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TNFSF4
Gene Name
tumor necrosis factor (ligand) superfamily, member 4
Image
Gene Ontology Annotations
Cellular Component
Extracellular Space
Integral Component Of Plasma Membrane
Cell Surface
Molecular Function
Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Tumor Necrosis Factor Receptor Superfamily Binding
Biological Process
Defense Response To Nematode
Acute Inflammatory Response
Positive Regulation Of T Cell Cytokine Production
Regulation Of Adaptive Immune Response
Positive Regulation Of Type 2 Immune Response
Positive Regulation Of Immunoglobulin Mediated Immune Response
Immune Response
Signal Transduction
Cholesterol Metabolic Process
Positive Regulation Of Cell Proliferation
Response To Virus
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-17 Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-6 Production
Memory T Cell Activation
T-helper 2 Cell Activation
Response To Nitrogen Dioxide
Cellular Response To Nitrogen Dioxide
CD4-positive, Alpha-beta T Cell Costimulation
T Cell Proliferation
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of Memory T Cell Differentiation
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Regulatory T Cell Differentiation
Negative Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of T-helper 2 Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Alpha-beta T Cell Proliferation
Negative Regulation Of Cytokine Secretion
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of B Cell Activation
Positive Regulation Of Immunoglobulin Secretion
Cellular Response To Lipopolysaccharide
Cellular Response To Prostaglandin E Stimulus
Chemokine (C-C Motif) Ligand 11 Production
Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation
Positive Regulation Of Memory T Cell Activation
Positive Regulation Of T-helper 2 Cell Activation
Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes
Pathways
Drugs
Diseases
GWAS
Celiac disease (
20190752
)
Crohn's disease (
21102463
)
Diabetic retinopathy (
21441570
)
Systemic lupus erythematosus (
23273568
19838193
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Protein-protein Interactions
2 interactors:
TNFRSF4
TRAF2
Entrez ID
7292
HPRD ID
04668
Ensembl ID
ENSG00000117586
Uniprot IDs
P23510
Q8IV74
PDB IDs
2HEV
Enriched GO Terms of Interacting Partners
?
Regulation Of Immunoglobulin Secretion
Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Response To Tumor Necrosis Factor
Positive Regulation Of Cell Activation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Lymphocyte Activation
Regulation Of Protein Secretion
Cytokine-mediated Signaling Pathway
Regulation Of Cell Activation
Negative Regulation Of Glial Cell Apoptotic Process
Regulation Of Cytokine Production
Cellular Response To Cytokine Stimulus
Positive Regulation Of Immunoglobulin Secretion
Regulation Of Protein Transport
Regulation Of Secretion
Positive Regulation Of Protein Homodimerization Activity
Regulation Of Establishment Of Protein Localization
Cellular Response To Nitric Oxide
Response To Cytokine
Regulation Of Protein Kinase Activity
Response To Nitric Oxide
Regulation Of Kinase Activity
Regulation Of Protein Localization
Positive Regulation Of Immune System Process
Positive Regulation Of T Cell Cytokine Production
Protein Homotrimerization
Regulation Of Protein Homodimerization Activity
Cellular Response To Reactive Nitrogen Species
Programmed Cell Death
Regulation Of Cellular Localization
Cell Death
Death
Regulation Of Protein Phosphorylation
Regulation Of T Cell Cytokine Production
Activation Of NF-kappaB-inducing Kinase Activity
Positive Regulation Of NIK/NF-kappaB Signaling
Protein K63-linked Ubiquitination
Protein Trimerization
Positive Regulation Of Interleukin-2 Production
Negative Regulation Of Cytokine Secretion
Immune Response
Regulation Of Immune System Process
Regulation Of Phosphorylation
NIK/NF-kappaB Signaling
Positive Regulation Of Immunoglobulin Production
Defense Response
Regulation Of NIK/NF-kappaB Signaling
Protein Autoubiquitination
Positive Regulation Of B Cell Proliferation
Tagcloud
?
atp6v0d2
ctsk
gcgr
gpnmb
granuloma
instillation
intratracheal
lilrb4
lpo
marco
mmp12
mmp7
mreg
mt3
nanotube
nanotubes
padi1
persistence
persistently
rnase9
slc26a4
spp1
subchronic
suspensions
swcnt
swcnts
toxicological
trem2
upregulated