SLC10A1 and EMC6

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		SLC10A1	EMC6
Description		solute carrier family 10 member 1	ER membrane protein complex subunit 6
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane EMC Complex Omegasome Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Bile Acid:sodium Symporter Activity Bile Acid Transmembrane Transporter Activity Symporter Activity	Protein Binding Membrane Insertase Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Lipid Transport Bile Acid And Bile Salt Transport Response To Nutrient Levels Response To Estrogen Response To Ethanol Symbiont Entry Into Host Cell Transmembrane Transport Cellular Response To Xenobiotic Stimulus	Autophagosome Assembly Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Recycling of bile acids and salts
Drugs		Bulevirtide
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483) Triglyceride levels ( 30108155)
Interacting Genes		115 interacting genes: ABHD16A ACSL5 AGPAT3 APOL3 ARL6IP6 ASGR1 ATP13A1 ATP6V0B BMP10 BTN2A2 C2 C3orf52 C8A CDIPT CFHR5 CFTR CLDN19 CMTM3 COX20 CXCL9 CYB5B CYB5R3 DERL1 DGAT2L6 EMC6 EMD FA2H FAM241B FAXDC2 FCER1G FDFT1 FKBP8 FXYD3 FXYD6 FXYD6-FXYD2 GAST GDE1 GIMAP5 GOSR2 GPR151 GPR152 IFITM2 IFITM3 IFTAP INSIG2 LNPEP LRP10 LSS MAL MALL MFSD6 MS4A1 MYADML2 NEU1 NINJ2 NKG7 ORMDL1 ORMDL2 ORMDL3 OTOP3 PEDS1-UBE2V1 PEX16 PKMYT1 PMP22 RABAC1 RTP2 RUSF1 SACM1L SCAMP4 SEC22A SELENOK SERP1 SFT2D1 SFT2D2 SFXN1 SLC12A7 SLC16A13 SLC25A46 SLC29A2 SLC35E4 SLC38A1 SLC38A7 SLC41A1 SLC66A2 SLC7A3 SMPD2 STATH STX12 STX7 TAP1 TFRC TMBIM1 TMEM119 TMEM120B TMEM121 TMEM147 TMEM222 TMEM234 TMEM239 TMEM242 TMEM60 TMEM97 TMUB2 TOMM6 TRARG1 TSPO2 TVP23B UBIAD1 UNC50 UPK1B VAMP3 VAPB YIF1A YIPF4 YIPF6	21 interacting genes: AQP6 AQP9 CD79A CREB3 EBP ELOVL4 ERGIC3 FAM209A FFAR2 MMD MUC1 PDZK1IP1 SLC10A1 SLC10A6 SLC35H1 SLC39A2 SLC71A2 SLC7A1 TLCD4 TMEM14B TMEM237
Entrez ID		6554	83460
HPRD ID		01672	14529
Ensembl ID		ENSG00000100652	ENSG00000127774
Uniprot IDs		B2RA41 Q14973	Q9BV81
PDB IDs		7FCI 7PQG 7PQQ 7VAD 7VAG 7WSI 7ZYI 8HRX 8HRY 8RQF	6WW7 6Z3W 7ADO 7ADP 8EOI 8J0N 8J0O 8S9S 9C7V
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Protein Binding Endomembrane System Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Negative Regulation Of Sphingolipid Biosynthetic Process Membrane Organization Serine Palmitoyltransferase Complex Establishment Of Protein Localization To Membrane Establishment Of Protein Localization Cellular Localization Plasma Membrane Steroid Biosynthetic Process Vesicle-mediated Transport Lipid Metabolic Process Membrane Docking Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Ceramide Metabolic Process Myelination Axon Ensheathment Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Golgi Membrane Protein Insertion Into Membrane Protein Transport Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Nitric-oxide Synthase Complex Transmembrane Transport Organelle Localization By Membrane Tethering Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Lysosomal Membrane Sterol Metabolic Process SNARE Complex Organelle Fusion Sphingomyelin Metabolic Process Amino Acid Transmembrane Transport Regulation Of Membrane Lipid Metabolic Process Nuclear Inner Membrane Phospholipid Metabolic Process Nitrite Reductase (NO-forming) Activity	Membrane Bile Acid:sodium Symporter Activity Transmembrane Transport Water Channel Activity Bile Acid And Bile Salt Transport Nitrate Transmembrane Transporter Activity One-carbon Compound Transport Fluid Transport Water Transport Channel Activity Organic Hydroxy Compound Transport Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Organic Anion Transport Positive Regulation Of Deacetylase Activity Cholesterol-5,6-oxide Hydrolase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport
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