ANKRD35 and RBCK1

Number of citations of the paper that reports this interaction (PubMedID 36732658)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ANKRD35	RBCK1
Description		ankyrin repeat domain 35	RANBP2-type and C3HC4-type zinc finger containing 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytosol LUBAC Complex
	Molecular Function	Actin Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Sequestering Activity Ubiquitin Ligase Activator Activity
	Biological Process		Protein Polyubiquitination Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Night sleep phenotypes ( 27126917)
Interacting Genes		7 interacting genes: CACNA1C RBCK1 SHANK3 SRPK2 TSC1 TSC2 VIM	71 interacting genes: ANKRD35 ANTXR1 APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MAP3K1 MAPKBP1 MKRN2 MTSS1 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RELA RIPPLY3 RNF181 RNF26 RNF31 SHARPIN SMURF1 SOCS6 SYCE1 TNF TNFAIP3 TP53 TRAF1 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414
Entrez ID		148741	10616
HPRD ID		08050	16643
Ensembl ID		ENSG00000198483	ENSG00000125826
Uniprot IDs		B4DFX6 F6XZD3 Q8N283	A0A8V8TMZ2 A6PVJ6 Q9BYM8
PDB IDs			2CRC 2LGY 4DBG 7V8E 7YUI 7YUJ 8BVL 8EAZ 8K6Q 9EGV 9EGW
Enriched GO Terms of Interacting Partners?		TSC1-TSC2 Complex Postsynaptic Density Hsp90 Protein Binding Negative Regulation Of Macroautophagy Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Actin Filament-based Process Intracellular Signal Transduction Memory T Cell Differentiation Positive Regulation Of TOR Signaling Negative Regulation Of Autophagy Negative Regulation Of TORC1 Signaling Tube Closure Positive Regulation Of TORC1 Signaling Regulation Of Cell Size Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling TORC1 Signaling Associative Learning Neural Tube Closure Scaffold Protein Binding Guanylate Kinase-associated Protein Clustering Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Tube Formation Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Signal Transduction Nuclear Speck Organization Regulation Of TOR Signaling Adult Behavior LUBAC Complex Synaptic Receptor Adaptor Activity Membrane Depolarization During AV Node Cell Action Potential Immune System Development ATPase Inhibitor Activity Learning Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Signal Transduction Cellular Response To Starvation Keratin Filament Binding Regulation Of Macroautophagy Protein Linear Polyubiquitination Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Heart Development Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Transferase Activity Catabolic Process Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Cysteine-type Peptidase Activity Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Defense Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of DNA-templated Transcription Free Ubiquitin Chain Polymerization Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process
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