GSK3B and MAP3K1

Number of citations of the paper that reports this interaction (PubMedID 12584189)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		GSK3B	MAP3K1
Description		glycogen synthase kinase 3 beta	mitogen-activated protein kinase kinase kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Plasma Membrane Membrane Axon Dendrite Beta-catenin Destruction Complex Presynapse Postsynapse Glutamatergic Synapse Wnt Signalosome	Cytoplasm Cytosol Tight Junction
	Molecular Function	Nucleotide Binding Protease Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Beta-catenin Binding Kinase Activity Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding Dynactin Binding Tau Protein Binding Tau-protein Kinase Activity NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Scaffold Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Positive Regulation Of Cell-matrix Adhesion Cytoplasmic Translational Initiation Heart Valve Development Glycogen Metabolic Process Protein Phosphorylation ER Overload Response Mitochondrion Organization Regulation Of Mitotic Cell Cycle Nervous System Development Circadian Rhythm Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Viral Protein Processing Hippocampus Development Establishment Of Cell Polarity Maintenance Of Cell Polarity Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Axon Extension SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule-based Process Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Cellular Response To Interleukin-3 TORC2 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cilium Assembly Positive Regulation Of Translation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Rhythmic Process Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Excitatory Postsynaptic Potential Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Superior Temporal Gyrus Development Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Presynaptic Modulation Of Chemical Synaptic Transmission Neuron Projection Organization Membraneless Organelle Assembly Regulation Of Microtubule Anchoring At Centrosome Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Cellular Response To Heat Negative Regulation Of Protein Localization To Nucleus Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Cilium Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Cellular Response To Amyloid-beta Positive Regulation Of Protein Localization To Centrosome Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Mesenchymal Stem Cell Differentiation	MAPK Cascade Protein Phosphorylation Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Mechanical Stimulus
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade AKT phosphorylates targets in the cytosol Regulation of HSF1-mediated heat shock response CRMPs in Sema3A signaling Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane B-WICH complex positively regulates rRNA expression Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Constitutive Signaling by AKT1 E17K in Cancer Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D Regulation of RUNX2 expression and activity Maturation of nucleoprotein Maturation of nucleoprotein GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Transcriptional and post-translational regulation of MITF-M expression and activity GSK3B-mediated proteasomal degradation of PD-L1(CD274)	MyD88:MAL(TIRAP) cascade initiated on plasma membrane FCERI mediated MAPK activation FCERI mediated MAPK activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs		Lithium cation 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione SB-409513 AR-AO-14418 Staurosporine Indirubin-3'-monoxime 6-bromoindirubin-3'-oxime Alsterpaullone Phosphoaminophosphonic Acid-Adenylate Ester 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE Fostamatinib Tideglusib Lithium citrate Lithium succinate Lithium carbonate	AZD-8330 Binimetinib Fostamatinib
Diseases
GWAS		HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 19330030 20453838 29059683 23535729 17529967 31757997) Breast cancer (early onset) ( 24493630) Brown vs. black hair color ( 30531825) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 25631608) Fasting glucose in pregnancy (gestational week 14-16) ( 30324795) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Initial pursuit acceleration ( 29064472) Lung function (FEV1) ( 30061609) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Sexual dimorphism in anthropometric traits ( 23754948) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32902719 28334899) Triglycerides ( 20686565 24097068) Type 2 diabetes ( 23209189) Urate levels (BMI interaction) ( 25811787) Waist circumference ( 23966867) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		245 interacting genes: ACLY ACSBG1 ACTL6B ADAP1 ADIRF AKAP11 AKT1 AKT2 AKT3 APC APP AR ARRB1 ASRGL1 ATP5IF1 ATXN3 AURKA AXIN1 AXIN2 BAG6 BCCIP BCL2A1 BCL2L1 BCL2L12 BCL3 BEX1 BHLHE41 BICD1 BICD2 BRIX1 BTRC BZW2 C10orf90 C11orf98 CABYR CAMSAP3 CCND1 CCNE1 CDH1 CDK5 CDX2 CEBPA CEBPD CEBPZ CENPB CHD3 CIITA CLEC3B CMTM2 CREB1 CREB3L3 CREM CSAD CSNK2B CST6 CTNNB1 CTNND1 DBI DCP1B DCTN1 DCTN2 DCTN3 DDIT4 DEAF1 DEFA1 DELEC1 DHX34 DISC1 DNAJC13 DNM1L DNMT1 DNMT3L DPYSL2 DRC9 DUSP9 DYNC1I1 E2F1 EEF1G EFTUD2 EIF2B5 EIF4EBP1 ENTPD6 ERG28 EYA1 FAM193B FAM83D FBN3 FBXL21P FBXO7 FBXW11 FEN1 FIBP FKBP14 FOXO1 FRAT1 FRAT2 FZD5 GBP2 GFI1 GIPC1 GJB5 GOLM2 GPR39 GRIA2 GYS1 HDAC4 HNRNPD HNRNPM HSP90AB1 HSPA4 IGHM IGSF21 IKBKG ILK IRF1 JUN KDM1A KHSRP KIAA1191 KIF5B KLF2 KLF5 LMO4 LPCAT1 LRP6 LUC7L2 LYAR MAP1B MAP3K1 MAP3K4 MAP4 MAPK1 MAPT MARK2 MASP1 MCL1 MDM2 MED24 MEG3 MICAL1 MID1IP1 MITF MPP1 MTF2 MTOR MUC1 MYC MYL6 MYOCD MYOZ1 NAT9 NBR1 NCOA3 NDRG1 NFE2L1 NFE2L2 NFE2L3 NFKB1 NIN NOTCH1 NOTCH2 NRBP1 NSFL1C OGA OGT PDE4D PDPK1 PFKFB4 PHLPP1 PIAS1 PICK1 PIM2 PMAIP1 PPARGC1A PPP1R2 PRKACA PRKCA PRKCB PRKCZ PRKDC PRKRIP1 PSEN1 PSMD8 PTK2 PTN PTPA PTPN1 PXN QARS1 RAI1 RBPJ RCAN1 RELB RICTOR RPL36AL RPLP1 RPS15 RPS2 RPS6KA1 RSU1 RXRA SAP30BP SGK1 SGK3 SLA SMAD3 SMG7 SNAI1 SNCAIP SOX10 SPI1 SPTBN4 SREBF1 STAT2 SYNE4 TAFAZZIN TCAP TEKT5 TLE1 TMEM132A TMEM44 TONSL TP53 TPPP TRIM72 TSC2 TUBA1A UBE2D1 UBR1 UBR5 UBXN6 UFM1 UPF3A VIM VPS51 XIAP XPNPEP1 YBX1 YBX3 YWHAZ ZFPM1 ZHX1 ZNF135 ZNF227 ZNF746	94 interacting genes: ACTN1 APEX2 APPL1 ARHGAP4 ASCC2 ATXN3 BAALC BAP1 BRCA1 CARD14 CCDC69 CD74 CEP85 CHRM5 CHUK COPS6 CRELD1 CRTC1 CUEDC1 DCUN1D1 DCUN1D2 DENND6B DNAJB2 DNAJB6 DTX1 EPHA1 EPN1 FAF2 FAM184A FKBP6 GGA2 GRIPAP1 GSK3B HBS1L HGS HIP1 IKBKB ILRUN IMPACT KRT36 MAP2K4 MAP2K7 MAPK1 MAPK9 MBP MINDY3 NEK10 NFKBIA NOTCH1 NPLOC4 NR4A1 ODF2 PAK1 PLEKHB2 PSMD4 RAB3IL1 RABEP2 RAD18 RAD23A RAD51AP1 RAF1 RBCK1 RNF114 RNF126 RNF141 SPART STAM STAM2 TAB1 TNIP1 TOM1L2 TP53 TRAF2 UBAC1 UBAP1 UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G1 UBE2I UBE2K UBE2L6 UBE2V1 UBE2W UBQLN1 UBXN7 UCHL5 UFD1 USP28 ZFAND3 ZFAND5
Entrez ID		2932	4214
HPRD ID		05418	19599
Ensembl ID		ENSG00000082701	ENSG00000095015
Uniprot IDs		A0A3B3ITW1 P49841 Q6FI27	Q13233
PDB IDs		1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3MV5 3OW4 3PUP 3Q3B 3QKK 3QKL 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4IQ6 4J1R 4J71 4NM0 4NM3 4NM5 4NM7 4PTC 4PTE 4PTG 5F94 5F95 5HLN 5HLP 5K5N 5KPK 5KPL 5KPM 5OY4 5T31 6B8J 6BUU 6GJO 6GN1 6H0U 6HK3 6HK4 6HK7 6NPZ 6TCU 6V6L 6Y9R 6Y9S 7B6F 7OY5 7SXH 7SXJ 7U2Z 7U31 7U33 7U36 7Z1F 7Z1G 8AUZ 8AV1 8DJC 8DJD 8DJE 8FF8 8QJI 8XN6	6WHB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cytosol Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cell Communication Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Developmental Process Signal Transduction	Ubiquitin Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytosol Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Protein Modification By Small Protein Conjugation Protein Modification Process Catabolic Process Protein Polyubiquitination Proteolysis Positive Regulation Of Protein Modification Process Protein Ubiquitination Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Modification Process Cytoplasm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activity Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Metabolic Process Transferase Activity Regulation Of Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Signal Transduction VCP-NPL4-UFD1 AAA ATPase Complex Protein K48-linked Ubiquitination Nucleoplasm ESCRT-0 Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Intracellular Protein Transport Protein Transport Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Identical Protein Binding Regulation Of Intracellular Signal Transduction Intracellular Protein Localization Non-canonical NF-kappaB Signal Transduction DNA Repair Regulation Of Immune Response Regulation Of Post-translational Protein Modification
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