C8A and C9

Number of citations of the paper that reports this interaction (PMID 3624872)
7

Data Source:
HPRD (in vitro)

		C8A	C9
Gene Name		complement component 8, alpha polypeptide	complement component 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Membrane Attack Complex Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Complement Binding Protein Complex Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response	Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Hemolysis By Symbiont Of Host Erythrocytes Regulation Of Complement Activation Innate Immune Response
Pathways		Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System	Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146)
Protein-Protein Interactions		4 interactors: C8B C8G C9 CD59	3 interactors: C8A CD59 CLU
Entrez ID		731	735
HPRD ID		00409	00408
Ensembl ID		ENSG00000157131	ENSG00000113600
Uniprot IDs		P07357	P02748
PDB IDs		2QOS 2QQH 2RD7 3OJY
Enriched GO Terms of Interacting Partners?		Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation, Alternative Pathway Cytolysis Regulation Of Inflammatory Response Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Innate Immune Response Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Immune Response Positive Regulation Of Immune System Process Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Immune Response Regulation Of Immune System Process Defense Response Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Immune Response Negative Regulation Of Activation Of Membrane Attack Complex Response To Stress Hemolysis By Symbiont Of Host Erythrocytes Negative Regulation Of Complement Activation Killing Of Cells Of Other Organism Regulation Of Metabolic Process Positive Regulation Of T Cell Proliferation Response To Stimulus Interaction With Host Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune Response Regulation Of T Cell Proliferation	Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Negative Regulation Of Activation Of Membrane Attack Complex Protein Activation Cascade Immune Response Regulation Of Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Defense Response Positive Regulation Of Neurofibrillary Tangle Assembly Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Central Nervous System Myelin Maintenance Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Immune System Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Regulation Of Protein Metabolic Process Regulation Of Protein Processing Blood Coagulation Hemostasis Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Negative Regulation Of Beta-amyloid Formation Complement Activation, Alternative Pathway Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Negative Regulation Of Complement Activation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Body Fluid Levels Glial Cell Proliferation Wound Healing Response To Misfolded Protein Regulation Of Beta-amyloid Formation Positive Regulation Of Immune Response Regulation Of Inclusion Body Assembly
Tagcloud ?			astroglial axotomy bromodeoxyuridine c3d complement degeneration degenerative enables gfap glial hypoglossal immunoreactivity injured ipsilateral massive microglial motorneuron nerve oligodendroglial ox42 phagocytosis principally profound rca ricin situation somata transection transferrin
Tagcloud (Difference) ?			astroglial axotomy bromodeoxyuridine c3d complement degeneration degenerative enables gfap glial hypoglossal immunoreactivity injured ipsilateral massive microglial motorneuron nerve oligodendroglial ox42 phagocytosis principally profound rca ricin situation somata transection transferrin
Tagcloud (Intersection) ?