C8A and C9

Number of citations: 0 (PubMedID 4063341)
Data Source: HPRD (in vitro)

		C8A	C9
Name		complement C8 alpha chain	complement C9
Structure
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex
	Molecular Function	Complement Binding Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway	Cell Killing Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Protein Homooligomerization Complement Activation, GZMK Pathway
Pathways		Terminal pathway of complement Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Zinc Zinc acetate	Copper
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		No GWAS studies recorded	Advanced age-related macular degeneration ( 26691988 ) Blood protein levels ( 30072576 ) Chronic kidney disease ( 20383146 ) Health literacy ( 31250787 ) Systemic lupus erythematosus ( 19838195 )
Interacting Genes		9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1	4 interacting genes: C8A CD59 CLU LAMTOR5
Entrez ID		731	735
HPRD ID		00409	00408
Ensembl ID		ENSG00000157131	ENSG00000113600
Uniprot IDs		P07357	P02748
PDB IDs		2QOS 2QQH 2RD7 3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H	5FMW 6DLW 6H03 6H04 7NYC 7NYD 8B0G 8B0H 8DE6
GO Terms Enriched among Interactors		Membrane Attack Complex Other Organism Cell Membrane Complement Activation Complement Activation, GZMK Pathway Transmembrane Transporter Complex Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Humoral Immune Response Immune Effector Process Killing Of Cells Of Another Organism Activation Of Immune Response Positive Regulation Of Immune System Process Cell Killing Plasma Membrane Positive Regulation Of Immune Response Membrane Regulation Of Immune System Process Virus Receptor Activity Regulation Of Immune Response Lysine Transport L-histidine Import Across Plasma Membrane Cobalt Ion Transmembrane Transporter Activity Negative Regulation Of Activation Of Membrane Attack Complex L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity Blood Microparticle Symbiont Entry Into Host Cell Ornithine Transport L-arginine Import Across Plasma Membrane Immune Response Negative Regulation Of Complement-dependent Cytotoxicity L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport Bile Acid:sodium Symporter Activity L-lysine Transmembrane Transport Biological Process Involved In Interaction With Host Ferrous Iron Transmembrane Transporter Activity Innate Immune Response Golgi Membrane Complement Binding Inorganic Cation Transmembrane Transporter Activity Cobalt Ion Transport Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity EMC Complex Aromatic Amino Acid Transport Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Defense Response To Symbiont	Complement Activation Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Complement-dependent Cytotoxicity Complement Binding Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement Activation Regulation Of Complement Activation Humoral Immune Response Complement Activation, Classical Pathway Protein Sequestering Activity Immune Effector Process Regulation Of Humoral Immune Response Activation Of Immune Response Protein Localization To Lysosome Protein Localization To Vacuole Positive Regulation Of Immune Response Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Blood Microparticle Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Immune Response Central Nervous System Myelin Maintenance Immune Complex Clearance Positive Regulation Of Immune System Process Negative Regulation Of Immune Response Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Response To Other Organism Positive Regulation Of Inclusion Body Assembly Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Ragulator Complex Immune Response Regulation Of Neurofibrillary Tangle Assembly Membrane Attack Complex Other Organism Cell Membrane Protein Import Response To External Biotic Stimulus Spherical High-density Lipoprotein Particle FNIP-folliculin RagC/D GAP Microglial Cell Proliferation Extracellular Space Protein Carrier Chaperone Protein-containing Complex Binding Complement Activation, GZMK Pathway Regulation Of Immune System Process Transmembrane Transporter Complex Response To Virus Response To Misfolded Protein Negative Regulation Of Amyloid Fibril Formation