TNFSF4 and TNFRSF4

Number of citations of the paper that reports this interaction (PMID 12134113)
1

Data Source:
HPRD (in vivo)

		TNFSF4	TNFRSF4
Gene Name		tumor necrosis factor (ligand) superfamily, member 4	tumor necrosis factor receptor superfamily, member 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Cell Surface	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor Receptor Superfamily Binding	Tumor Necrosis Factor-activated Receptor Activity
	Biological Process	Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Immune Response Signal Transduction Cholesterol Metabolic Process Positive Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Cellular Response To Nitrogen Dioxide CD4-positive, Alpha-beta T Cell Costimulation T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of Cytokine Secretion Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Chemokine (C-C Motif) Ligand 11 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Memory T Cell Activation Positive Regulation Of T-helper 2 Cell Activation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes	Inflammatory Response Immune Response Cellular Defense Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cytokine Secretion Positive Regulation Of Immunoglobulin Secretion
Pathways
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) Systemic lupus erythematosus ( 23273568 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		2 interactors: TNFRSF4 TRAF2	8 interactors: SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5
Entrez ID		7292	7293
HPRD ID		04668	02636
Ensembl ID		ENSG00000117586	ENSG00000186827
Uniprot IDs		P23510 Q8IV74	P43489
PDB IDs		2HEV	1D0A 2HEV 2HEY
Enriched GO Terms of Interacting Partners?		Regulation Of Immunoglobulin Secretion Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of Cell Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Lymphocyte Activation Regulation Of Protein Secretion Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cytokine Production Cellular Response To Cytokine Stimulus Positive Regulation Of Immunoglobulin Secretion Regulation Of Protein Transport Regulation Of Secretion Positive Regulation Of Protein Homodimerization Activity Regulation Of Establishment Of Protein Localization Cellular Response To Nitric Oxide Response To Cytokine Regulation Of Protein Kinase Activity Response To Nitric Oxide Regulation Of Kinase Activity Regulation Of Protein Localization Positive Regulation Of Immune System Process Positive Regulation Of T Cell Cytokine Production Protein Homotrimerization Regulation Of Protein Homodimerization Activity Cellular Response To Reactive Nitrogen Species Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Phosphorylation Regulation Of T Cell Cytokine Production Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of NIK/NF-kappaB Signaling Protein K63-linked Ubiquitination Protein Trimerization Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cytokine Secretion Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation NIK/NF-kappaB Signaling Positive Regulation Of Immunoglobulin Production Defense Response Regulation Of NIK/NF-kappaB Signaling Protein Autoubiquitination Positive Regulation Of B Cell Proliferation	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immunoglobulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Regulation Of Cytokine Production Regulation Of Protein Homodimerization Activity Activation Of NF-kappaB-inducing Kinase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of T Cell Cytokine Production Negative Regulation Of Cytokine Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Protein Trimerization Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cytokine Secretion Positive Regulation Of Cytokine Production Involved In Immune Response Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Cellular Localization Positive Regulation Of Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Secretion Regulation Of Cytokine Production Involved In Immune Response Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Cellular Response To Nitrogen Dioxide Response To Nitrogen Dioxide T-helper 2 Cell Activation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes CD4-positive, Alpha-beta T Cell Costimulation Memory T Cell Activation Cellular Response To Tumor Necrosis Factor
Tagcloud ?		atp6v0d2 ctsk gcgr gpnmb granuloma instillation intratracheal lilrb4 lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts toxicological trem2 upregulated	assembles bcl10 carma1 cbm cd134 cd252 cd28 contributor detergent dim directs expand malt1 microdomains ox40 ox40l persist pkctheta primed rafts raising rip1 signalosome superfamily tcr translocates works
Tagcloud (Difference) ?		atp6v0d2 ctsk gcgr gpnmb granuloma instillation intratracheal lilrb4 lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts toxicological trem2 upregulated	assembles bcl10 carma1 cbm cd134 cd252 cd28 contributor detergent dim directs expand malt1 microdomains ox40 ox40l persist pkctheta primed rafts raising rip1 signalosome superfamily tcr translocates works
Tagcloud (Intersection) ?