TNFSF4 and TNFRSF4

Number of citations of the paper that reports this interaction (PubMedID 12134113)
0

Data Source:
HPRD (in vivo)

		TNFSF4	TNFRSF4
Description		TNF superfamily member 4	TNF receptor superfamily member 4
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Virus Signaling Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Positive Regulation Of T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Symbiont Entry Into Host Cell
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25337690) Asthma ( 32296059 31361310 27182965 30929738 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 24999842) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) IgA levels ( 28628107) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 28714469 19838193 27399966 26663301 26502338 23273568 32771030 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Vein graft stenosis in coronary artery bypass grafting ( 25881214)	Inflammatory bowel disease ( 23128233)
Interacting Genes		2 interacting genes: TNFRSF4 TRAF2	10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5
Entrez ID		7292	7293
HPRD ID		04668	02636
Ensembl ID		ENSG00000117586	ENSG00000186827
Uniprot IDs		A0A024R937 P23510	A0A8V8TQH5 P43489
PDB IDs		2HEV	1D0A 2HEV 2HEY 6OGX 6OKM 6OKN 7YK4 8AG1
Enriched GO Terms of Interacting Partners?		Regulation Of Immunoglobulin Production Regulation Of Membrane Protein Ectodomain Proteolysis Leukotriene Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Positive Regulation Of Immune Effector Process Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Chronic Inflammatory Response Regulation Of B Cell Proliferation Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Receptor Binding Regulation Of Protein Metabolic Process Interleukin-10 Receptor Binding Mononuclear Cell Proliferation Lymphocyte Activation Negative Regulation Of Interleukin-18 Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Lymphocyte Proliferation Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Activity Positive Regulation Of B Cell Activation Regulation Of Cytokine Activity Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Cholesterol Storage Sterol O-acyltransferase Activity Cholesterol O-acyltransferase Activity RNA Export From Nucleus Nuclear Export Positive Regulation Of Chromatin Organization Negative Regulation Of RNA Export From Nucleus Positive Regulation Of Heterochromatin Formation MRNA Export From Nucleus MRNA Transport MRNA Export From Nucleus In Response To Heat Stress Nuclear Matrix Organization RNA Import Into Nucleus Sphingolipid Binding TORC2 Complex Disassembly Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex IRE1-TRAF2-ASK1 Complex TORC1 Complex Assembly CD40 Receptor Binding	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Ubiquitin Protein Ligase Binding Regulation Of MRNA Metabolic Process Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of DNA-binding Transcription Factor Activity Regulation Of MRNA Stability MRNA Stabilization CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of RNA Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of RNA Catabolic Process Protein Phosphatase Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of T-helper Cell Differentiation Regulation Of Immune Response Post-transcriptional Regulation Of Gene Expression Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Zinc Ion Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Activity Negative Regulation Of Alpha-beta T Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Immune System Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Proliferation TORC2 Complex Disassembly Regulation Of T Cell Cytokine Production
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