TNFSF4 and LTB4R

		TNFSF4	LTB4R
Description		TNF superfamily member 4	leukotriene B4 receptor
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane	Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding	Nucleotide Binding Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Virus Signaling Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Positive Regulation Of T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes	Muscle Contraction Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway
Pathways		TNFs bind their physiological receptors	Leukotriene receptors G alpha (q) signalling events
Drugs			Amelubant Morniflumate Leukotriene B4
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25337690) Asthma ( 32296059 31361310 27182965 30929738 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 24999842) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) IgA levels ( 28628107) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 28714469 19838193 27399966 26663301 26502338 23273568 32771030 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Vein graft stenosis in coronary artery bypass grafting ( 25881214)	Parent of origin effect on language impairment (paternal) ( 24571439)
Interacting Genes		2 interacting genes: TNFRSF4 TRAF2	4 interacting genes: GNA15 GNAI2 GRK6 YWHAG
Entrez ID		7292	1241
HPRD ID		04668	03320
Ensembl ID		ENSG00000117586	ENSG00000213903
Uniprot IDs		A0A024R937 P23510	Q15722
PDB IDs		2HEV	7K15 7VKT
Enriched GO Terms of Interacting Partners?		Regulation Of Immunoglobulin Production Regulation Of Membrane Protein Ectodomain Proteolysis Leukotriene Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Positive Regulation Of Immune Effector Process Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Chronic Inflammatory Response Regulation Of B Cell Proliferation Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Receptor Binding Regulation Of Protein Metabolic Process Interleukin-10 Receptor Binding Mononuclear Cell Proliferation Lymphocyte Activation Negative Regulation Of Interleukin-18 Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Lymphocyte Proliferation Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Activity Positive Regulation Of B Cell Activation Regulation Of Cytokine Activity Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Cholesterol Storage Sterol O-acyltransferase Activity Cholesterol O-acyltransferase Activity RNA Export From Nucleus Nuclear Export Positive Regulation Of Chromatin Organization Negative Regulation Of RNA Export From Nucleus Positive Regulation Of Heterochromatin Formation MRNA Export From Nucleus MRNA Transport MRNA Export From Nucleus In Response To Heat Stress Nuclear Matrix Organization RNA Import Into Nucleus Sphingolipid Binding TORC2 Complex Disassembly Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex IRE1-TRAF2-ASK1 Complex TORC1 Complex Assembly CD40 Receptor Binding	G Protein-coupled Acetylcholine Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction G Protein-coupled Receptor Binding Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Adaptive Immune Response Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Regulation Of T Cell Mediated Immunity Memory T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of T Cell Costimulation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Activation G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Nematode Protein Kinase C Inhibitor Activity Signal Transduction Negative Regulation Of Lymphocyte Activation Beta-adrenergic Receptor Kinase Activity Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Negative Regulation Of Cell Activation Negative Regulation Of Regulatory T Cell Differentiation G Protein-coupled Receptor Kinase Activity Positive Regulation Of T-helper 2 Cell Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of T Cell Activation Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Calcium Ion-dependent Exocytosis G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Immune Effector Process Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion
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