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VDAC1 and BAK1
Number of citations of the paper that reports this interaction (PubMedID
9843949
)
48
Data Source:
HPRD
(in vitro)
VDAC1
BAK1
Description
voltage dependent anion channel 1
BCL2 antagonist/killer 1
Image
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Permeability Transition Pore Complex
Plasma Membrane
Membrane
Mitochondrial Membrane
Mitochondrial Nucleoid
Membrane Raft
Synapse
Pore Complex
Extracellular Exosome
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Cytosol
Membrane
Mitochondrial Membrane
Pore Complex
Bcl-2 Family Protein Complex
BAK Complex
Molecular Function
Nucleotide Binding
Voltage-gated Monoatomic Ion Channel Activity
Protein Binding
ATP Binding
Oxysterol Binding
Lipid Binding
Voltage-gated Monoatomic Anion Channel Activity
Porin Activity
Cholesterol Binding
Protein Kinase Binding
Phosphatidylcholine Binding
Identical Protein Binding
Transmembrane Transporter Binding
Ceramide Binding
Protein Binding
Channel Activity
Porin Activity
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Transmembrane Transporter Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Protein-folding Chaperone Binding
BH Domain Binding
Biological Process
Behavioral Fear Response
Monoatomic Ion Transport
Monoatomic Anion Transport
Lipid Transport
Apoptotic Process
Chemical Synaptic Transmission
Neuron-neuron Synaptic Transmission
Learning
Epithelial Cell Differentiation
Calcium Import Into The Mitochondrion
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Transmembrane Transport
Monoatomic Anion Transmembrane Transport
Negative Regulation Of Calcium Import Into The Mitochondrion
Regulation Of Mitophagy
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Type 2 Mitophagy
Mitochondrial Transmembrane Transport
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Leukocyte Homeostasis
B Cell Homeostasis
B Cell Apoptotic Process
Release Of Cytochrome C From Mitochondria
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
Apoptotic Process
Mitochondrial Fusion
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Response To Fungus
Response To Mycotoxin
Response To UV-C
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Gene Expression
Endocrine Pancreas Development
Animal Organ Regeneration
Positive Regulation Of Protein-containing Complex Assembly
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Monoatomic Ion Transmembrane Transport
Cellular Response To Unfolded Protein
Cellular Response To UV
Limb Morphogenesis
Response To Hydrogen Peroxide
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Fibroblast Apoptotic Process
Response To Ethanol
Positive Regulation Of Proteolysis
Regulation Of Mitochondrial Membrane Permeability
Post-embryonic Camera-type Eye Morphogenesis
Homeostasis Of Number Of Cells
Epithelial Cell Proliferation
Regulation Of Transport
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Regulation Of Mitochondrial Membrane Potential
Vagina Development
Calcium Ion Transport Into Cytosol
Regulation Of Biological Quality
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Cellular Response To Mechanical Stimulus
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process Involved In Blood Vessel Morphogenesis
Regulation Of Intracellular Signal Transduction
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of Apoptotic Signaling Pathway
Pathways
Mitochondrial protein import
PINK1-PRKN Mediated Mitophagy
Ub-specific processing proteases
Pyruvate metabolism
Mitochondrial calcium ion transport
Activation and oligomerization of BAK protein
Release of apoptotic factors from the mitochondria
Pyroptosis
Drugs
Aluminium monostearate
Cannabidiol
Medical Cannabis
Nabiximols
Diseases
GWAS
Alopecia areata (
25608926
)
Metabolite levels (
23823483
)
Systemic lupus erythematosus (
28714469
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Autism spectrum disorder or schizophrenia (
28540026
)
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) (
28112199
)
Body mass index (
26426971
)
Chronic lymphocytic leukemia (
24292274
28165464
23770605
22700719
)
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
27841878
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Hematological parameters (
19820697
)
Lung cancer (
28604730
)
Multiple sclerosis and systolic blood pressure (pleiotropy) (
26920376
)
Neutrophil percentage of granulocytes (
27863252
)
Obesity-related traits (
23251661
)
Platelet count (
29066854
27863252
29403010
32888494
33545615
28031487
20139978
26805783
25705162
24026423
22139419
22423221
23263863
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Schizophrenia (
30285260
)
Spleen volume (
34128465
)
Sum eosinophil basophil counts (
27863252
)
Testicular germ cell tumor (
23666239
23666240
28604732
28604728
19483681
)
Interacting Genes
26 interacting genes:
ADRB2
BAK1
BAX
BCL2L1
BCL2L11
CKMT1A
CKMT1B
CSNK2B
DUX4
DYNLT1
DYNLT3
GSN
HK1
KLHL40
MCL1
PLAT
PPIF
PRKCE
PRKN
RAF1
RNF31
SAMM50
STUB1
SUMO4
TOMM20
TUBA4A
20 interacting genes:
ARHGDIA
BAX
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BID
DBN1
ERN1
HERC1
HSD17B4
HSPD1
MCL1
MFN1
NFKBIB
TP53
UBE3A
VDAC1
VDAC2
Entrez ID
7416
578
HPRD ID
05137
02744
Ensembl ID
ENSG00000213585
ENSG00000030110
Uniprot IDs
A0A1L1UHR1
B3KTS5
P21796
A0A0S2Z391
Q16611
PDB IDs
2JK4
2K4T
5JDP
5XDN
5XDO
6G6U
6G73
6TIQ
6TIR
7QI2
8J0O
1BXL
2IMS
2IMT
2JBY
2JCN
2LP8
2M5B
2XPX
2YV6
3I1H
3QBR
4D2L
4U2U
4U2V
4UF1
5AJK
5FMI
5FMK
5VWV
5VWW
5VWX
5VWY
5VWZ
5VX0
5VX1
6ODH
6UXM
6UXN
6UXO
6UXP
6UXQ
6UXR
7K02
7LK4
7M5A
7M5B
7OFM
7OFO
8CZF
8CZG
8CZH
8GSV
8IGC
8IVB
8SRX
8SRY
8UKY
8Y1Y
8Y1Z
Enriched GO Terms of Interacting Partners
?
Mitochondrial Outer Membrane
Bcl-2 Family Protein Complex
Apoptotic Mitochondrial Changes
Regulation Of Release Of Cytochrome C From Mitochondria
Mitochondrion Organization
Mitochondrial Membrane Organization
Mitochondrion
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Mitochondrion Organization
Extrinsic Apoptotic Signaling Pathway
Regulation Of Mitochondrial Membrane Permeability
Release Of Cytochrome C From Mitochondria
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Membrane Permeability
BH3 Domain Binding
Regulation Of Mitochondrial Membrane Potential
Regulation Of Apoptotic Signaling Pathway
Cellular Response To Topologically Incorrect Protein
Positive Regulation Of Mitochondrial Membrane Permeability
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Membrane Permeability
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of Intracellular Signal Transduction
Regulation Of Intrinsic Apoptotic Signaling Pathway
Apoptotic Process
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Channel Activity
Programmed Cell Death
Thymocyte Apoptotic Process
Cell Death
Leukocyte Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Programmed Cell Death
Regulation Of Proteolysis
Response To Stress
Regulation Of IRE1-mediated Unfolded Protein Response
BAK Complex
B Cell Negative Selection
Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Regulation Of Protein-containing Complex Assembly
Cellular Response To Unfolded Protein
Mitochondrial Fusion
Positive Regulation Of Intracellular Signal Transduction
Membrane Organization
Negative Regulation Of Programmed Cell Death
Regulation Of Programmed Cell Death
Establishment Of Protein Localization To Mitochondrion
Apoptotic Mitochondrial Changes
Release Of Cytochrome C From Mitochondria
Mitochondrion Organization
Mitochondrial Outer Membrane
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Channel Activity
Bcl-2 Family Protein Complex
Intrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
BH3 Domain Binding
Negative Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Programmed Cell Death
Regulation Of Membrane Permeability
Pore Complex
Apoptotic Process
Mitochondrial Membrane
Programmed Cell Death
Cell Death
Mitochondrial Membrane Organization
Mitochondrion
Mitochondrial Fusion
Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Regulation Of Mitochondrial Membrane Potential
Regulation Of Programmed Cell Death
Positive Regulation Of Mitochondrial Membrane Permeability
Cellular Response To Stress
Positive Regulation Of Membrane Permeability
Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Regulation Of Intrinsic Apoptotic Signaling Pathway
DNA Damage Response
Negative Regulation Of Autophagy
Intracellular Signal Transduction
Neuron Apoptotic Process
Regulation Of Autophagy
Regulation Of Release Of Cytochrome C From Mitochondria
Transmembrane Transport
Epithelial Cell Apoptotic Process
Ovarian Follicle Development
Mononuclear Cell Proliferation
Leukocyte Apoptotic Process
Response To Gamma Radiation
Leukocyte Proliferation
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
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Tagcloud (Intersection)
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