TRPM2 and TRPC6

Number of citations of the paper that reports this interaction (PMID 12032305)
131

Data Source:
HPRD (in vitro, in vivo)

		TRPM2	TRPC6
Gene Name		transient receptor potential cation channel, subfamily M, member 2	transient receptor potential cation channel, subfamily C, member 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Membrane Slit Diaphragm
	Molecular Function	Calcium Channel Activity Sodium Channel Activity Manganese Ion Transmembrane Transporter Activity ADP-ribose Diphosphatase Activity	Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Calcium Ion Transport Metabolic Process Response To Hydroperoxide Ion Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport	Cation Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Aging Blood Coagulation Platelet Activation Positive Regulation Of Ion Transmembrane Transporter Activity Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways		Ion channel transport TRP channels Stimuli-sensing channels	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ITPR3 TRPC6	9 interactors: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		7226	7225
HPRD ID		04777	04710
Ensembl ID		ENSG00000142185	ENSG00000137672
Uniprot IDs		E9PGK7 O94759	Q9Y210
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Platelet Activation Calcium Ion Transmembrane Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Calcium Ion Transport Cellular Metal Ion Homeostasis Blood Coagulation Hemostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To Inorganic Substance Sensory Perception Of Sweet Taste Cellular Chemical Homeostasis Sensory Perception Of Umami Taste Ion Homeostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Cellular Homeostasis Response To Wounding Metal Ion Transport Chemical Homeostasis Inositol Phosphate-mediated Signaling Cation Transmembrane Transport Cation Transport Sensory Perception Of Bitter Taste Ion Transmembrane Transport Homeostatic Process Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Long-term Synaptic Potentiation Activation Of Phospholipase C Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Cellular Response To Hydrogen Peroxide Sensory Perception Of Taste Transmembrane Transport Ion Transport Positive Regulation Of Phospholipase Activity Positive Regulation Of Ion Transmembrane Transport Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Calcium Ion Transport Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway	Calcium Ion Transport Blood Coagulation Hemostasis Platelet Activation Calcium Ion Transmembrane Transport Regulation Of Body Fluid Levels Wound Healing Response To Wounding Metal Ion Transport Response To Stress Cation Transport Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ion Transport Manganese Ion Transmembrane Transport Cation Transmembrane Transport Axon Guidance Manganese Ion Transport Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Axonogenesis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ion Transmembrane Transport Response To Hydroperoxide Chemotaxis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Morphogenesis Involved In Differentiation Phagocytosis Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Morphogenesis Transmembrane Transport Cell Part Morphogenesis Transport Response To External Stimulus Neuron Development
Tagcloud ?		10f acceleration bax bc12 became benzo bp1 chemically chemoprevention chorionic cip1 commercially elevation gonadotropin grew hbec hcg hour hours ice immortalized lies mcf moderately p21waf1 pyrene t24 urothelial utilize	blocker ca casr channels depending elicited eliminated exchanger expressions ip3 lymphocytes nicl2 nps plc rise sensing sepsis septic skf96365 sr stores tg thapsigargin transient trpc3 u73122 verapamil
Tagcloud (Difference) ?		10f acceleration bax bc12 became benzo bp1 chemically chemoprevention chorionic cip1 commercially elevation gonadotropin grew hbec hcg hour hours ice immortalized lies mcf moderately p21waf1 pyrene t24 urothelial utilize	blocker ca casr channels depending elicited eliminated exchanger expressions ip3 lymphocytes nicl2 nps plc rise sensing sepsis septic skf96365 sr stores tg thapsigargin transient trpc3 u73122 verapamil
Tagcloud (Intersection) ?