C8A

Gene Name		complement component 8, alpha polypeptide
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Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Complement Binding Protein Complex Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response
Pathways		Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: C8B C8G C9 CD59
Entrez ID		731
HPRD ID		00409
Ensembl ID		ENSG00000157131
Uniprot IDs		P07357
PDB IDs		2QOS 2QQH 2RD7 3OJY
Enriched GO Terms of Interacting Partners?		Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation, Alternative Pathway Cytolysis Regulation Of Inflammatory Response Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Innate Immune Response Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Immune Response Positive Regulation Of Immune System Process Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Immune Response Regulation Of Immune System Process Defense Response Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Immune Response Negative Regulation Of Activation Of Membrane Attack Complex Response To Stress Hemolysis By Symbiont Of Host Erythrocytes Negative Regulation Of Complement Activation Killing Of Cells Of Other Organism Regulation Of Metabolic Process Positive Regulation Of T Cell Proliferation Response To Stimulus Interaction With Host Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune Response Regulation Of T Cell Proliferation
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