C8A and GOLT1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C8A	GOLT1A
Description		complement C8 alpha chain	golgi transport 1A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex	Golgi Cis Cisterna Golgi Membrane Nuclear Envelope Cytoplasm Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Endomembrane System Membrane
	Molecular Function	Complement Binding Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi
Pathways		Terminal pathway of complement Regulation of Complement cascade
Drugs		Zinc Zinc acetate
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS			Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1	26 interacting genes: ABHD16A AGPAT3 AQP6 C8A CCDC167 CLDND2 COX20 CPT1B FAXDC2 GPR152 GYPA HSD17B11 MGLL MSMO1 NAT8 NDUFA3 NRM OTULINL PLLP RNF24 SLC30A2 SLC35H1 TECR TIMM23 TMEM242 UBE2J1
Entrez ID		731	127845
HPRD ID		00409	13465
Ensembl ID		ENSG00000157131	ENSG00000174567
Uniprot IDs		P07357	Q6ZVE7
PDB IDs		2QOS 2QQH 2RD7 3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H
Enriched GO Terms of Interacting Partners?		Membrane Attack Complex Other Organism Cell Membrane Complement Activation Complement Activation, GZMK Pathway Transmembrane Transporter Complex Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Humoral Immune Response Immune Effector Process Killing Of Cells Of Another Organism Activation Of Immune Response Positive Regulation Of Immune System Process Cell Killing Plasma Membrane Positive Regulation Of Immune Response Membrane Regulation Of Immune System Process Virus Receptor Activity Regulation Of Immune Response Lysine Transport L-histidine Import Across Plasma Membrane Cobalt Ion Transmembrane Transporter Activity Negative Regulation Of Activation Of Membrane Attack Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity Blood Microparticle Symbiont Entry Into Host Cell Ornithine Transport L-arginine Import Across Plasma Membrane Immune Response Negative Regulation Of Complement-dependent Cytotoxicity L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Bile Acid:sodium Symporter Activity L-lysine Transmembrane Transport Biological Process Involved In Interaction With Host Ferrous Iron Transmembrane Transporter Activity Innate Immune Response Golgi Membrane Complement Binding Inorganic Cation Transmembrane Transporter Activity Cobalt Ion Transport Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity EMC Complex Aromatic Amino Acid Transport Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Defense Response To Symbiont	Membrane C-4 Methylsterol Oxidase Activity Monoacylglycerol Catabolic Process Lipid Metabolic Process Lipid Biosynthetic Process Endoplasmic Reticulum Membrane Monoacylglycerol Lipase Activity Steroid Biosynthetic Process Mitochondrial Inner Membrane Phosphatidylcholine Lysophospholipase Activity Lipid Catabolic Process Acylglycerol Catabolic Process Fatty Acid Metabolic Process Nitrate Transmembrane Transporter Activity Acyltransferase Activity Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle L-cysteine-S-conjugate N-acetyltransferase Activity Protein Binding Modified Amino Acid Metabolic Process Sterol Biosynthetic Process
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