VDAC1 and HK1

Number of citations of the paper that reports this interaction (PubMedID 10978502)
0

Data Source:
HPRD (in vivo)

		VDAC1	HK1
Description		voltage dependent anion channel 1	hexokinase 1
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Plasma Membrane Membrane Mitochondrial Membrane Mitochondrial Nucleoid Membrane Raft Synapse Pore Complex Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Membrane Raft
	Molecular Function	Nucleotide Binding Voltage-gated Monoatomic Ion Channel Activity Protein Binding ATP Binding Oxysterol Binding Lipid Binding Voltage-gated Monoatomic Anion Channel Activity Porin Activity Cholesterol Binding Protein Kinase Binding Phosphatidylcholine Binding Identical Protein Binding Transmembrane Transporter Binding Ceramide Binding	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity Peptidoglycan Binding Glucosamine Kinase Activity
	Biological Process	Behavioral Fear Response Monoatomic Ion Transport Monoatomic Anion Transport Lipid Transport Apoptotic Process Chemical Synaptic Transmission Neuron-neuron Synaptic Transmission Learning Epithelial Cell Differentiation Calcium Import Into The Mitochondrion Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Monoatomic Anion Transmembrane Transport Negative Regulation Of Calcium Import Into The Mitochondrion Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Type 2 Mitophagy Mitochondrial Transmembrane Transport Negative Regulation Of Reactive Oxygen Species Metabolic Process	Intracellular Glucose Homeostasis Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response GDP-mannose Biosynthetic Process Hexose Metabolic Process Organophosphate Metabolic Process Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis GDP-mannose Biosynthetic Process From Mannose Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Pyruvate metabolism Mitochondrial calcium ion transport	Synthesis of GDP-mannose Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis
Drugs		Aluminium monostearate Cannabidiol Medical Cannabis Nabiximols	alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Alopecia areata ( 25608926) Metabolite levels ( 23823483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Glycated hemoglobin levels ( 34059833 19096518 31213470 29483669 28898252 20858683) Glycemic traits (pregnancy) ( 23903356) HDL cholesterol levels ( 32203549) Hematocrit ( 19862010 32888494 27863252) Hemoglobin ( 32888494 19862010) Hemoglobin A1c levels ( 29844224 31217584) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 20139978 27863252 32888494) Mean corpuscular volume ( 27863252 32888494 20139978) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Red blood cell count ( 27863252 32888494 20139978) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		26 interacting genes: ADRB2 BAK1 BAX BCL2L1 BCL2L11 CKMT1A CKMT1B CSNK2B DUX4 DYNLT1 DYNLT3 GSN HK1 KLHL40 MCL1 PLAT PPIF PRKCE PRKN RAF1 RNF31 SAMM50 STUB1 SUMO4 TOMM20 TUBA4A	6 interacting genes: APP CFTR ENO2 SCMH1 VDAC1 VDAC2
Entrez ID		7416	3098
HPRD ID		05137	00809
Ensembl ID		ENSG00000213585	ENSG00000156515
Uniprot IDs		A0A1L1UHR1 B3KTS5 P21796	A0A994J753 A8K7J7 B3KXY9 P19367 P78542 Q59FD4
PDB IDs		2JK4 2K4T 5JDP 5XDN 5XDO 6G6U 6G73 6TIQ 6TIR 7QI2 8J0O	1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
Enriched GO Terms of Interacting Partners?		Mitochondrial Outer Membrane Bcl-2 Family Protein Complex Apoptotic Mitochondrial Changes Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrion Organization Mitochondrial Membrane Organization Mitochondrion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Release Of Cytochrome C From Mitochondria Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Permeability BH3 Domain Binding Regulation Of Mitochondrial Membrane Potential Regulation Of Apoptotic Signaling Pathway Cellular Response To Topologically Incorrect Protein Positive Regulation Of Mitochondrial Membrane Permeability Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Membrane Permeability Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Channel Activity Programmed Cell Death Thymocyte Apoptotic Process Cell Death Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Programmed Cell Death Regulation Of Proteolysis Response To Stress Regulation Of IRE1-mediated Unfolded Protein Response BAK Complex B Cell Negative Selection Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Regulation Of Protein-containing Complex Assembly Cellular Response To Unfolded Protein Mitochondrial Fusion Positive Regulation Of Intracellular Signal Transduction Membrane Organization Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Establishment Of Protein Localization To Mitochondrion	Membrane Raft Voltage-gated Monoatomic Anion Channel Activity Porin Activity Ceramide Binding Voltage-gated Monoatomic Ion Channel Activity Pore Complex Monoatomic Anion Transmembrane Transport Oxysterol Binding Monoatomic Anion Transport Mitochondrial Transmembrane Transport Phosphatidylcholine Binding Mitochondrial Transport Regulation Of Monoatomic Ion Transmembrane Transport Mitochondrial Nucleoid Cholesterol Binding Lipid Transport Cellular Response To CAMP Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transport Response To CAMP Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Anion Channel Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monoatomic Anion Transport Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Calcium Import Into The Mitochondrion Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process
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