attack Complex Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Innate Immune Response
Pathways		Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: C8B C8G C9 CD59	12 interactors: C8A C9 CD2 CD8A CD9 EGFR GNAI3 NCR1 NCR3 SLC6A8 SMAD4 SRC
Entrez ID		731	966
HPRD ID		00409	00117
Ensembl ID		ENSG00000157131
Uniprot IDs		P07357	E9PI80 P13987 Q6FHM9
PDB IDs		2QOS 2QQH 2RD7 3OJY	1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK
Enriched GO Terms of Interacting Partners?		Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation, Alternative Pathway Cytolysis Regulation Of Inflammatory Response Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Innate Immune Response Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Immune Response Positive Regulation Of Immune System Process Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Immune Response Regulation Of Immune System Process Defense Response Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Immune Response Negative Regulation Of Activation Of Membrane Attack Complex Response To Stress Hemolysis By Symbiont Of Host Erythrocytes Negative Regulation Of Complement Activation Killing Of Cells Of Other Organism Regulation Of Metabolic Process Positive Regulation Of T Cell Proliferation Response To Stimulus Interaction With Host Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune Response Regulation Of T Cell Proliferation	Cell Activation Response To Stress Regulation Of Immune System Process Regulation Of Immune Response Defense Response Immune System Process Complement Activation, Alternative Pathway Positive Regulation Of Protein Transport Immune Response Membrane Organization Blood Coagulation Hemostasis Positive Regulation Of Immune System Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Cytolysis Single Organismal Cell-cell Adhesion Platelet Activation Regulation Of Complement Activation Regulation Of Body Fluid Levels Wound Healing Cell Adhesion Regulation Of Protein Transport Positive Regulation Of Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Establishment Of Protein Localization Leukocyte Mediated Immunity Adaptive Immune Response Response To Wounding Regulation Of Humoral Immune Response Regulation Of Inflammatory Response Positive Regulation Of Transport Natural Killer Cell Activation Regulation Of Protein Localization Movement Of Cell Or Subcellular Component Innate Immune Response Alkanesulfonate Metabolic Process Cytotoxic T Cell Differentiation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Myeloid Dendritic Cell Activation Regulation Of Acute Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Positive Regulation Of Cytokine Secretion Regulation Of Protein Processing Positive Regulation Of Protein Import Into Nucleus Lymphocyte Activation
Tagcloud ?			activation attack axotomy cause clusterin complement contribute death degeneration facial following homologous hybridization immunocytochemistry intracranial massive motor nerve neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ transection
Tagcloud (Difference) ?			activation attack axotomy cause clusterin complement contribute death degeneration facial following homologous hybridization immunocytochemistry intracranial massive motor nerve neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ transection
Tagcloud (Intersection) ?