VDAC1 and BCL2L11

Number of citations of the paper that reports this interaction (PMID 12118373)
13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		VDAC1	BCL2L11
Gene Name		voltage-dependent anion channel 1	BCL2-like 11 (apoptosis facilitator)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Membrane Mitochondrial Nucleoid Pore Complex Extracellular Vesicular Exosome	Mitochondrial Outer Membrane Cytosol Microtubule Endomembrane System Extrinsic Component Of Membrane BIM-BCL-xl Complex BIM-BCL-2 Complex
	Molecular Function	Protein Binding Voltage-gated Anion Channel Activity Porin Activity Protein Kinase Binding	Protein Binding Microtubule Binding
	Biological Process	Behavioral Fear Response Anion Transport Apoptotic Process Neuron-neuron Synaptic Transmission Learning Viral Process Epithelial Cell Differentiation Regulation Of Anion Transport Transmembrane Transport	In Utero Embryonic Development B Cell Homeostasis B Cell Apoptotic Process Kidney Development Myeloid Cell Homeostasis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-matrix Adhesion Spermatogenesis Brain Development Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mammary Gland Development Positive Regulation Of Protein Homooligomerization Response To Endoplasmic Reticulum Stress Tube Formation Odontogenesis Of Dentin-containing Tooth T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ear Development Positive Regulation Of Cell Cycle Regulation Of Organ Growth Neurotrophin TRK Receptor Signaling Pathway Developmental Pigmentation Regulation Of Developmental Pigmentation Spleen Development Thymus Development Post-embryonic Organ Morphogenesis Positive Regulation Of Apoptotic Process By Virus Cellular Process Regulating Host Cell Cycle In Response To Virus Thymocyte Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Mitochondrial protein import	Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Activation of BIM and translocation to mitochondria NRAGE signals death through JNK Programmed Cell Death Activation of BH3-only proteins p75 NTR receptor-mediated signalling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461) Dehydroepiandrosterone sulphate levels ( 21533175) Primary sclerosing cholangitis ( 21151127)
Protein-Protein Interactions		20 interactors: ADRB2 BAK1 BAX BCL2L1 BCL2L11 CKMT1A CKMT1B CSNK2B DYNLT1 DYNLT3 GSN HK1 KLHL40 MCL1 PPIF PRKCE RAF1 SUMO4 TOMM20 TUBA4A	26 interactors: AKT1 APP ATP6V1G1 AURKB BCL2 BCL2A1 BCL2L1 BCL2L2 BTK DYNLL1 DYNLL2 FEM1C FGL1 GNB2L1 GTF2I MAGEA11 MAPK10 MAPK8 MAPK9 MCL1 MEX3D RIOK3 SMARCB1 TRIM2 VDAC1 YWHAB
Entrez ID		7416	10018
HPRD ID		05137	04828
Ensembl ID		ENSG00000213585	ENSG00000153094
Uniprot IDs		B3KTS5 P21796	O43521
PDB IDs		2JK4 2K4T	1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4B4S
Enriched GO Terms of Interacting Partners?		Apoptotic Mitochondrial Changes Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Organization Mitochondrial Transport Positive Regulation Of Release Of Cytochrome C From Mitochondria Thymocyte Apoptotic Process B Cell Apoptotic Process Post-embryonic Organ Morphogenesis Positive Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Mitochondrion Organization Mitochondrion Organization Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Mitochondrion Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Apoptotic Process Apoptotic Signaling Pathway Transport Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization B Cell Negative Selection Apoptotic Process Involved In Morphogenesis Organelle Organization Apoptotic Process Involved In Development Establishment Of Localization In Cell Intracellular Transport Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Apoptotic Process Involved In Embryonic Digit Morphogenesis Post-embryonic Camera-type Eye Morphogenesis Positive Regulation Of Intracellular Signal Transduction Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction B Cell Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Developmental Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process	Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand JUN Phosphorylation Intracellular Signal Transduction Apoptotic Mitochondrial Changes Regulation Of Signal Transduction Response To Radiation Positive Regulation Of Signal Transduction Response To Light Stimulus Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Stress Positive Regulation Of Intracellular Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Response To UV Regulation Of Establishment Of Protein Localization Fc Receptor Signaling Pathway Negative Regulation Of Cell Death Immune Response-regulating Signaling Pathway Regulation Of Neuron Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Defense Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Anoikis
Tagcloud ?		000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin tsg101 ultracentrifugation vesicle	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin tsg101 ultracentrifugation vesicle	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?