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B4GALT1 and CDK11A
Number of citations of the paper that reports this interaction (PubMedID
11506180
)
0
Data Source:
BioGRID
(pull down)
B4GALT1
CDK11A
Description
beta-1,4-galactosyltransferase 1
cyclin dependent kinase 11A
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Trans Cisterna
Golgi Membrane
Extracellular Region
Extracellular Space
Golgi Apparatus
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Basolateral Plasma Membrane
Desmosome
Filopodium
Secretory Granule Membrane
Brush Border Membrane
Golgi Cisterna Membrane
Protein-containing Complex
Azurophil Granule Membrane
Cell Projection
Extracellular Exosome
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Cytoplasm
Molecular Function
Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity
N-acetyllactosamine Synthase Activity
Lactose Synthase Activity
Galactosyltransferase Activity
Transferase Activity
Glycosyltransferase Activity
Manganese Ion Binding
UDP-galactosyltransferase Activity
Identical Protein Binding
Alpha-tubulin Binding
Metal Ion Binding
Beta-tubulin Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
Biological Process
Epithelial Cell Development
Acute Inflammatory Response
Carbohydrate Metabolic Process
Lactose Biosynthetic Process
Galactose Metabolic Process
Protein Glycosylation
Protein N-linked Glycosylation
Lipid Metabolic Process
Cell Adhesion
Binding Of Sperm To Zona Pellucida
Penetration Of Zona Pellucida
Cell Population Proliferation
Glycoprotein Biosynthetic Process
Oligosaccharide Biosynthetic Process
Extracellular Matrix Organization
Wound Healing
Positive Regulation Of Apoptotic Process
Development Of Secondary Sexual Characteristics
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Acrosome Reaction
Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
Angiogenesis Involved In Wound Healing
Positive Regulation Of Circulating Fibrinogen Levels
Macrophage Migration
Mitotic Cell Cycle
Regulation Of Cell Growth
Regulation Of DNA-templated Transcription
Protein Phosphorylation
Apoptotic Process
Regulation Of Apoptotic Process
Regulation Of RNA Splicing
Regulation Of Centrosome Cycle
Regulation Of MRNA Processing
Regulation Of Cell Cycle
Pathways
Pre-NOTCH Processing in Golgi
Keratan sulfate biosynthesis
Interaction With Cumulus Cells And The Zona Pellucida
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective B4GALT1 causes CDG-2d
Lactose synthesis
Neutrophil degranulation
N-Glycan antennae elongation
Recruitment of mitotic centrosome proteins and complexes
Drugs
N-Acetylglucosamine
6-Aminohexyl-uridine-C1,5'-diphosphate
4)-N-acetyl-beta-D-glucosamine
Galactose-uridine-5'-diphosphate
Uridine monophosphate
2-(N-morpholino)ethanesulfonic acid
Diseases
Congenital disorders of glycosylation (CDG) type II
GWAS
Aspartate aminotransferase levels (
33547301
33339817
29403010
)
Blood protein levels (
30072576
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
IgG fucosylation phenotypes (multivariate analysis) (
28878392
)
IgG galactosylation phenotypes (multivariate analysis) (
28878392
)
IgG glycosylation (
23382691
)
IgG N-glycosylation phenotypes (multivariate analysis) (
28878392
32128391
)
Influenza A (H1N1) infection (
26379185
)
Iron status biomarkers (ferritin levels) (
33536631
)
Mild influenza (H1N1) infection (
26379185
)
N-glycan levels (
31163085
)
Red blood cell count (
32888494
)
Serum uric acid levels (
30993211
)
Severe influenza A (H1N1) infection (
26379185
)
Urate levels (
31578528
31985003
23263486
)
Body mass index (
26426971
)
Interacting Genes
9 interacting genes:
CDK11A
EGFR
LALBA
OR10G4
SNCA
TFRC
TUBA1A
TUBA4A
TUBB
7 interacting genes:
B4GALT1
CCNL1
GADD45A
GADD45G
PIN1
SKIC2
SPDEF
Entrez ID
2683
728642
HPRD ID
00659
Ensembl ID
ENSG00000086062
ENSG00000008128
Uniprot IDs
B7ZAH9
P15291
Q86XA6
W6MEN3
Q4VBY6
Q5QPR3
Q9UQ88
PDB IDs
2AE7
2AEC
2AES
2AGD
2AH9
2FY7
2FYA
2FYB
3EE5
4EE3
4EE4
4EE5
4EEA
4EEG
4EEM
4EEO
4L41
6FWT
6FWU
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle
Structural Constituent Of Cytoskeleton
Extracellular Region
Regulation Of Cellular Component Organization
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Clathrin-coated Endocytic Vesicle Membrane
Positive Regulation Of Protein Localization To Cell Periphery
Response To Lipid
Protein-containing Complex
Virus Receptor Activity
Negative Regulation Of Apoptotic Process
Shc-EGFR Complex
Extracellular Space
Multivesicular Body, Internal Vesicle Lumen
Lactose Biosynthetic Process
CCR7 Chemokine Receptor Binding
CCL19-activated CCR7 Signaling Pathway
Positive Regulation Of Dendritic Cell Dendrite Assembly
Response To Desipramine
Response To Iron Ion
Adult Locomotory Behavior
Negative Regulation Of Norepinephrine Uptake
Response To Copper Ion
Response To Metal Ion
Regulation Of Synapse Organization
Phospholipase D Inhibitor Activity
Regulation Of Norepinephrine Uptake
Positive Regulation Of SNARE Complex Assembly
Receptor Internalization
Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Hsp70 Protein Binding
Transferrin Receptor Activity
Protein-containing Complex Binding
Microtubule
Microtubule Cytoskeleton
GTP Binding
Cytoplasmic Ribonucleoprotein Granule
Apoptotic Process
Negative Regulation Of Programmed Cell Death
Nucleotide Binding
Enzyme Binding
Regulation Of Cell Growth
Positive Regulation Of Protein Kinase C Signaling
Epidermal Growth Factor Receptor Activity
Cell Death
Programmed Cell Death
Lactose Synthase Activity
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of P38MAPK Cascade
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of P38MAPK Cascade
Regulation Of Cell Cycle
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Positive Regulation Of Circulating Fibrinogen Levels
Cis-trans Isomerase Activity
Nuclear Speck
Positive Regulation Of JNK Cascade
Epithelial Cell Development
Lactose Biosynthetic Process
UDP-galactosyltransferase Activity
Lactose Synthase Activity
Protein Peptidyl-prolyl Isomerization
Phosphothreonine Residue Binding
Ski Complex
Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay
Lung Goblet Cell Differentiation
Regulation Of JNK Cascade
N-acetyllactosamine Synthase Activity
Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity
Regulation Of MAPK Cascade
Glandular Epithelial Cell Development
Development Of Secondary Sexual Characteristics
Phosphoserine Residue Binding
Negative Regulation Of Peptidyl-serine Phosphorylation
Galactosyltransferase Activity
3'-5' RNA Helicase Activity
Golgi Trans Cisterna
Disaccharide Metabolic Process
Galactose Metabolic Process
Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
Penetration Of Zona Pellucida
Mitogen-activated Protein Kinase Kinase Binding
Intestinal Epithelial Cell Development
GTPase Activating Protein Binding
Ubiquitin Ligase Activator Activity
Epithelial Cell Fate Commitment
Positive Regulation Of Cell Fate Commitment
Regulation Of Acrosome Reaction
Negative Regulation Of Cell Fate Commitment
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