TRPM2 and ITPR3

Number of citations of the paper that reports this interaction (PMID 11290752)
57

Data Source:
HPRD (in vitro)

		TRPM2	ITPR3
Gene Name		transient receptor potential cation channel, subfamily M, member 2	inositol 1,4,5-trisphosphate receptor, type 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell
	Molecular Function	Calcium Channel Activity Sodium Channel Activity Manganese Ion Transmembrane Transporter Activity ADP-ribose Diphosphatase Activity	Inositol Hexakisphosphate Binding Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Calcium Ion Transport Metabolic Process Response To Hydroperoxide Ion Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport	Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Memory Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Protein Homooligomerization Protein Heterooligomerization Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport
Pathways		Ion channel transport TRP channels Stimuli-sensing channels	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS			Educational attainment ( 23722424) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539)
Protein-Protein Interactions		2 interactors: ITPR3 TRPC6	13 interactors: AKT1 ANK1 CABP1 ITPR1 SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2
Entrez ID		7226	3710
HPRD ID		04777	00926
Ensembl ID		ENSG00000142185	ENSG00000096433
Uniprot IDs		E9PGK7 O94759	A6H8K3 Q14573 Q59ES2
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Platelet Activation Calcium Ion Transmembrane Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Calcium Ion Transport Cellular Metal Ion Homeostasis Blood Coagulation Hemostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To Inorganic Substance Sensory Perception Of Sweet Taste Cellular Chemical Homeostasis Sensory Perception Of Umami Taste Ion Homeostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Cellular Homeostasis Response To Wounding Metal Ion Transport Chemical Homeostasis Inositol Phosphate-mediated Signaling Cation Transmembrane Transport Cation Transport Sensory Perception Of Bitter Taste Ion Transmembrane Transport Homeostatic Process Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Long-term Synaptic Potentiation Activation Of Phospholipase C Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Cellular Response To Hydrogen Peroxide Sensory Perception Of Taste Transmembrane Transport Ion Transport Positive Regulation Of Phospholipase Activity Positive Regulation Of Ion Transmembrane Transport Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Calcium Ion Transport Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway	Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Cation Transport Metal Ion Transport Axonogenesis Cation Transmembrane Transport Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Ion Transport Cell Projection Organization Cell Morphogenesis Involved In Differentiation Platelet Activation Ion Transmembrane Transport Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Nervous System Development Generation Of Neurons Regulation Of Body Fluid Levels Neurogenesis Cell Morphogenesis Transmembrane Transport Neuron Differentiation Transport Cell Development Response To External Stimulus Locomotion Blood Coagulation Hemostasis Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Movement Of Cell Or Subcellular Component Multicellular Organismal Development Wound Healing Regulation Of Ion Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Manganese Ion Transport Cell Activation Response To Wounding Developmental Process System Development Chemical Homeostasis Response To Oxidative Stress Regulation Of Intracellular Transport Cell Differentiation
Tagcloud ?		10f acceleration bax bc12 became benzo bp1 chemically chemoprevention chorionic cip1 commercially elevation gonadotropin grew hbec hcg hour hours ice immortalized lies mcf moderately p21waf1 pyrene t24 urothelial utilize	anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually
Tagcloud (Difference) ?		10f acceleration bax bc12 became benzo bp1 chemically chemoprevention chorionic cip1 commercially elevation gonadotropin grew hbec hcg hour hours ice immortalized lies mcf moderately p21waf1 pyrene t24 urothelial utilize	anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually
Tagcloud (Intersection) ?