SLC10A1 and C2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC10A1	C2
Description		solute carrier family 10 member 1	complement C2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Cell Surface Extracellular Exosome Symbiont Cell Surface
	Molecular Function	Virus Receptor Activity Protein Binding Bile Acid:sodium Symporter Activity Bile Acid Transmembrane Transporter Activity Symporter Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Lipid Transport Bile Acid And Bile Salt Transport Response To Nutrient Levels Response To Estrogen Response To Ethanol Symbiont Entry Into Host Cell Transmembrane Transport Cellular Response To Xenobiotic Stimulus	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Opsonization Response To Bacterium Killing Of Cells Of Another Organism Response To Lipopolysaccharide Innate Immune Response Protein Maturation Response To Thyroid Hormone Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance
Pathways		Recycling of bile acids and salts	Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade
Drugs		Bulevirtide
Diseases			Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483) Triglyceride levels ( 30108155)	A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Age at first sexual intercourse ( 34211149) Age-related macular degeneration ( 20385826 23455636 20385819 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Circulating myeloperoxidase levels (serum) ( 23620142) Clostridioides difficle infection ( 33841421) Coffee consumption ( 31046077) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Endometriosis ( 28881265) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Femur bone mineral density x serum urate levels interaction ( 34046847) Hepatocellular carcinoma ( 21105107) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Platelet aggregation ( 29185836) Prostate cancer ( 23535732) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		115 interacting genes: ABHD16A ACSL5 AGPAT3 APOL3 ARL6IP6 ASGR1 ATP13A1 ATP6V0B BMP10 BTN2A2 C2 C3orf52 C8A CDIPT CFHR5 CFTR CLDN19 CMTM3 COX20 CXCL9 CYB5B CYB5R3 DERL1 DGAT2L6 EMC6 EMD FA2H FAM241B FAXDC2 FCER1G FDFT1 FKBP8 FXYD3 FXYD6 FXYD6-FXYD2 GAST GDE1 GIMAP5 GOSR2 GPR151 GPR152 IFITM2 IFITM3 IFTAP INSIG2 LNPEP LRP10 LSS MAL MALL MFSD6 MS4A1 MYADML2 NEU1 NINJ2 NKG7 ORMDL1 ORMDL2 ORMDL3 OTOP3 PEDS1-UBE2V1 PEX16 PKMYT1 PMP22 RABAC1 RTP2 RUSF1 SACM1L SCAMP4 SEC22A SELENOK SERP1 SFT2D1 SFT2D2 SFXN1 SLC12A7 SLC16A13 SLC25A46 SLC29A2 SLC35E4 SLC38A1 SLC38A7 SLC41A1 SLC66A2 SLC7A3 SMPD2 STATH STX12 STX7 TAP1 TFRC TMBIM1 TMEM119 TMEM120B TMEM121 TMEM147 TMEM222 TMEM234 TMEM239 TMEM242 TMEM60 TMEM97 TMUB2 TOMM6 TRARG1 TSPO2 TVP23B UBIAD1 UNC50 UPK1B VAMP3 VAPB YIF1A YIPF4 YIPF6	14 interacting genes: C3 C4B C5 CREB3 EBP ERGIC3 FAM209A MASP1 MUC1 PSMA4 SEC11C SLC10A1 SLC35H1 STOM
Entrez ID		6554	717
HPRD ID		01672	08939
Ensembl ID		ENSG00000100652	ENSG00000166278
Uniprot IDs		B2RA41 Q14973	A0A0G2JL69 B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6
PDB IDs		7FCI 7PQG 7PQQ 7VAD 7VAG 7WSI 7ZYI 8HRX 8HRY 8RQF	2I6Q 2I6S 2ODP 2ODQ 3ERB 8ACF 8ACI
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Protein Binding Endomembrane System Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Negative Regulation Of Sphingolipid Biosynthetic Process Membrane Organization Serine Palmitoyltransferase Complex Establishment Of Protein Localization To Membrane Establishment Of Protein Localization Cellular Localization Plasma Membrane Steroid Biosynthetic Process Vesicle-mediated Transport Lipid Metabolic Process Membrane Docking Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Ceramide Metabolic Process Myelination Axon Ensheathment Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Golgi Membrane Protein Insertion Into Membrane Protein Transport Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Nitric-oxide Synthase Complex Transmembrane Transport Organelle Localization By Membrane Tethering Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Lysosomal Membrane Sterol Metabolic Process SNARE Complex Organelle Fusion Sphingomyelin Metabolic Process Amino Acid Transmembrane Transport Regulation Of Membrane Lipid Metabolic Process Nuclear Inner Membrane Phospholipid Metabolic Process Nitrite Reductase (NO-forming) Activity	Complement Activation, Lectin Pathway Complement Activation Complement Activation, GZMK Pathway Complement Activation, Alternative Pathway Opsonization Symbiont Cell Surface Humoral Immune Response Complement Activation, Classical Pathway Endopeptidase Inhibitor Activity Regulation Of Humoral Immune Response Immune Effector Process Activation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Activation Of Membrane Attack Complex Positive Regulation Of Inflammatory Response To Antigenic Stimulus Extracellular Space Positive Regulation Of Immune System Process Regulation Of Complement Activation Positive Regulation Of Humoral Immune Response Innate Immune Response Receptor Ligand Activity Blood Microparticle Killing Of Cells Of Another Organism Positive Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response Regulation Of Mononuclear Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Production Defense Response To Symbiont Defense Response To Other Organism Antigen Binding Positive Regulation Of Transport Cell Killing Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Lipid Storage Regulation Of Vascular Endothelial Growth Factor Production C5L2 Anaphylatoxin Chemotactic Receptor Binding Chemokine Activity Regulation Of Acute Inflammatory Response Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Deacetylase Activity Cholesterol-5,6-oxide Hydrolase Activity Regulation Of Leukocyte Migration Extracellular Exosome Regulation Of Immune Response Leukocyte Migration
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