C8A and MMGT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C8A	MMGT1
Description		complement C8 alpha chain	membrane magnesium transporter 1
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex	Golgi Membrane Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Early Endosome Membrane EMC Complex
	Molecular Function	Complement Binding Protein Binding Protein-containing Complex Binding	Protein Binding Cobalt Ion Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Magnesium Ion Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity Membrane Insertase Activity
	Biological Process	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway	Monoatomic Cation Transport Cobalt Ion Transport Copper Ion Transport Iron Ion Transport Magnesium Ion Transport Iron Ion Transmembrane Transport Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane Magnesium Ion Transmembrane Transport
Pathways		Terminal pathway of complement Regulation of Complement cascade	Miscellaneous transport and binding events
Drugs		Zinc Zinc acetate
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS
Interacting Genes		9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1	50 interacting genes: ADGRE2 AGR3 ANKRD46 APP ARLN C5 C8A DEFB127 EMD FIS1 FXYD6 GPR25 GRM2 INSIG2 ITGAM LNPEP MFF MS4A13 NINJ2 ORMDL2 PEX16 PLPP6 RUSF1 SEC22B SLC33A2 SLC35B4 SLC35E4 SLC38A7 SLC61A1 SLC7A14 STX12 STX1A STX1B STX3 STX6 STX8 TAS2R19 TECR THBD TMBIM6 TMED8 TMEM14A TMEM14C TMEM229B TMEM254 TMEM42 TMEM60 TMEM86B VRK2 YIF1A
Entrez ID		731	93380
HPRD ID		00409	06626
Ensembl ID		ENSG00000157131	ENSG00000169446
Uniprot IDs		P07357	Q8N4V1
PDB IDs		2QOS 2QQH 2RD7 3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H	6WW7 6Z3W 7ADO 7ADP 8EOI 8J0N 8J0O 8S9S 9C7V
Enriched GO Terms of Interacting Partners?		Membrane Attack Complex Other Organism Cell Membrane Complement Activation Complement Activation, GZMK Pathway Transmembrane Transporter Complex Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Humoral Immune Response Immune Effector Process Killing Of Cells Of Another Organism Activation Of Immune Response Positive Regulation Of Immune System Process Cell Killing Plasma Membrane Positive Regulation Of Immune Response Membrane Regulation Of Immune System Process Virus Receptor Activity Regulation Of Immune Response Lysine Transport L-histidine Import Across Plasma Membrane Cobalt Ion Transmembrane Transporter Activity Negative Regulation Of Activation Of Membrane Attack Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity Blood Microparticle Symbiont Entry Into Host Cell Ornithine Transport L-arginine Import Across Plasma Membrane Immune Response Negative Regulation Of Complement-dependent Cytotoxicity L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Bile Acid:sodium Symporter Activity L-lysine Transmembrane Transport Biological Process Involved In Interaction With Host Ferrous Iron Transmembrane Transporter Activity Innate Immune Response Golgi Membrane Complement Binding Inorganic Cation Transmembrane Transporter Activity Cobalt Ion Transport Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity EMC Complex Aromatic Amino Acid Transport Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Defense Response To Symbiont	Membrane SNAP Receptor Activity SNARE Complex Membrane Docking Vesicle Docking SNARE Binding Organelle Localization By Membrane Tethering Membrane Fusion Vesicle Fusion Organelle Membrane Fusion Endoplasmic Reticulum Organelle Fusion Protein Binding Endoplasmic Reticulum Membrane Endomembrane System Membrane Organization Intracellular Transport Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Spontaneous Synaptic Transmission Intracellular Protein Transport Other Organism Cell Membrane Membrane Attack Complex Chloride Channel Inhibitor Activity Establishment Of Protein Localization Vesicle Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Vesicle Priming Peroxisome Fission Complement Activation, GZMK Pathway Synaptic Vesicle Docking Astrocyte Projection Transmembrane Transporter Complex Recycling Endosome Mitochondrial Fission Macrophage Activation Positive Regulation Of Synaptic Transmission Complement Activation, Alternative Pathway Protein Transport Cellular Localization Establishment Of Localization In Cell
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