B4GALT1 and TFRC

Number of citations of the paper that reports this interaction (PMID 7744867)
23

Data Source:
BioGRID (pull down)

		B4GALT1	TFRC
Gene Name		UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	transferrin receptor
Image
Gene Ontology Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Desmosome Glycocalyx Filopodium Brush Border Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Membrane-bounded Vesicle Vesicle Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Cytoskeletal Protein Binding Galactosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity Protein Homodimerization Activity Alpha-tubulin Binding Beta-tubulin Binding	Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Epithelial Cell Development Acute Inflammatory Response Carbohydrate Metabolic Process Lactose Biosynthetic Process Galactose Metabolic Process Protein N-linked Glycosylation Cell Adhesion Notch Signaling Pathway Single Fertilization Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Negative Regulation Of Cell Proliferation Oligosaccharide Biosynthetic Process Pathogenesis Keratan Sulfate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Mammary Gland Development Multicellular Organism Reproduction Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Development Of Secondary Sexual Characteristics Branching Morphogenesis Of An Epithelial Tube Leukocyte Migration Regulation Of Cellular Component Movement Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution	Regulation Of Cell Growth Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Viral Process Osteoclast Differentiation Transferrin Transport Cellular Response To Drug Regulation Of Cell Proliferation Positive Regulation Of Bone Resorption Transmembrane Transport Iron Ion Import
Pathways		Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) Fertilization N-Glycan antennae elongation Defective CHST14 causes EDS, musculocontractural type N-glycan antennae elongation in the medial/trans-Golgi Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Keratan sulfate biosynthesis Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Signaling by NOTCH Defective EXT2 causes exostoses 2 Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Pre-NOTCH Expression and Processing Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Pre-NOTCH Processing in Golgi Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Interaction With The Zona Pellucida	Iron uptake and transport Golgi Associated Vesicle Biogenesis Transferrin endocytosis and recycling trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs		N-Acetyl-D-glucosamine 6-Aminohexyl-Uridine-C1,5\'-Diphosphate Di(N-Acetyl-D-Glucosamine) Uridine Diphosphate Galactose Uridine-5\'-Monophosphate 2-(N-Morpholino)-Ethanesulfonic Acid
Diseases
GWAS		IgG glycosylation ( 23382691) Urate levels ( 23263486)	Mean corpuscular hemoglobin ( 20139978 19862010) Mean corpuscular volume ( 20139978 19862010) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517)
Protein-Protein Interactions		6 interactors: CDK11A LALBA TFRC TUBA1A TUBA4A TUBB	11 interactors: ACAP1 B4GALT1 CD247 CD4 GABARAP HFE RAB5B RAB8A RANBP9 SGTA TF
Entrez ID		2683	7037
HPRD ID		00659	01812
Ensembl ID		ENSG00000086062	ENSG00000072274
Uniprot IDs		P15291	A8K6Q8 P02786
PDB IDs		2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N
Enriched GO Terms of Interacting Partners?		Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Interleukin-4 Cell Cycle Process Cellular Protein Complex Assembly Response To Interleukin-4 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Microtubule Cytoskeleton Organization Cell Cycle Cellular Macromolecular Complex Assembly Lactose Biosynthetic Process Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Disaccharide Metabolic Process Protein Complex Assembly Cytoskeleton Organization Protein Folding Iron Ion Import Organelle Organization Positive Regulation Of Bone Resorption Oligosaccharide Biosynthetic Process Cell Division Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Positive Regulation Of Tissue Remodeling Transferrin Transport Leukocyte Mediated Cytotoxicity Cellular Component Assembly Cellular Response To Cytokine Stimulus Regulation Of Bone Resorption Establishment Of Localization In Cell Regulation Of Bone Remodeling Osteoclast Differentiation Response To Cytokine Oligosaccharide Metabolic Process Cellular Response To Drug Cellular Localization Regulation Of Tissue Remodeling	Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Defense Response To Virus By Virus Cellular Protein Localization Cellular Localization Transport Rab Protein Signal Transduction Cellular Response To Iron Ion Starvation Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation T Cell Costimulation Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Iron Ion Transport Regulation Of Defense Response To Virus Cellular Iron Ion Homeostasis T Cell Receptor Signaling Pathway Establishment Of Localization In Cell Iron Ion Homeostasis Lactose Biosynthetic Process Golgi Vesicle Fusion To Target Membrane Membrane Fusion Viral Process Immune System Process Response To Stimulus Antigen Receptor-mediated Signaling Pathway Cellular Response To Starvation Transition Metal Ion Homeostasis Response To Stress Regulation Of Exocytosis Disaccharide Metabolic Process Positive Regulation Of Immune Response Cellular Response To Nutrient Levels Response To Starvation Iron Ion Import Into Cell Vesicle-mediated Transport Penetration Of Zona Pellucida Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Plasma Membrane To Endosome Transport Intracellular Transport Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of T Cell Activation Cellular Response To Extracellular Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Ras Protein Signal Transduction Multicellular Organismal Homeostasis Regulation Of Acrosome Reaction Positive Regulation Of Cell-cell Adhesion Cell Communication
Tagcloud ?		acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman top2a tubb3 tyms vegfr2
Tagcloud (Difference) ?		acetylglucosaminyltransferase amidase antennae asparagine atp6v0a2 cdg cdgs cog7 documents fucose fucosylation galactosyltransferase glucosaminyl glycan glycans isofocusing mannosyl mgat2 n4 permethylated pngase sialidase slc35c1 transporting triantennary underglycosylation undersialylation unsolved v0	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman top2a tubb3 tyms vegfr2
Tagcloud (Intersection) ?